Variant Gene Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE Breast cancer susceptibility associated with rs1219648 (fibroblast growth factor receptor 2) and postmenopausal hormone therapy use in a population-based United States study. 23435034 2013
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE Only 5 out of 9 GWAS breast cancer loci were found to be significantly associated with breast cancer in Tunisians: The rs1219648 (G vs. A allele: OR = 1.36, P = 1 × 10(-3)) and rs2981582 (A vs. G allele: OR = 1.55, P = 3 × 10(-6)) of FGFR2 gene; the rs8051542 of the TNRC9 gene (T vs. C allele: OR = 1.40, P = 4 × 10(-4)); the rs889312 of the MAP3K1 gene (C vs. A allele: OR = 1.33, P = 3 × 10(-3)) and the rs13281615 located on 8q24 (G vs. A allele: OR = 1.21, P = 0.03). 22910930 2013
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE Four SNPs mapped to 10q26.13/FGFR2 were associated with increased breast cancer risk via an additive model with per-allelic risks (95 % CI) of 1.26 (1.12-1.43) at rs1219648, 1.22 (1.07-1.38) at rs2981582, 1.21 (1.07-1.36) at rs2981579, and 1.18 (1.04-1.35) at rs11200014. 22965832 2013
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE To investigate this inconsistency, we performed a meta-analysis of 37 studies involving a total of 288,142 subjects for rs2981582, rs1219648, and rs2420946 polymorphism of the FGFR2 gene to evaluate the effect of FGFR2 on genetic susceptibility for BC. 23184080 2013
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE In the haplotype analysis, the FGFR2 rs2981582 T / rs2420946 T / rs1219648 G haplotype (ht2) was associated with a significantly increased BC risk compared with the rs2981582 C / rs2420946 C / rs1219648 A haplotype in familial BC and in non-familial early-onset BC (OR = 1.32, 95 % CI 1.06-1.65, P = 0.012; OR = 1.46, 95 % CI 1.11-1.91, P = 0.004, respectively). 23225170 2013
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE To examine whether these variants contribute to risk of radiation-associated breast cancer in HL, we analyzed 2 independent case-control series, from the United Kingdom and The Netherlands, totaling 693 HL patients, 232 with breast cancer and 461 without. rs1219648, which annotates the FGFR2 gene, was associated with risk in both series (combined per-allele odds ratio = 1.59, 95% confidence interval: 1.26-2.02; P = .000111). 22144180 2012
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE Three commonly studied FGFR2 polymorphisms including rs1219648 (A > G), rs2420946 (C > T), and rs2981582 (C > T) were selected to explore their association with risk of development of breast cancer by meta-analysis of published case-control studies. 20300826 2011
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE In conclusion, this meta-analysis suggests that rs2981582, rs1219648, and rs2420946 polymorphisms in FGFR2 are associated with elevated BC risk. 20364400 2011
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE The FGFR2-breast cancer association was modified by smoking status, with increased risk for former and current smokers compared to never smokers; former/current smokers carrying two copies of the rs1219648 minor allele were at highest risk with a crude OR (95% confidence interval) of 2.11 (1.52-2.92) compared to never smokers with no rs1219648 variant alleles. 20853316 2011
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE Risk of aggressive breast cancer in women of Han nationality carrying TGFB1 rs1982073 C allele and FGFR2 rs1219648 G allele in North China. 20640597 2011
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE FGFR2 haplotypes based upon rs11200014, rs2981579, rs1219648 and rs2420946 were associated with increased risk of breast cancer, including the GTGT haplotype in AAs [OR = 1.27, 95% confidence interval (CI) 1.04-1.56] and younger women of either race [OR = 1.35, 95% CI 1.02-1.78) and the ATGT haplotype in Whites (OR = 1.30, 95% CI 1.15-1.46). 20554749 2010
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE Two single-nucleotide polymorphisms, rs13387042 (2q35) and rs1219648 (FGFR2 gene), were found to be associated with breast cancer risk. 19789366 2010
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE An interaction was observed between combined hormone replacement therapy use and FGFR2 rs1219648 genotypes on breast cancer risk in EA women (P = 0.010). 19028704 2009
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE We genotyped 13 single nucleotide polymorphisms (SNPs) densely covering a 27 kb region within intron 2 of FGFR2 including two SNPs (rs2981582 and rs1219648) significantly associated with breast cancer and a total 40 tagSNPs across 150 kb of the FGFR2 gene. 18285324 2008
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE Genetic variation in FGFR2, identified by rs1219648, may account for a substantial fraction of breast cancer in Arab (12%), Ashkenazi (15%), and Sephardi Jewish (22%) populations. 18483326 2008