Multivariate model analysis, including T2D status, age, and body mass index (BMI), displayed significant covariance in PPARGC-1α rs8192678; SIRT1 rs7896005; TCF7L2 rs7903146 and rs122243326; UCP3 rs3781907; and HHEX rs1111875 with a P < 0.05.
All polymorphisms were in Hardy-Weinberg equilibrium, and the association by genotype with T2D-related traits displayed nominal significance for rs8192678 with glucose (<i>p</i> = 0.023) and triglycerides (<i>p</i> = 0.013); rs2010963 with diastolic blood pressure (DBP) (<i>p</i> = 0.012) and cholesterol (<i>p</i> = 0.013); rs7896005 with DBP (<i>p</i> = 0.012) and insulin (<i>p</i> = 0.011); and rs659366 with cholesterol (<i>p</i> = 0.034), glucose (<i>p</i> = 0.031) and triglycerides (<i>p</i> = 0.028); and the association of rs2010963 with HDL-C (<i>p</i> = 0.0007) was significant.
Two tag SNPs, rs10509291 and rs7896005, were nominally associated with type 2 diabetes (P=0.01, OR=1.25 95%CI 1.05-1.48, and P=0.02, OR=1.17 95%CI 1.02-1.34, respectively; additive P values adjusted for age, sex, birth year, and family membership), but not BMI (adjusted P values 0.52 and 0.45, respectively).