ALK, ALK receptor tyrosine kinase, 238

N. diseases: 519; N. variants: 41
Disease: Malignant Neoplasms ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057519859
rs1057519859
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0006826
Disease:
Malignant Neoplasms 		0.010 GeneticVariation BEFREE However, L1198F paradoxically enhances binding to crizotinib, negating the effect of C1156Y and resensitizing resistant cancers to crizotinib. 26698910 2016