FRZB, frizzled related protein, 2487

N. diseases: 89; N. variants: 8
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7775
rs7775
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C3887876
Disease:
OSTEOARTHRITIS SUSCEPTIBILITY 1
0.800 GeneticVariation UNIPROT Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. 15210948 2004
dbSNP: rs7775
rs7775
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C3887876
Disease:
OSTEOARTHRITIS SUSCEPTIBILITY 1
C 0.800 SusceptibilityMutation CLINVAR
dbSNP: rs1561369
rs1561369
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0005890
Disease:
Body Height
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs288326
rs288326
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C2985280
Disease:
Blood Protein Measurement
A 0.700 GeneticVariation GWASCAT Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936. 31320639 2019
dbSNP: rs7566497
rs7566497
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0025265
Disease:
Memory, Short-Term
0.700 GeneticVariation GWASCAT Genome-Wide Association Study of Latent Cognitive Measures in Adolescence: Genetic Overlap With Intelligence and Education. 31598132 2019
dbSNP: rs288326
rs288326
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C2985280
Disease:
Blood Protein Measurement
A 0.700 GeneticVariation GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
dbSNP: rs6433994
rs6433994
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C2985280
Disease:
Blood Protein Measurement
T 0.700 GeneticVariation GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
dbSNP: rs288326
rs288326
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C3887876
Disease:
OSTEOARTHRITIS SUSCEPTIBILITY 1
A 0.700 SusceptibilityMutation CLINVAR
dbSNP: rs7775
rs7775
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0029408
Disease:
Degenerative polyarthritis
0.050 GeneticVariation BEFREE Findings of this collaborative analysis do not support the notion that FRZB rs7775 or rs288326 has any sizable genetic effect on OA phenotypes. 19479880 2009
dbSNP: rs7775
rs7775
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0029408
Disease:
Degenerative polyarthritis
0.050 GeneticVariation BEFREE While power was limited for most studies to date, a meta-analysis of all published studies regarding the FRZB Arg324Gly polymorphism was performed for hip- and knee-OA separately. 18406176 2008
dbSNP: rs7775
rs7775
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0029408
Disease:
Degenerative polyarthritis
0.050 GeneticVariation BEFREE No direct replication of previous OA association findings was obtained but the results suggest that the R324G SNP of the FRZB gene may have an effect in OA development in multiple joints, with a specific severe involvement of the hip in women. 17237116 2007
dbSNP: rs7775
rs7775
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0029408
Disease:
Degenerative polyarthritis
0.050 GeneticVariation BEFREE Our data confirm findings of another study, that a rare haplotype with both Arg200Trp and Arg324Gly FRZB variants contributes to the genetic susceptibility to hip OA among Caucasian women, and that these polymorphisms may contribute to increased serum levels of proteins as biomarkers of OA. 16572458 2006
dbSNP: rs7775
rs7775
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0029408
Disease:
Degenerative polyarthritis
0.050 GeneticVariation BEFREE Our results confirm that the R324G variant of the FRZB gene is involved in OA and indicate a role of this variant in several generalized OA phenotypes. 15818669 2005
dbSNP: rs7775
rs7775
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0009402
Disease:
Colorectal Carcinoma
0.030 GeneticVariation BEFREE We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (β-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n = 122) and controls (n = 110). 31485167 2019
dbSNP: rs288326
rs288326
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0029410
Disease:
Osteoarthritis of hip
0.030 GeneticVariation BEFREE The presence of the rs288326 SNP alters the relationship between proximal femur shape and incident radiographic hip OA. 22544526 2012
dbSNP: rs288326
rs288326
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0029408
Disease:
Degenerative polyarthritis
0.030 GeneticVariation BEFREE Findings of this collaborative analysis do not support the notion that FRZB rs7775 or rs288326 has any sizable genetic effect on OA phenotypes. 19479880 2009
dbSNP: rs288326
rs288326
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0029410
Disease:
Osteoarthritis of hip
0.030 GeneticVariation BEFREE Analyses for FRZB polymorphisms and haplotypes did not reveal any statistically significant signals, except for a borderline association of rs288326 with hip OA (P=0.019). 19479880 2009
dbSNP: rs7775
rs7775
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0009402
Disease:
Colorectal Carcinoma
0.030 GeneticVariation BEFREE The Wnt/APC/beta-catenin signaling pathway, which includes frizzled-related protein (FRZB), plays a critical role in the development of colorectal cancer, and recent evidence suggests that the functional polymorphism, FRZB Arg324Gly, may be associated with risk for this disease. 19067193 2009
dbSNP: rs7775
rs7775
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0029410
Disease:
Osteoarthritis of hip
0.030 GeneticVariation BEFREE For rs7775, the respective sample sizes were 4,352 and 10,843 for hip OA, 3,545 and 6,085 for knee OA, and 4,010 and 5,151 for hand OA, and for rs288326, they were 4,346 and 8,034 for hip OA, 3,595 and 6,106 for knee OA, and 3,982 and 5,152 for hand OA. 19479880 2009
dbSNP: rs7775
rs7775
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0009402
Disease:
Colorectal Carcinoma
0.030 GeneticVariation BEFREE Here, we investigated, for the first time, the role of Arg324Gly (970C>G) along with Arg200Trp (598C>T) on colorectal cancer (CRC) risk by analyzing 659 patients and 607 control individuals drawn from the German DACHS (Darmkrebs: Chancen der Verhütung durch Screening) study. 17420170 2007
dbSNP: rs288326
rs288326
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0029408
Disease:
Degenerative polyarthritis
0.030 GeneticVariation BEFREE Our data confirm findings of another study, that a rare haplotype with both Arg200Trp and Arg324Gly FRZB variants contributes to the genetic susceptibility to hip OA among Caucasian women, and that these polymorphisms may contribute to increased serum levels of proteins as biomarkers of OA. 16572458 2006
dbSNP: rs288326
rs288326
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0029410
Disease:
Osteoarthritis of hip
0.030 GeneticVariation BEFREE Our data confirm findings of another study, that a rare haplotype with both Arg200Trp and Arg324Gly FRZB variants contributes to the genetic susceptibility to hip OA among Caucasian women, and that these polymorphisms may contribute to increased serum levels of proteins as biomarkers of OA. 16572458 2006
dbSNP: rs7775
rs7775
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0029410
Disease:
Osteoarthritis of hip
0.030 GeneticVariation BEFREE Our data confirm findings of another study, that a rare haplotype with both Arg200Trp and Arg324Gly FRZB variants contributes to the genetic susceptibility to hip OA among Caucasian women, and that these polymorphisms may contribute to increased serum levels of proteins as biomarkers of OA. 16572458 2006
dbSNP: rs288326
rs288326
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0029408
Disease:
Degenerative polyarthritis
0.030 GeneticVariation BEFREE An association analysis of 2 variants (R200W and R324G) of FRZB was performed in a random sample of 1,369 subjects (ages 55-70 years) from a population-based cohort (the Rotterdam Study) scored for radiographic characteristics of OA in the hip, hand, spine, and knee and in a patient population of Caucasian probands (ages 40-70 years) and their siblings selected for the presence of primary symptomatic OA at multiple sites. 15818669 2005
dbSNP: rs7775
rs7775
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0029410
Disease:
Osteoarthritis of hip
0.030 GeneticVariation BEFREE In addition, a haplotype coding for substitutions of two highly conserved arginine residues (Arg200Trp and Arg324Gly) in FRZB was a strong risk factor for primary hip OA, with an odds ratio of 4.1 (P = 0.004). 15210948 2004