DisGeNET - a database of gene-disease associations

FUS, FUS RNA binding protein, 2521

N. diseases: 301; N. variants: 39

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs121909668

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

GeneticVariation

UNIPROT

Screening of SOD1, FUS and TARDBP genes in patients with amyotrophic lateral sclerosis in central-southern China.

27604643

2016

dbSNP:

rs121909669

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

GeneticVariation

UNIPROT

Screening of SOD1, FUS and TARDBP genes in patients with amyotrophic lateral sclerosis in central-southern China.

27604643

2016

dbSNP:

rs121909671

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

GeneticVariation

UNIPROT

Screening of SOD1, FUS and TARDBP genes in patients with amyotrophic lateral sclerosis in central-southern China.

27604643

2016

dbSNP:

rs267606831

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

GeneticVariation

UNIPROT

Screening of SOD1, FUS and TARDBP genes in patients with amyotrophic lateral sclerosis in central-southern China.

27604643

2016

dbSNP:

rs267606832

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

GeneticVariation

UNIPROT

Screening of SOD1, FUS and TARDBP genes in patients with amyotrophic lateral sclerosis in central-southern China.

27604643

2016

dbSNP:

rs121909668

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

CausalMutation

CLINVAR

Activity-dependent FUS dysregulation disrupts synaptic homeostasis.

25324524

2014

dbSNP:

rs121909668

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

CausalMutation

CLINVAR

Extensive molecular genetic survey of Taiwanese patients with amyotrophic lateral sclerosis.

24908169

2014

dbSNP:

rs121909668

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

CausalMutation

CLINVAR

ALS-associated FUS mutations result in compromised FUS alternative splicing and autoregulation.

24204307

2013

dbSNP:

rs121909668

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

CausalMutation

CLINVAR

Characterization of FUS mutations in amyotrophic lateral sclerosis using RNA-Seq.

23577159

2013

dbSNP:

rs121909668

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

CausalMutation

CLINVAR

FUS mutations in sporadic amyotrophic lateral sclerosis: clinical and genetic analysis.

22055719

2012

dbSNP:

rs267606832

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C3539195
Disease:

TREMOR, HEREDITARY ESSENTIAL, 4

0.800

GeneticVariation

UNIPROT

Exome sequencing identifies FUS mutations as a cause of essential tremor.

22863194

2012

dbSNP:

rs121909668

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

CausalMutation

CLINVAR

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.

20606625

2010

dbSNP:

rs121909668

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

CausalMutation

CLINVAR

SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations.

20577002

2010

dbSNP:

rs121909668

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

CausalMutation

CLINVAR

Frameshift and novel mutations in FUS in familial amyotrophic lateral sclerosis and ALS/dementia.

20668259

2010

dbSNP:

rs121909668

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

GeneticVariation

UNIPROT

Mutations of FUS gene in sporadic amyotrophic lateral sclerosis.

19861302

2010

dbSNP:

rs121909668

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

GeneticVariation

UNIPROT

Genetic contribution of FUS to frontotemporal lobar degeneration.

20124201

2010

dbSNP:

rs121909669

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

GeneticVariation

UNIPROT

Genetic contribution of FUS to frontotemporal lobar degeneration.

20124201

2010

dbSNP:

rs121909669

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

GeneticVariation

UNIPROT

Mutations of FUS gene in sporadic amyotrophic lateral sclerosis.

19861302

2010

dbSNP:

rs121909671

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

GeneticVariation

UNIPROT

Genetic contribution of FUS to frontotemporal lobar degeneration.

20124201

2010

dbSNP:

rs121909671

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

GeneticVariation

UNIPROT

Mutations of FUS gene in sporadic amyotrophic lateral sclerosis.

19861302

2010

dbSNP:

rs267606831

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

GeneticVariation

UNIPROT

Genetic contribution of FUS to frontotemporal lobar degeneration.

20124201

2010

dbSNP:

rs267606831

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

GeneticVariation

UNIPROT

Mutations of FUS gene in sporadic amyotrophic lateral sclerosis.

19861302

2010

dbSNP:

rs267606832

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

GeneticVariation

UNIPROT

Mutations of FUS gene in sporadic amyotrophic lateral sclerosis.

19861302

2010

dbSNP:

rs267606832

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

GeneticVariation

UNIPROT

Genetic contribution of FUS to frontotemporal lobar degeneration.

20124201

2010

dbSNP:

rs121909668

Entrez Id:	2521
Gene Symbol:	FUS

FUS

CUI:	C1842675
Disease:

AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)

0.800

CausalMutation

CLINVAR

Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.

19251627

2009