In search of genetic markers of myocardial infarction (MI) risk, which have prognostic significance for Russians, we performed a replication study of MI association with genetic variants of <i>PCSK9</i> (rs562556), <i>APOE</i> (epsilon polymorphism, rs7412 and rs429358), <i>LPL</i> (rs320), <i>MTHFR</i> (rs1801133), <i>eNOS</i> (rs2070744), and the 9p21 region (rs1333049) in 405 patients with MI and 198 controls.
With respect to PCSK9, E32K carriers showed higher LDL-cholesterol levels and younger age of onset for MI, whereas R93C carriers had lower LDL-cholesterol levels.
PCSK9 R46L carriers have lower levels of lipoprotein(a) and LDL cholesterol as well as reduced risk of aortic valve stenosis and myocardial infarction.