LMOD1, leiomodin 1, 25802

N. diseases: 49; N. variants: 10
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2820315
rs2820315
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C1956346
Disease:
Coronary Artery Disease 		T 0.710 GeneticVariation GWASCAT Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease. 29212778 2018
dbSNP: rs2820315
rs2820315
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C1956346
Disease:
Coronary Artery Disease 		0.710 GeneticVariation BEFREE We identified 25 new SNP-CAD associations (P < 5 × 10<sup>-8</sup>, in fixed-effects meta-analysis) from 15 genomic regions, including SNPs in or near genes involved in cellular adhesion, leukocyte migration and atherosclerosis (PECAM1, rs1867624), coagulation and inflammation (PROCR, rs867186 (p.Ser219Gly)) and vascular smooth muscle cell differentiation (LMOD1, rs2820315). 28530674 2017
dbSNP: rs2820313
rs2820313
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C0424574
Disease:
Duration of sleep 		G 0.700 GeneticVariation GWASCAT Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. 30846698 2019
dbSNP: rs17432675
rs17432675
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C0525045
Disease:
Mood Disorders 		C 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways. 29942085 2018
dbSNP: rs17432675
rs17432675
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C1269683
Disease:
Major Depressive Disorder 		C 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways. 29942085 2018
dbSNP: rs2820312
rs2820312
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C1305855
Disease:
Body mass index 		A 0.700 GeneticVariation GWASCAT Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 29273807 2018
dbSNP: rs2820315
rs2820315
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C1305855
Disease:
Body mass index 		T 0.700 GeneticVariation GWASCAT Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. 28448500 2017
dbSNP: rs2820315
rs2820315
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C1305855
Disease:
Body mass index 		T 0.700 GeneticVariation GWASCAT Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. 28892062 2017
dbSNP: rs2820315
rs2820315
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C4049938
Disease:
Physical Activity Measurement 		T 0.700 GeneticVariation GWASCAT Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. 28448500 2017
dbSNP: rs777696417
rs777696417
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C0149632
Disease:
Abnormality of the bladder 		A 0.700 CausalMutation CLINVAR Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice. 28292896 2017
dbSNP: rs777696417
rs777696417
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C0266200
Disease:
Microcolon 		A 0.700 CausalMutation CLINVAR Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice. 28292896 2017
dbSNP: rs777696417
rs777696417
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C0042781
Disease:
Visceral Myopathy 		A 0.700 CausalMutation CLINVAR Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice. 28292896 2017
dbSNP: rs777696417
rs777696417
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C2931117
Disease:
Fetal megacystis 		A 0.700 CausalMutation CLINVAR Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice. 28292896 2017
dbSNP: rs34091558
rs34091558
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C0425782
Disease:
Breast size 		0.700 GeneticVariation GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
dbSNP: rs2819368
rs2819368
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C0428474
Disease:
Serum LDL cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs2819368
rs2819368
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs2819371
rs2819371
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs2819371
rs2819371
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C0428474
Disease:
Serum LDL cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs2820300
rs2820300
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C0428474
Disease:
Serum LDL cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs2820300
rs2820300
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs2820301
rs2820301
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C0428474
Disease:
Serum LDL cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs2820301
rs2820301
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs34091558
rs34091558
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C1956346
Disease:
Coronary Artery Disease 		0.010 GeneticVariation BEFREE Using epigenomic profiling we recently identified a non-coding regulatory variant, rs34091558, which is in tight linkage disequilibrium (LD) with the lead CAD GWAS variant, rs2820315. 30444878 2018
dbSNP: rs2820315
rs2820315
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C0003850
Disease:
Arteriosclerosis 		0.010 GeneticVariation BEFREE We identified 25 new SNP-CAD associations (P < 5 × 10<sup>-8</sup>, in fixed-effects meta-analysis) from 15 genomic regions, including SNPs in or near genes involved in cellular adhesion, leukocyte migration and atherosclerosis (PECAM1, rs1867624), coagulation and inflammation (PROCR, rs867186 (p.Ser219Gly)) and vascular smooth muscle cell differentiation (LMOD1, rs2820315). 28530674 2017
dbSNP: rs2820315
rs2820315
Entrez Id: 25802
Gene Symbol: LMOD1
LMOD1
CUI: C0004153
Disease:
Atherosclerosis 		0.010 GeneticVariation BEFREE We identified 25 new SNP-CAD associations (P < 5 × 10<sup>-8</sup>, in fixed-effects meta-analysis) from 15 genomic regions, including SNPs in or near genes involved in cellular adhesion, leukocyte migration and atherosclerosis (PECAM1, rs1867624), coagulation and inflammation (PROCR, rs867186 (p.Ser219Gly)) and vascular smooth muscle cell differentiation (LMOD1, rs2820315). 28530674 2017