rs6922269
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Coronary heart disease
0.830
GeneticVariation
BEFREE
We investigated the association between rs6922269 and known metabolic risk factors and survival in two independent cohorts of coronary heart disease patients.
24618918 2014
rs6922269
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Coronary heart disease
0.830
GeneticVariation
BEFREE
The Ch9p21 SNPs rs1333049 (OR 1.17; 95% confidence limits 1.11-1.24) and rs10757274 (OR 1.17; 1.09-1.26), MIA3 rs17465637 (OR 1.10; 1.04-1.15), Ch2q36 rs2943634 (OR 1.08; 1.03-1.14), APC rs383830 (OR 1.10; 1.02, 1.18), MTHFD1L rs6922269 (OR 1.10; 1.03, 1.16), CXCL12 rs501120 (OR 1.12; 1.04, 1.20), and SMAD3 rs17228212 (OR 1.11; 1.05, 1.17) were all associated with CHD risk, but not with the CHD biomarkers and risk factors measured.
21804106 2012
rs6922269
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Coronary heart disease
0.830
GeneticVariation
GWASDB
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
21347282 2011
rs6922269
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Coronary heart disease
0.830
GeneticVariation
BEFREE
Nine loci were statistically associated with incident CHD events in white participants: 9p21 (rs10757278; P=4.7 × 10(-41)), 16q23.1 (rs2549513; P=0.0004), 6p24.1 (rs499818; P=0.0002), 2q36.3 (rs2943634; P=6.7 × 10(-6)), MTHFD1L (rs6922269 , P=5.1 × 10(-10)), APOE (rs429358; P=2.7×10(-18)), ZNF627 (rs4804611; P=5.0 × 10(-8)), CXCL12 (rs501120; P=1.4 × 10(-6)) and LPL (rs268; P=2.7 × 10(-17)).
22042884 2011
rs6922269
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Coronary heart disease
A
0.830
GeneticVariation
GWASDB
Genomewide association analysis of coronary artery disease.
17634449 2007
rs6922269
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Coronary heart disease
A
0.830
GeneticVariation
GWASCAT
Genomewide association analysis of coronary artery disease.
17634449 2007
rs11754661
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Alzheimer's Disease
0.820
GeneticVariation
BEFREE
The rs11754661 polymorphism was associated with AD in t</ span>he ethnic Chinese Han (OR=1.829, 95% CI: 1.277-2.619, P=0.001), and the results were influenced by APOE status.
21741665 2011
rs11754661
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Alzheimer's Disease
0.820
GeneticVariation
BEFREE
The MTHFD1L gene rs11754661 marker is not associated with Alzheimer's disease in a sample of the Spanish population.
21383495 2011
rs11754661
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Alzheimer's Disease
A
0.820
GeneticVariation
GWASCAT
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
20885792 2010
rs11754661
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Alzheimer's Disease
A
0.820
GeneticVariation
GWASDB
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
20885792 2010
rs9397365
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Peripheral Arterial Diseases
G
0.700
GeneticVariation
GWASCAT
Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease.
27082954 2016
rs524732
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Schizophrenia
A
0.700
GeneticVariation
GWASCAT
Genome-wide association study of schizophrenia in Ashkenazi Jews.
26198764 2015
rs2295733
MTHFD1L;MIR12131
Low density lipoprotein cholesterol measurement
0.700
GeneticVariation
GWASDB
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
23063622 2012
rs2295733
MTHFD1L;MIR12131
Serum LDL cholesterol measurement
0.700
GeneticVariation
GWASDB
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
23063622 2012
rs1771798
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Corneal Topography
0.700
GeneticVariation
GWASDB
Association of polymorphisms in the hepatocyte growth factor gene promoter with keratoconus.
22003120 2011
rs6907487
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Coronary Artery Disease
0.700
GeneticVariation
GWASDB
Genomewide association analysis of coronary artery disease.
17634449 2007
rs9371203
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Coronary Artery Disease
0.700
GeneticVariation
GWASDB
Genomewide association analysis of coronary artery disease.
17634449 2007
rs6922269
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Myocardial Infarction
0.040
GeneticVariation
BEFREE
One of them is the marker rs6922269 , which has been suggested as a risk factor for development of MI in Western populations.
25809277 2015
rs6922269
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Myocardial Infarction
0.040
GeneticVariation
BEFREE
No association for MI or lipid levels was found for SNPs rs2943634 and rs6922269 (P-adj > 0.05).
21463265 2011
rs6922269
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Myocardial Infarction
0.040
GeneticVariation
BEFREE
One marker, rs6922269 , in MTHFD1L was significantly protective against MI (OR=0.68, p=0.0035), while the variant rs4977574 in CDKN2A-CDKN2B was significantly associated with MI (OR=1.33, p=0.0086).
22216278 2011
rs6922269
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Myocardial Infarction
0.040
GeneticVariation
BEFREE
The aim of the present case-control study including 324 healthy controls and 296 patients with coronary heart disease from Tunisia, was to assess relation between three polymorphisms previously reported to be strongly associated with coronary heart disease in the Welcome Trust Case Control Consortium (WTCCC) and the German myocardial infarction family studies: locus 9p21.3 (rs 1333049), locus 6q25.1 (rs6922269 ) and 2q36.3 (rs2943634).
19373437 2010
rs6922269
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Acute Chest Syndrome
0.020
GeneticVariation
BEFREE
We conclude, that rs6922269 variant at MTHFD1L gene could be an important prognostic factor for cardiovascular mortality in patients after ACS .
25809277 2015
rs6922269
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Acute Coronary Syndrome
0.020
GeneticVariation
BEFREE
We analyzed the relationship between rs6922269 variant on MTHFD1L gene and (i) risk of the acute coronary syndrome (ACS) in the Czech population and (ii) mortality in 7 years follow up.
25809277 2015
rs6922269
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Coronary Arteriosclerosis
0.020
GeneticVariation
BEFREE
We investigated the association between rs6922269 and known metabolic risk factors and survival in two independent cohorts of coronary heart disease patients.
24618918 2014
rs6922269
×
Entrez Id: 25902
Gene Symbol: MTHFD1L
MTHFD1L
Acute Coronary Syndrome
0.020
GeneticVariation
BEFREE
Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients.
24618918 2014