GREM1, gremlin 1, DAN family BMP antagonist, 26585

N. diseases: 179; N. variants: 8
Disease: Colorectal Carcinoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10318
rs10318
Entrez Id: 26585
Gene Symbol: GREM1
GREM1
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.730 GeneticVariation BEFREE This meta-analysis demonstrated that the rs4779584 and rs10318 polymorphism at 15q13.3 is a risk factor associated with increased CRC/CRA susceptibility, but these associations vary in different ethnic populations. 25475391 2015
dbSNP: rs10318
rs10318
Entrez Id: 26585
Gene Symbol: GREM1
GREM1
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.730 GeneticVariation BEFREE In two of the five genes originally associated with CRC, we found evidence for association in AAs including rs1862748 in CDH1 (OR(Add) = 0.82, P = 0.02) and in GREM1 the SNPs rs10318 (OR(Rec) = 60.1, P = 0.01), rs11632715 (OR(Rec) = 2.36; P = 0.004) and rs12902616 (OR(Rec) = 1.28, P = 0.005), the latter which is in linkage disequilibrium with the previously identified SNP rs4779584. 24753543 2014
dbSNP: rs10318
rs10318
Entrez Id: 26585
Gene Symbol: GREM1
GREM1
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.730 GeneticVariation BEFREE At 15q13.3, rs10318 was associated with CRC in both populations. 20659471 2010
dbSNP: rs10318
rs10318
Entrez Id: 26585
Gene Symbol: GREM1
GREM1
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.730 GeneticVariation GWASDB Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. 19011631 2008