|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
The C825T polymorphism of the G-protein β3 subunit gene and its association with hypertension and stroke: an updated meta-analysis.
|
23799054 |
2013 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
A C825T polymorphism was identified in the gene encoding the G-protein beta3 subunit (GNB3), and an association of the T-allele with hypertension was demonstrated in several studies.
|
15037876 |
2004 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
A polymorphism (C825T) in the gene encoding the G protein beta3 subunit (GNB3) has recently been associated with hypertension and obesity in several populations.
|
12109775 |
2002 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
T allele frequency in overall population showed significant association with hypertension for C825T (0.0134).
|
21473734 |
2011 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
The recently discovered C825T polymorphism of the G-protein beta 3 subunit has been reported to be associated with the development of hypertension and obesity.
|
12384823 |
2002 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
The GNB3 C825T polymorphism as a pharmacogenetic marker in the treatment of hypertension, obesity, and depression.
|
21709600 |
2011 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that the variation within the GNB3 gene may interact with physical activity level to influence obesity status and, together with obesity and physical activity, the GNB3 825C>T variant may influence hypertension prevalence in AAs.
|
17299380 |
2007 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study we tested whether GNB3 C825T polymorphism, previously reported to be associated with hypertension, contributes to predisposition to end-stage renal disease (ESRD).
|
11684796 |
2002 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
G-protein beta3 subunit gene C825T polymorphism is associated with arterial hypertension in Polish patients with type 2 diabetes mellitus.
|
12165748 |
2002 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
The G-protein β 3(GNB3) C825T polymorphism has been linked with hypertension, salt sensitivity and multiple diseases.
|
21198262 |
2010 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
The GNB3 C825T gene polymorphism has recently been identified and associated with hypertension, obesity and left ventricular hypertrophy.
|
12566975 |
2003 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Synergistic Effects of ACE Insertion/Deletion and GNB3 C825T Polymorphisms on the Efficacy of PDE-5 Inhibitor in Patients with Pulmonary Hypertension.
|
26821322 |
2016 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
We assessed whether distributions of 3 single nucleotide polymorphisms in genes coding for components of G protein signaling pathways that have been associated with hypertension differ between women with preeclampsia and normotensive pregnant women; the G protein β3 subunit gene (GNB3) C825T polymorphism (rs5443), the angiotensin II type 1 receptor gene (AGTR1) 3'UTR A1166C polymorphism (rs5186), and the regulator of G protein signaling 2 gene (RGS2) 3'UTR C1114G polymorphism (rs4606).
|
23339167 |
2013 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate the biochemical and genetic background of this disease we investigated the genotypes for two polymorphisms associated with hypertension: TH01, a tetrameric microsatellite in the tyrosine hydroxylase gene and the single nucleotide polymorphism C825T in the GNB3 gene in 116 sudden deaths from MI (78 males, 38 females) and in a control group of 137 deaths from natural causes other than MI (52 males, 85 females).
|
16139102 |
2005 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore our work does not provide evidence in favor of GNB3 C825T being a candidate gene for conferring genetic susceptibility to hypertension or obesity in northern Chinese population.
|
13679998 |
2003 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
This study indicates that the C825T polymorphism is not a significant factor for hypertension or blood pressures in Japanese people.
|
15076154 |
2004 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results from the combined SNP, haplotype and sib-TDT analyses also support the hypothesis that the 825C>T is a susceptibility locus for hypertension, whereas effects of other loci on blood pressure may result from their strong linkage disequilibrium with the 825C>T locus.
|
15226674 |
2004 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, our study suggests that G(-350)A is a potential functional polymorphism that may be related to hypertension, whereas the C825T and C1429T polymorphisms are not associated with hypertension in the northern Chinese Han population.
|
15996174 |
2005 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
The C825T polymorphism of the gene encoding the G-protein beta(3) subunit (GNB3) is associated with increased intracellular signal transduction and arterial hypertension.
|
11244012 |
2001 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
The C825T polymorphism of the gene encoding the human G protein beta-3 subunit (GNB3) is associated with hypertension and obesity.
|
25463071 |
2014 |
|
rs5443
|
GNB3;CDCA3
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
The study provided evidence against the major impact of the GNB3 C825T polymorphism on the increased risk of the development of nephropathy or hypertension in type 2 diabetic patients.
|
10970984 |
2000 |