Conclusion In conclusion, our findings suggest that the H19 rs217727 gene polymorphism contributes to small vessel ischemic stroke susceptibility in the Chinese Han population and may serve as a potential indicator for ischemic stroke susceptibility.
However, rs4929984 is significantly associated with the diastolic blood pressure level of IS patients (additive model: P<sub>adj</sub> = 0.007; dominant model: P<sub>adj</sub> = 0.013), whereas rs217727 is associated with international normalized ratio (additive model: P<sub>adj</sub> = 0.019; recessive model: P<sub>adj</sub> = 0.004), prothrombin time activity level (additive model: P<sub>adj</sub> = 0.026; recessive model: P<sub>adj</sub> = 0.004), and homocysteine level (recessive model: P<sub>adj</sub> = 0.048) in patients with IS.