CD274, CD274 molecule, 29126

N. diseases: 1011; N. variants: 8
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1411262
rs1411262
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C2985280
Disease:
Blood Protein Measurement
C 0.700 GeneticVariation GWASCAT Co-regulatory networks of human serum proteins link genetics to disease. 30072576 2018
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C1306459
Disease:
Primary malignant neoplasm
0.020 GeneticVariation BEFREE The results suggested that there is a strong association between rs4143815 C > G and the cancer risks (G vs. C: OR = 1.386, 95% CI: 1.132-1.696, p = 0.002; GG vs. CG + CC: OR = 1.843 95% CI: 1.300-2.613, p = 0.002; GG + CG vs. CC: OR = 1.280, 95% CI: 1.040-1.576, p = 0.020). 30552042 2019
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C0006826
Disease:
Malignant Neoplasms
0.020 GeneticVariation BEFREE The results suggested that there is a strong association between rs41</span>43815 C > G and the cancer risks (G vs. C: OR = 1.386, 95% CI: 1.132-1.696, p = 0.002; GG vs. CG + CC: OR = 1.843 95% CI: 1.300-2.613, p = 0.002; GG + CG vs. CC: OR = 1.280, 95% CI: 1.040-1.576, p = 0.020). 30552042 2019
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C1306459
Disease:
Primary malignant neoplasm
0.020 GeneticVariation BEFREE In conclusions, the results of this meta-analysis have revealed an association between <i>PD-1</i> rs2227981, rs11568821, rs7421861, as well as <i>PD-L1</i> rs4143815 polymorphisms and overall cancer susceptibility. 31405171 2019
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C0006826
Disease:
Malignant Neoplasms
0.020 GeneticVariation BEFREE In conclusions, the results of this meta-analysis have revealed an association between <i>PD-1</i> rs2227981, rs11568821, rs7421861, as well as <i>PD-L1</i> rs4143815 polymorphisms and overall cancer susceptibility. 31405171 2019
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C0011854
Disease:
Diabetes Mellitus, Insulin-Dependent
0.020 GeneticVariation BEFREE Our results indicate that rs4143815 of PD-L1 is significantly associated with T1DM and may serve as a new biomarker to predict the T1DM susceptibility. 30534571 2018
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma
0.020 GeneticVariation BEFREE Among the three SNPs, the rs4143815 genotype CC was statistically associated with positive 22C3 PD-L1 labeling in NSCLCs. 28851662 2017
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma
0.020 GeneticVariation BEFREE Moreover, the C/C and C/G genotypes of PD-L1 rs4143815 were significantly associated with better ORR and PFS in NSCLC patients treated with nivolumab. 28332580 2017
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C0011854
Disease:
Diabetes Mellitus, Insulin-Dependent
0.020 GeneticVariation BEFREE In addition, the CGG haplotype in PD-L1 associated with T1D</span> (constructed from rs822342, rs2297137 and rs4143815 polymorphisms) showed an OR = 1.44 [1.08 to 1.93]. 24816853 2014
dbSNP: rs2890658
rs2890658
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C0006826
Disease:
Malignant Neoplasms
0.010 GeneticVariation BEFREE No significant association between rs2227982, rs36084323, rs10204525, and rs2890658 polymorphisms and overall cancer risk has been found. 31405171 2019
dbSNP: rs2890658
rs2890658
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C1306459
Disease:
Primary malignant neoplasm
0.010 GeneticVariation BEFREE No significant association between rs2227982, rs36084323, rs10204525, and rs2890658 polymorphisms and overall cancer risk has been found. 31405171 2019
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C0013882
Disease:
Elephantiasis
0.010 GeneticVariation BEFREE We evaluated the frequency of alleles and genotypes of <i>IL-10</i> (rs3024496, rs1800872), <i>IL-10RA</i> (rs3135932), <i>IL-10RB</i> (rs2834167), <i>PD-1</i> (rs2227982, rs10204525), <i>PD-L1</i> (rs4143815), <i>PD-L2</i> (rs7854413), and single-nucleotide polymorphisms (SNPs) in 103 patients with chronic pathology (CP), such as elephantiasis or hydrocele and 106 endemic normal (EN) individuals from a South Indian population living in an area endemic for LF. 30594267 2019
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C0013884
Disease:
Filarial Elephantiases
0.010 GeneticVariation BEFREE We evaluated the frequency of alleles and genotypes of <i>IL-10</i> (rs3024496, rs1800872), <i>IL-10RA</i> (rs3135932), <i>IL-10RB</i> (rs2834167), <i>PD-1</i> (rs2227982, rs10204525), <i>PD-L1</i> (rs4143815), <i>PD-L2</i> (rs7854413), and single-nucleotide polymorphisms (SNPs) in 103 patients with chronic pathology (CP), such as elephantiasis or hydrocele and 106 endemic normal (EN) individuals from a South Indian population living in an area endemic for LF. 30594267 2019
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.010 GeneticVariation BEFREE A polymorphism in the <i>PDL1</i> gene (rs4143815) was the unique potential genetic variant of 10 year BCR (training set: <i>p</i> = 0.003, HR (95% CI) = 0.58 (0.41-0.83); replication set: <i>p</i> = 0.063, HR (95% CI) = 0.52 (0.26-1.04)) that was significantly associated with 5 year BCR (training set: <i>p</i> = 0.009, HR (95% CI) = 0.59 (0.40-0.88); replication set: <i>p</i> = 0.036, HR (95% CI) = 0.39 (0.16-0.94)).No biomarkers of OS were replicated. rs4143815-<i>PDL1</i> arose as a new immunogenetic biomarker of BCR in PCa, giving new insights into the RT/immune system interaction, which could be potentially useful in new approaches using anti-PDL1 therapies for PCa. 31035590 2019
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C0699791
Disease:
Stomach Carcinoma
0.010 GeneticVariation BEFREE Subgroup analysis based on cancer type suggested that PD-L1 rs4143815 C > G might increase the susceptibility to gastric cancer (G vs. C: OR = 1.842, 95% CI: 1.403-2.418, p < 0.001) and bladder cancer (G vs. C: OR = 2.015, 95% CI: 1.556-2.608, p < 0.001), and genotype GG carriers of PD-L1 rs4143815 C > G might have higher risks of HCC (GG vs. CG + CC: OR = 2.226 95% CI: 1.562-3.172, p < 0.001). 30552042 2019
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C0600139
Disease:
Prostate carcinoma
0.010 GeneticVariation BEFREE A polymorphism in the <i>PDL1</i> gene (rs4143815) was the unique potential genetic variant of 10 year BCR (training set: <i>p</i> = 0.003, HR (95% CI) = 0.58 (0.41-0.83); replication set: <i>p</i> = 0.063, HR (95% CI) = 0.52 (0.26-1.04)) that was significantly associated with 5 year BCR (training set: <i>p</i> = 0.009, HR (95% CI) = 0.59 (0.40-0.88); replication set: <i>p</i> = 0.036, HR (95% CI) = 0.39 (0.16-0.94)).No biomarkers of OS were replicated. rs4143815-<i>PDL1</i> arose as a new immunogenetic biomarker of BCR in PCa, giving new insights into the RT/immune system interaction, which could be potentially useful in new approaches using anti-PDL1 therapies for PCa. 31035590 2019
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C0024623
Disease:
Malignant neoplasm of stomach
0.010 GeneticVariation BEFREE Subgroup analysis based on cancer type suggested that PD-L1 rs4143815 C > G might increase the susceptibility to gastric cancer (G vs. C: OR = 1.842, 95% CI: 1.403-2.418, p < 0.001) and bladder cancer (G vs. C: OR = 2.015, 95% CI: 1.556-2.608, p < 0.001), and genotype GG carriers of PD-L1 rs4143815 C > G might have higher risks of HCC (GG vs. CG + CC: OR = 2.226 95% CI: 1.562-3.172, p < 0.001). 30552042 2019
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C1720771
Disease:
Testicular Hydrocele
0.010 GeneticVariation BEFREE We evaluated the frequency of alleles and genotypes of <i>IL-10</i> (rs3024496, rs1800872), <i>IL-10RA</i> (rs3135932), <i>IL-10RB</i> (rs2834167), <i>PD-1</i> (rs2227982, rs10204525), <i>PD-L1</i> (rs4143815), <i>PD-L2</i> (rs7854413), and single-nucleotide polymorphisms (SNPs) in 103 patients with chronic pathology (CP), such as elephantiasis or hydrocele and 106 endemic normal (EN) individuals from a South Indian population living in an area endemic for LF. 30594267 2019
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C0005684
Disease:
Malignant neoplasm of urinary bladder
0.010 GeneticVariation BEFREE Subgroup analysis based on cancer type suggested that PD-L1 rs4143815 C > G might increase the susceptibility to gastric cancer (G vs. C: OR = 1.842, 95% CI: 1.403-2.418, p < 0.001) and bladder cancer (G vs. C: OR = 2.015, 95% CI: 1.556-2.608, p < 0.001), and genotype GG carriers of PD-L1 rs4143815 C > G might have higher risks of HCC (GG vs. CG + CC: OR = 2.226 95% CI: 1.562-3.172, p < 0.001). 30552042 2019
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C0005695
Disease:
Bladder Neoplasm
0.010 GeneticVariation BEFREE Subgroup analysis based on cancer type suggested that PD-L1 rs4143815 C > G might increase the susceptibility to gastric cancer (G vs. C: OR = 1.842, 95% CI: 1.403-2.418, p < 0.001) and bladder cancer (G vs. C: OR = 2.015, 95% CI: 1.556-2.608, p < 0.001), and genotype GG carriers of PD-L1 rs4143815 C > G might have higher risks of HCC (GG vs. CG + CC: OR = 2.226 95% CI: 1.562-3.172, p < 0.001). 30552042 2019
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C0699885
Disease:
Carcinoma of bladder
0.010 GeneticVariation BEFREE Subgroup analysis based on cancer type suggested that PD-L1 rs4143815 C > G might increase the susceptibility to gastric cancer (G vs. C: OR = 1.842, 95% CI: 1.403-2.418, p < 0.001) and bladder cancer (G vs. C: OR = 2.015, 95% CI: 1.556-2.608, p < 0.001), and genotype GG carriers of PD-L1 rs4143815 C > G might have higher risks of HCC (GG vs. CG + CC: OR = 2.226 95% CI: 1.562-3.172, p < 0.001). 30552042 2019
dbSNP: rs17718883
rs17718883
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C2239176
Disease:
Liver carcinoma
0.010 GeneticVariation BEFREE Our results indicated that three functional polymorphisms (rs2297136, rs4143815 and rs17718883) of the PD-L1 gene were associated with HCC risk and prognosis, suggesting that genetic variants of PD-L1 polymorphisms might be a possible prognostic marker for the prediction of HCC risk and development. 29940275 2018
dbSNP: rs2297136
rs2297136
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C2239176
Disease:
Liver carcinoma
0.010 GeneticVariation BEFREE Data revealed that the rs2297136 (C > T) SNP TT (p = 0.03) and rs4143815 (C > G) SNP GG genotypes (p < 0.001) were associated with significantly increased risks of HCC. 29940275 2018
dbSNP: rs2890658
rs2890658
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C2239176
Disease:
Liver carcinoma
0.010 GeneticVariation BEFREE No association was found between rs2890658 (A > C) SNP and HCC risk and this risk was significantly decreased in individuals with the rs17718883 SNP CG + GG genotype (p < 0.001). 29940275 2018
dbSNP: rs4143815
rs4143815
Entrez Id: 29126
Gene Symbol: CD274
CD274
CUI: C0919267
Disease:
ovarian neoplasm
0.010 GeneticVariation BEFREE PD-1 rs2227982 C>T and PD-L1 rs4143815 C>G polymorphisms increased the risk for ovarian cancer. 29171986 2018