GTF2I, general transcription factor IIi, 2969

N. diseases: 249; N. variants: 14
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs117026326
rs117026326
Entrez Id: 2969;101926943
Gene Symbol: GTF2I;LOC101926943
GTF2I;LOC101926943
CUI: C1527336
Disease:
Sjogren's Syndrome 		T 0.800 GeneticVariation GWASCAT A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. 24097066 2013
dbSNP: rs117026326
rs117026326
Entrez Id: 2969;101926943
Gene Symbol: GTF2I;LOC101926943
GTF2I;LOC101926943
CUI: C1527336
Disease:
Sjogren's Syndrome 		T 0.800 GeneticVariation GWASDB A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. 24097066 2013
dbSNP: rs117026326
rs117026326
Entrez Id: 2969;101926943
Gene Symbol: GTF2I;LOC101926943
GTF2I;LOC101926943
CUI: C0151449
Disease:
Primary Sjögren's syndrome 		0.020 GeneticVariation BEFREE The combined analysis identified GTF2I at 7q11.23 (rs117026326: Pcombined = 1.31 × 10(-53), combined odds ratio (ORcombined) = 2.20) as a new susceptibility locus for primary Sjögren's syndrome. 24097066 2013
dbSNP: rs6964833
rs6964833
Entrez Id: 2969
Gene Symbol: GTF2I
GTF2I
CUI: C1314691
Disease:
Age at menarche 		T 0.700 GeneticVariation GWASCAT Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. 25231870 2014
dbSNP: rs117026326
rs117026326
Entrez Id: 2969;101926943
Gene Symbol: GTF2I;LOC101926943
GTF2I;LOC101926943
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic 		0.040 GeneticVariation BEFREE This study demonstrates a significant association between SLE and the GTF2I rs117026326 T allele, GTF2IRD1 rs4717901 C allele. 26320362 2015
dbSNP: rs2527367
rs2527367
Entrez Id: 2969
Gene Symbol: GTF2I
GTF2I
CUI: C1279420
Disease:
Anxiety neurosis (finding) 		0.010 GeneticVariation BEFREE Because of this recent preclinical and clinical identification of a genetic influence on anxiety, we examined whether sequence variation in GTF2I, specifically the single-nucleotide polymorphism rs2527367, interacts with trait and state anxiety to collectively impact neural response to anxiety-laden social stimuli. 26285132 2015
dbSNP: rs2527367
rs2527367
Entrez Id: 2969
Gene Symbol: GTF2I
GTF2I
CUI: C0700613
Disease:
Anxiety state 		0.010 GeneticVariation BEFREE Because of this recent preclinical and clinical identification of a genetic influence on anxiety, we examined whether sequence variation in GTF2I, specifically the single-nucleotide polymorphism rs2527367, interacts with trait and state anxiety to collectively impact neural response to anxiety-laden social stimuli. 26285132 2015
dbSNP: rs117026326
rs117026326
Entrez Id: 2969;101926943
Gene Symbol: GTF2I;LOC101926943
GTF2I;LOC101926943
CUI: C1527336
Disease:
Sjogren's Syndrome 		T 0.800 GeneticVariation GWASCAT Identification of susceptibility gene associated with female primary Sjögren's syndrome in Han Chinese by genome-wide association study. 27503288 2016
dbSNP: rs117026326
rs117026326
Entrez Id: 2969;101926943
Gene Symbol: GTF2I;LOC101926943
GTF2I;LOC101926943
CUI: C1832588
Disease:
Chromosome 11p11.2 Deletion Syndrome 		0.010 GeneticVariation BEFREE We identified rs117026326 on GTF2I with GWAS significance (P = 1.10 × 10<sup>-15</sup>) and rs13079920 on RBMS3 with suggestive significance (P = 2.90 × 10<sup>-5</sup>) associating with PSS in women. 27503288 2016
dbSNP: rs117026326
rs117026326
Entrez Id: 2969;101926943
Gene Symbol: GTF2I;LOC101926943
GTF2I;LOC101926943
CUI: C1849193
Disease:
PEELING SKIN SYNDROME 		0.010 GeneticVariation BEFREE We identified rs117026326 on GTF2I with GWAS significance (P = 1.10 × 10<sup>-15</sup>) and rs13079920 on RBMS3 with suggestive significance (P = 2.90 × 10<sup>-5</sup>) associating with PSS in women. 27503288 2016
dbSNP: rs117026326
rs117026326
Entrez Id: 2969;101926943
Gene Symbol: GTF2I;LOC101926943
GTF2I;LOC101926943
CUI: C0036421
Disease:
Systemic Scleroderma 		0.010 GeneticVariation BEFREE We identified rs117026326 on GTF2I with GWAS significance (P = 1.10 × 10<sup>-15</sup>) and rs13079920 on RBMS3 with suggestive significance (P = 2.90 × 10<sup>-5</sup>) associating with PSS in women. 27503288 2016
dbSNP: rs13227433
rs13227433
Entrez Id: 2969
Gene Symbol: GTF2I
GTF2I
CUI: C0424166
Disease:
Social Anxiety 		0.010 GeneticVariation BEFREE The GTF2I rs13227433 AA genotype, previously associated with lower social anxiety, predicted decreased threat-related amygdala reactivity. 26853120 2017
dbSNP: rs2465936
rs2465936
Entrez Id: 2969;101926943
Gene Symbol: GTF2I;LOC101926943
GTF2I;LOC101926943
CUI: C0596887
Disease:
mathematical ability 		G 0.700 GeneticVariation GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018
dbSNP: rs2718277
rs2718277
Entrez Id: 2969;101926943
Gene Symbol: GTF2I;LOC101926943
GTF2I;LOC101926943
CUI: C0596887
Disease:
mathematical ability 		T 0.700 GeneticVariation GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018
dbSNP: rs34324971
rs34324971
Entrez Id: 2969;101926943
Gene Symbol: GTF2I;LOC101926943
GTF2I;LOC101926943
CUI: C0428883
Disease:
Diastolic blood pressure 		A 0.700 GeneticVariation GWASCAT Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. 30224653 2018
dbSNP: rs35005436
rs35005436
Entrez Id: 2969;101926943
Gene Symbol: GTF2I;LOC101926943
GTF2I;LOC101926943
CUI: C0004238
Disease:
Atrial Fibrillation 		C 0.700 GeneticVariation GWASCAT Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
dbSNP: rs74910854
rs74910854
Entrez Id: 2969;101926943
Gene Symbol: GTF2I;LOC101926943
GTF2I;LOC101926943
CUI: C0004238
Disease:
Atrial Fibrillation 		G 0.700 GeneticVariation GWASCAT Multi-ethnic genome-wide association study for atrial fibrillation. 29892015 2018
dbSNP: rs7795281
rs7795281
Entrez Id: 2969;101926943
Gene Symbol: GTF2I;LOC101926943
GTF2I;LOC101926943
CUI: C0201657
Disease:
C-reactive protein measurement 		A 0.700 GeneticVariation GWASCAT Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. 30388399 2018
dbSNP: rs13238568
rs13238568
Entrez Id: 2969
Gene Symbol: GTF2I
GTF2I
CUI: C0427460
Disease:
Red cell distribution width determination 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs13238568
rs13238568
Entrez Id: 2969
Gene Symbol: GTF2I
GTF2I
CUI: C1304746
Disease:
RDW - Red blood cell distribution width result 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs2527366
rs2527366
Entrez Id: 2969
Gene Symbol: GTF2I
GTF2I
CUI: C1305855
Disease:
Body mass index 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs35005436
rs35005436
Entrez Id: 2969;101926943
Gene Symbol: GTF2I;LOC101926943
GTF2I;LOC101926943
CUI: C1314691
Disease:
Age at menarche 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs36044436
rs36044436
Entrez Id: 2969
Gene Symbol: GTF2I
GTF2I
CUI: C0005823
Disease:
Blood Pressure 		0.700 GeneticVariation GWASCAT Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis. 30940143 2019
dbSNP: rs36044436
rs36044436
Entrez Id: 2969
Gene Symbol: GTF2I
GTF2I
CUI: C0024117
Disease:
Chronic Obstructive Airway Disease 		0.700 GeneticVariation GWASCAT Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis. 30940143 2019
dbSNP: rs7794284
rs7794284
Entrez Id: 2969
Gene Symbol: GTF2I
GTF2I
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019