HGF, hepatocyte growth factor, 3082

N. diseases: 671; N. variants: 22
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs137853235
rs137853235
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C1842342
Disease:
DEAFNESS, AUTOSOMAL RECESSIVE 39 (disorder) 		T 0.700 CausalMutation CLINVAR
dbSNP: rs2286194
rs2286194
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0271183
Disease:
Severe myopia 		0.010 GeneticVariation BEFREE This study supports a strong association between the mild to moderate myopia group and the HGF SNP rs3735520 and the HGF haplotypes rs2286194-rs3735520-rs17501108 and rs12536657-rs2286194, and a moderate association of the extreme high myopia with rs2286194. 19471602 2009
dbSNP: rs3735520
rs3735520
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0271183
Disease:
Severe myopia 		0.010 GeneticVariation BEFREE This study supports a strong association between the mild to moderate myopia group and the HGF SNP rs3735520 and the HGF haplotypes rs2286194-rs3735520-rs17501108 and rs12536657-rs2286194, and a moderate association of the extreme high myopia with rs2286194. 19471602 2009
dbSNP: rs12536657
rs12536657
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0020490
Disease:
Hyperopia 		0.020 GeneticVariation BEFREE After correction for multiple testing, the SNPs rs12536657 (odds ratio [OR], 5.53; 95% confidence interval [CI], 1.14-26.76) and rs5745718 (OR, 2.24; 95% CI, 1.30-3.85) showed significant association with hypermetropia. 20005573 2010
dbSNP: rs10272030
rs10272030
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C4315867
Disease:
Moderate myopia 		0.010 GeneticVariation BEFREE Whereas the SNPs rs1743 (OR, 2.02; 95% CI, 1.19-3.43; P = .009), rs4732402 (OR, 2.03; 95% CI, 1.23-3.36; P = 0.005), rs12536657 (OR, 2.38; 95% CI, 1.40-4.05; P = 0.001), rs10272030 (OR, 2.22; 95% CI, 1.31-3.75; P = 0.003), and rs9642131 (OR, 2.44; 95% CI, 1.43-4.14; P = 0.001) showed significant association with low/moderate myopia. 20005573 2010
dbSNP: rs12536657
rs12536657
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C4315867
Disease:
Moderate myopia 		0.010 GeneticVariation BEFREE Whereas the SNPs rs1743 (OR, 2.02; 95% CI, 1.19-3.43; P = .009), rs4732402 (OR, 2.03; 95% CI, 1.23-3.36; P = 0.005), rs12536657 (OR, 2.38; 95% CI, 1.40-4.05; P = 0.001), rs10272030 (OR, 2.22; 95% CI, 1.31-3.75; P = 0.003), and rs9642131 (OR, 2.44; 95% CI, 1.43-4.14; P = 0.001) showed significant association with low/moderate myopia. 20005573 2010
dbSNP: rs1743
rs1743
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C4315867
Disease:
Moderate myopia 		0.010 GeneticVariation BEFREE Whereas the SNPs rs1743 (OR, 2.02; 95% CI, 1.19-3.43; P = .009), rs4732402 (OR, 2.03; 95% CI, 1.23-3.36; P = 0.005), rs12536657 (OR, 2.38; 95% CI, 1.40-4.05; P = 0.001), rs10272030 (OR, 2.22; 95% CI, 1.31-3.75; P = 0.003), and rs9642131 (OR, 2.44; 95% CI, 1.43-4.14; P = 0.001) showed significant association with low/moderate myopia. 20005573 2010
dbSNP: rs4732402
rs4732402
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C4315867
Disease:
Moderate myopia 		0.010 GeneticVariation BEFREE Whereas the SNPs rs1743 (OR, 2.02; 95% CI, 1.19-3.43; P = .009), rs4732402 (OR, 2.03; 95% CI, 1.23-3.36; P = 0.005), rs12536657 (OR, 2.38; 95% CI, 1.40-4.05; P = 0.001), rs10272030 (OR, 2.22; 95% CI, 1.31-3.75; P = 0.003), and rs9642131 (OR, 2.44; 95% CI, 1.43-4.14; P = 0.001) showed significant association with low/moderate myopia. 20005573 2010
dbSNP: rs5745718
rs5745718
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0020490
Disease:
Hyperopia 		0.010 GeneticVariation BEFREE After correction for multiple testing, the SNPs rs12536657 (odds ratio [OR], 5.53; 95% confidence interval [CI], 1.14-26.76) and rs5745718 (OR, 2.24; 95% CI, 1.30-3.85) showed significant association with hypermetropia. 20005573 2010
dbSNP: rs9642131
rs9642131
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C4315867
Disease:
Moderate myopia 		0.010 GeneticVariation BEFREE Whereas the SNPs rs1743 (OR, 2.02; 95% CI, 1.19-3.43; P = .009), rs4732402 (OR, 2.03; 95% CI, 1.23-3.36; P = 0.005), rs12536657 (OR, 2.38; 95% CI, 1.40-4.05; P = 0.001), rs10272030 (OR, 2.22; 95% CI, 1.31-3.75; P = 0.003), and rs9642131 (OR, 2.44; 95% CI, 1.43-4.14; P = 0.001) showed significant association with low/moderate myopia. 20005573 2010
dbSNP: rs5745709
rs5745709
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0018099
Disease:
Gout 		0.700 GeneticVariation GWASCAT Gout and type 2 diabetes have a mutual inter-dependent effect on genetic risk factors and higher incidences. 22179738 2012
dbSNP: rs5745709
rs5745709
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0003868
Disease:
Arthritis, Gouty 		0.700 GeneticVariation GWASCAT Gout and type 2 diabetes have a mutual inter-dependent effect on genetic risk factors and higher incidences. 22179738 2012
dbSNP: rs549654942
rs549654942
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0936223
Disease:
Metastatic Prostate Carcinoma 		0.010 GeneticVariation BEFREE We also show here that overexpression of PAK4 harbouring a somatic mutation, E329K, increased the HGF-driven motility of metastatic prostate carcinoma cells. 22689056 2013
dbSNP: rs5745642
rs5745642
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0428472
Disease:
Serum HDL cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs5745642
rs5745642
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0392885
Disease:
High density lipoprotein measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs17427817
rs17427817
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0017605
Disease:
Angle Closure Glaucoma 		0.020 GeneticVariation BEFREE Our study suggests that rs5745718 and rs17427817 are associated with a decreased risk of PACG in the Chinese Han population. 23585864 2013
dbSNP: rs17427817
rs17427817
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0017606
Disease:
Primary angle-closure glaucoma 		0.020 GeneticVariation BEFREE Our study suggests that rs5745718 and rs17427817 are associated with a decreased risk of PACG in the Chinese Han population. 23585864 2013
dbSNP: rs3735520
rs3735520
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0017605
Disease:
Angle Closure Glaucoma 		0.010 GeneticVariation BEFREE A comparison of the distributions of the genotypes and alleles of rs3735520 showed no statistically significant differences between the PACG patients and the controls (pc>0.05). 23585864 2013
dbSNP: rs3735520
rs3735520
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0017606
Disease:
Primary angle-closure glaucoma 		0.010 GeneticVariation BEFREE A comparison of the distributions of the genotypes and alleles of rs3735520 showed no statistically significant differences between the PACG patients and the controls (pc>0.05). 23585864 2013
dbSNP: rs5745718
rs5745718
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0017606
Disease:
Primary angle-closure glaucoma 		0.010 GeneticVariation BEFREE Our study suggests that rs5745718 and rs17427817 are associated with a decreased risk of PACG in the Chinese Han population. 23585864 2013
dbSNP: rs5745718
rs5745718
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0017605
Disease:
Angle Closure Glaucoma 		0.010 GeneticVariation BEFREE Our study suggests that rs5745718 and rs17427817 are associated with a decreased risk of PACG in the Chinese Han population. 23585864 2013
dbSNP: rs2286194
rs2286194
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0022578
Disease:
Keratoconus 		0.010 GeneticVariation BEFREE Ten tSNPs were genotyped.Following statistical analysis and multiple testing correction, a statistically significant association was found for the tSNP rs2286194 {p = 1.1×10-(3) Odds Ratio 0.52, 95% CI--0.35, 0.77} for keratoconus. 24416191 2014
dbSNP: rs762140462
rs762140462
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0267663
Disease:
Congenital secretory diarrhea, sodium type (disorder) 		0.010 GeneticVariation BEFREE A Y163C mutation in the SPINT2 gene encoding the serine protease inhibitor Hepatocyte Growth Factor Inhibitor HAI-2 is associated with a congenital sodium diarrhea. 24722141 2014
dbSNP: rs5745752
rs5745752
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE SNPs in TMPRSS3 (rs3814903 and rs11203200), TMPRSS7 (rs1844925), and HGF (rs5745752) associated significantly with breast cancer risk (Ptrend = 0.008-0.042). 25029565 2014
dbSNP: rs5745752
rs5745752
Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE SNPs in TMPRSS3 (rs3814903 and rs11203200), TMPRSS7 (rs1844925), and HGF (rs5745752) associated significantly with breast cancer risk (Ptrend = 0.008-0.042). 25029565 2014