|
rs9273643
|
HLA-DQB1
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
It was also shown that there is an association between T668C mutation and low HLA related risk of IDDM development, the highest frequency of F206L mutation in the EGF domain of L-selectin was observed in relatives with 'protective' HLA DQB1*0602 allele and nonDRB1*03-nonDRB1*04 haplotype, while in subjects with highest risk of IDDM haplotype the frequency of T668C mutation was similar to the controls.
|
11064106 |
2000 |
|
rs9274299
|
HLA-DQB1
|
Schizophrenia
|
|
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
|
28540026 |
2017 |
|
rs9274299
|
HLA-DQB1
|
Child Development Disorders, Pervasive
|
|
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
|
28540026 |
2017 |
|
rs9274390
|
HLA-DQB1
|
Schizophrenia
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
|
28540026 |
2017 |
|
rs9274390
|
HLA-DQB1
|
Child Development Disorders, Pervasive
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
|
28540026 |
2017 |
|
rs9274657
|
HLA-DQB1
|
Child Development Disorders, Pervasive
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
|
28540026 |
2017 |
|
rs9274657
|
HLA-DQB1
|
Schizophrenia
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
|
28540026 |
2017 |
|
rs9273410
|
HLA-DQB1;HLA-DQB1-AS1
|
Asthma
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.
|
30552067 |
2019 |
|
rs9273401
|
HLA-DQB1;HLA-DQB1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility.
|
27189021 |
2016 |
|
rs9274247
|
HLA-DQB1
|
peak expiratory flow (procedure)
|
A |
0.700 |
GeneticVariation |
GWASCAT |
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
|
30804560 |
2019 |
|
rs9274247
|
HLA-DQB1
|
Forced expiratory volume function
|
A |
0.700 |
GeneticVariation |
GWASCAT |
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
|
30804560 |
2019 |
|
rs201043192
|
HLA-DQB1;HLA-DQB1-AS1
|
Forced expiratory volume function
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank.
|
26423011 |
2015 |
|
rs9274600
|
HLA-DQB1
|
Forced expiratory volume function
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank.
|
26423011 |
2015 |
|
rs1063355
|
HLA-DQB1;HLA-DQB1-AS1
|
Rheumatoid Arthritis
|
|
0.700 |
GeneticVariation |
GWASDB |
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
19503088 |
2009 |
|
rs9274659
|
HLA-DQB1
|
Asthma
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
|
31036433 |
2019 |
|
rs2854275
|
HLA-DQB1;HLA-DQB1-AS1
|
Major Depressive Disorder
|
|
0.700 |
GeneticVariation |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
|
rs2854275
|
HLA-DQB1;HLA-DQB1-AS1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
|
rs281862059
|
HLA-DQB1
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
Studies on IDDM5 have led to the discovery of a novel polymorphism 163 A-->G (M55V) in SUMO4 gene, which was found to be associated with T1D patients with Asian origin.
|
17448564 |
2007 |
|
rs9274407
|
HLA-DQB1
|
Chemical and Drug Induced Liver Injury
|
|
0.800 |
GeneticVariation |
GWASCAT |
Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles.
|
21570397 |
2011 |
|
rs9274407
|
HLA-DQB1
|
Chemical and Drug Induced Liver Injury
|
|
0.800 |
GeneticVariation |
GWASDB |
Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles.
|
21570397 |
2011 |
|
rs9273643
|
HLA-DQB1
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of our study was to evaluate the frequency of the L-selectin gene T668C mutation (from thymine to cytosine at position 668) resulted in F206L an amino acid substitution in patients with overt diabetes and their unaffected first degree relatives in comparison to the unselected control population.
|
11064106 |
2000 |
|
rs9273643
|
HLA-DQB1
|
Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of our study was to evaluate the frequency of the L-selectin gene T668C mutation (from thymine to cytosine at position 668) resulted in F206L an amino acid substitution in patients with overt diabetes and their unaffected first degree relatives in comparison to the unselected control population.
|
11064106 |
2000 |
|
rs1063355
|
HLA-DQB1;HLA-DQB1-AS1
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
The HLA-DR/DQ region on chromosome 6p21.3 was also associated with asthma: rs1063355 in the 3' untranslated region of HLA-DQB1 (P = 9.55E-06).
|
20159242 |
2010 |
|
rs9274407
|
HLA-DQB1
|
Drug-Induced Liver Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
The strongest effect was with an HLA class II SNP (rs9274407, P=4.8×10(-14)), which correlated with rs3135388, a tag SNP of HLA-DRB1*1501-DQB1*0602 that was previously associated with AC-DILI.
|
21570397 |
2011 |
|
rs1063355
|
HLA-DQB1;HLA-DQB1-AS1
|
Rheumatoid Arthritis
|
|
0.700 |
GeneticVariation |
GWASDB |
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
|
17804836 |
2007 |