HNF4A, hepatocyte nuclear factor 4 alpha, 3172

N. diseases: 340; N. variants: 74
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4812829
rs4812829
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		A 0.830 GeneticVariation GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
dbSNP: rs4812829
rs4812829
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.830 GeneticVariation BEFREE Among these nine SNPs that previously showed an association with T2DM in Asian Indians, HMG20A (rs7178572) and HNF4A (rs4812829</span>) gene variants showed a significant association with GDM. 28190082 2017
dbSNP: rs4812829
rs4812829
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.830 GeneticVariation BEFREE The aim of the current study was to analyze the effect of six type II diabetes GWAS loci rs3923113 (GRB14), rs16861329 (ST6GAL1), rs1802295 (VPS26A), rs7178572 (HMG20A), rs2028299 (AP3S2) and rs4812829 (HNF4A), and an FTO polymorphism (rs9939609) on obesity. 26395551 2016
dbSNP: rs4812829
rs4812829
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		A 0.830 GeneticVariation GWASCAT Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480 2014
dbSNP: rs4812829
rs4812829
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		A 0.830 GeneticVariation GWASDB Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480 2014
dbSNP: rs4812829
rs4812829
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.830 GeneticVariation GWASDB Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. 23300278 2013
dbSNP: rs4812829
rs4812829
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.830 GeneticVariation BEFREE We genotyped 11,319 Japanese participants (8,318 with type 2 diabetes and 3,001 controls) for each of the 7 SNPs-rs5945326 near DUSP9, rs3923113 near GRB14, rs16861329 in ST6GAL1, rs1802295 in VPS26A, rs7178572 in HMG20A, rs2028299 near AP3S2, and rs4812829 in HNF4A-and examined the association of each of these 7 SNPs with type 2 diabetes by using logistic regression analysis. 23029454 2012
dbSNP: rs4812829
rs4812829
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		A 0.830 GeneticVariation GWASDB Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. 21874001 2011
dbSNP: rs4812829
rs4812829
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		A 0.830 GeneticVariation GWASCAT Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. 21874001 2011
dbSNP: rs1800961
rs1800961
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0392885
Disease:
High density lipoprotein measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs1800961
rs1800961
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0201657
Disease:
C-reactive protein measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs1800961
rs1800961
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0392885
Disease:
High density lipoprotein measurement 		T 0.800 GeneticVariation GWASCAT Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. 30698716 2019
dbSNP: rs1800961
rs1800961
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0392885
Disease:
High density lipoprotein measurement 		T 0.800 GeneticVariation GWASCAT Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. 30926973 2019
dbSNP: rs1800961
rs1800961
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0392885
Disease:
High density lipoprotein measurement 		C 0.800 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs1800961
rs1800961
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0201657
Disease:
C-reactive protein measurement 		C 0.800 GeneticVariation GWASCAT Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. 30388399 2018
dbSNP: rs1800961
rs1800961
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C1445957
Disease:
Serum total cholesterol measurement 		C 0.800 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs1800961
rs1800961
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0392885
Disease:
High density lipoprotein measurement 		T 0.800 GeneticVariation GWASCAT Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. 30275531 2018
dbSNP: rs1800961
rs1800961
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0201657
Disease:
C-reactive protein measurement 		T 0.800 GeneticVariation GWASCAT Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. 30388399 2018
dbSNP: rs587777732
rs587777732
Entrez Id: 3172;100500813
Gene Symbol: HNF4A;MIR3646
HNF4A;MIR3646
CUI: C4014962
Disease:
FANCONI RENOTUBULAR SYNDROME 4 WITH MATURITY-ONSET DIABETES OF THE YOUNG 		T 0.800 CausalMutation CLINVAR Fainting Fanconi syndrome clarified by proxy: a case report. 28693455 2017
dbSNP: rs587777732
rs587777732
Entrez Id: 3172;100500813
Gene Symbol: HNF4A;MIR3646
HNF4A;MIR3646
CUI: C4014962
Disease:
FANCONI RENOTUBULAR SYNDROME 4 WITH MATURITY-ONSET DIABETES OF THE YOUNG 		T 0.800 CausalMutation CLINVAR Hyperinsulinaemic hypoglycaemia, renal Fanconi syndrome and liver disease due to a mutation in the HNF4A gene. 28458902 2017
dbSNP: rs1800961
rs1800961
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0201657
Disease:
C-reactive protein measurement 		T 0.800 GeneticVariation GWASCAT Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation. 27286809 2016
dbSNP: rs1800961
rs1800961
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C1445957
Disease:
Serum total cholesterol measurement 		T 0.800 GeneticVariation GWASCAT Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation. 27286809 2016
dbSNP: rs1800961
rs1800961
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0392885
Disease:
High density lipoprotein measurement 		T 0.800 GeneticVariation GWASCAT Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation. 27286809 2016
dbSNP: rs587777732
rs587777732
Entrez Id: 3172;100500813
Gene Symbol: HNF4A;MIR3646
HNF4A;MIR3646
CUI: C4014962
Disease:
FANCONI RENOTUBULAR SYNDROME 4 WITH MATURITY-ONSET DIABETES OF THE YOUNG 		T 0.800 CausalMutation CLINVAR Hepatocyte Nuclear Factor-4 Alfa Mutation Associated with Hyperinsulinaemic Hypoglycaemia and Atypical Renal Fanconi Syndrome: Expanding the Clinical Phenotype. 27245055 2016
dbSNP: rs1800961
rs1800961
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0392885
Disease:
High density lipoprotein measurement 		C 0.800 GeneticVariation GWASCAT The impact of low-frequency and rare variants on lipid levels. 25961943 2015