|
rs12086634
|
HSD11B1;HSD11B1-AS1
|
Metabolic Syndrome X
|
|
0.040 |
GeneticVariation |
BEFREE |
We conclude that in a South Indian population, a polymorphism of the HSD11B1 gene containing the single-nucleotide polymorphism (SNP) rs12086634 T→G confers increased risk of metabolic syndrome.
|
23869418 |
2013 |
|
rs12086634
|
HSD11B1;HSD11B1-AS1
|
Metabolic Syndrome X
|
|
0.040 |
GeneticVariation |
BEFREE |
HSD11B1 polymorphisms (rs12086634 and rs1000283) were associated with metabolic syndrome among type 2 diabetic subjects and an H6PD polymorphism (rs17368528) was a risk factor for metabolic syndrome in nondiabetic subjects.
|
21869537 |
2011 |
|
rs12086634
|
HSD11B1;HSD11B1-AS1
|
Metabolic Syndrome X
|
|
0.040 |
GeneticVariation |
BEFREE |
We conclude that, in a population of Southern European Caucasian women with and without PCOS, alleles of HSD11B1 containing the two SNPs rs846910 A and rs12086634 T confer increased 11β-HSD1 expression and activity, which associates with the metabolic syndrome.
|
21622477 |
2011 |
|
rs12086634
|
HSD11B1;HSD11B1-AS1
|
Metabolic Syndrome X
|
|
0.040 |
GeneticVariation |
BEFREE |
The results of our study indicated that the HSD11B1 rs12086634 is associated with both T2D and metS, but HSD11B1 rs846910 is associated with only T2D in South Indian population.
|
28750217 |
2017 |
|
rs12086634
|
HSD11B1;HSD11B1-AS1
|
Polycystic Ovary Syndrome
|
|
0.030 |
GeneticVariation |
BEFREE |
Our objective was to investigate a functional polymorphism in HSD11B1 (T-->G in the third intron rs12086634, which associates with lower 11beta-HSD1 activity) in PCOS with and without obesity.
|
16551740 |
2006 |
|
rs12086634
|
HSD11B1;HSD11B1-AS1
|
Polycystic Ovary Syndrome
|
|
0.030 |
GeneticVariation |
BEFREE |
Women who were heterozygous for rs846910 A and homozygous for rs12086634 T (GA, TT genotype) had a higher risk of metabolic syndrome, regardless of the diagnosis of PCOS (odds ratio in the whole cohort=2.77 (95% confidence interval (CI) 1.16-6.67), P=0.023).
|
21622477 |
2011 |
|
rs12086634
|
HSD11B1;HSD11B1-AS1
|
Polycystic Ovary Syndrome
|
|
0.030 |
GeneticVariation |
BEFREE |
Case-control analyses revealed no differences in genotype distribution between PCOS and controls for rs12086634 or rs6688832 (both P = 0.84).
|
16817821 |
2006 |
|
rs12086634
|
HSD11B1;HSD11B1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation |
BEFREE |
The results of our study indicated that the HSD11B1 rs12086634 is associated with both T2D and metS, but HSD11B1 rs846910 is associated with only T2D in South Indian population.
|
28750217 |
2017 |
|
rs12086634
|
HSD11B1;HSD11B1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation |
BEFREE |
The association of common SNPs in HSD11B1 [IVS3-29G/T (rs12086634), IVS4-11120A/G (rs1000283)] and H6PD [R453Q (rs6688832), P554L (rs17368528)], either separately or combined, with type 2 diabetes and metabolic syndrome was examined in 427 Korean subjects with type 2 diabetes and in 358 nondiabetic Korean subjects.
|
21869537 |
2011 |
|
rs846910
|
HSD11B1;HSD11B1-AS1
|
Metabolic Syndrome X
|
|
0.020 |
GeneticVariation |
BEFREE |
The results of our study indicated that the HSD11B1 rs12086634 is associated with both T2D and metS, but HSD11B1 rs846910 is associated with only T2D in South Indian population.
|
28750217 |
2017 |
|
rs846910
|
HSD11B1;HSD11B1-AS1
|
Metabolic Syndrome X
|
|
0.020 |
GeneticVariation |
BEFREE |
We conclude that, in a population of Southern European Caucasian women with and without PCOS, alleles of HSD11B1 containing the two SNPs rs846910 A and rs12086634 T confer increased 11β-HSD1 expression and activity, which associates with the metabolic syndrome.
|
21622477 |
2011 |
|
rs1000283
|
HSD11B1;HSD11B1-AS1
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation |
BEFREE |
HSD11B1 polymorphisms (rs12086634 and rs1000283) were associated with metabolic syndrome</span> among type 2 diabetic subjects and an H6PD polymorphism (rs17368528) was a risk factor for metabolic syndrome in nondiabetic subjects.
|
21869537 |
2011 |
|
rs1000283
|
HSD11B1;HSD11B1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of common SNPs in HSD11B1 [IVS3-29G/T (rs12086634), IVS4-11120A/G (rs1000283)] and H6PD [R453Q (rs6688832), P554L (rs17368528)], either separately or combined, with type 2 diabetes and metabolic syndrome was examined in 427 Korean subjects with type 2 diabetes and in 358 nondiabetic Korean subjects.
|
21869537 |
2011 |
|
rs10082248
|
HSD11B1;HSD11B1-AS1
|
Obesity
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs10082248, rs2298930 and rs4545339 were associated with the risk of obesity in the recessive model (P < 0.05, respectively).
|
24729284 |
2014 |
|
rs11119328
|
HSD11B1;HSD11B1-AS1
|
Euthymic mood
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a significant association of rs11119328 variant genotypes with increased risk for at least one suicide attempt (OR: 7.10, p = 0.049) and an association of variant genotypes of rs11811440 with euthymic mood under optimized pharmacological treatment (OR: 0.05, P = 0.014).
|
31704233 |
2020 |
|
rs11807619
|
HSD11B1;HSD11B1-AS1
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Two out of five tagging SNPs in HSD11B1 were associated with breast cancer (rs11807619, P = 0.006; rs932335, P = 0.0001). rs11807619 and rs932335 were highly correlated (r2 = 0.74) and, when modeled as a haplotype, only haplotypes containing the rs932335 C allele were associated with breast cancer.
|
18611262 |
2008 |
|
rs11807619
|
HSD11B1;HSD11B1-AS1
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
Two out of five tagging SNPs in HSD11B1 were associated with breast cancer (rs11807619, P = 0.006; rs932335, P = 0.0001). rs11807619 and rs932335 were highly correlated (r2 = 0.74) and, when modeled as a haplotype, only haplotypes containing the rs932335 C allele were associated with breast cancer.
|
18611262 |
2008 |
|
rs11811440
|
HSD11B1;HSD11B1-AS1
|
Euthymic mood
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a significant association of rs11119328 variant genotypes with increased risk for at least one suicide attempt (OR: 7.10, p = 0.049) and an association of variant genotypes of rs11811440 with euthymic mood under optimized pharmacological treatment (OR: 0.05, P = 0.014).
|
31704233 |
2020 |
|
rs12086634
|
HSD11B1;HSD11B1-AS1
|
Obesity
|
|
0.010 |
GeneticVariation |
BEFREE |
Our objective was to investigate a functional polymorphism in HSD11B1 (T-->G in the third intron rs12086634, which associates with lower 11beta-HSD1 activity) in PCOS with and without obesity.
|
16551740 |
2006 |
|
rs12086634
|
HSD11B1;HSD11B1-AS1
|
Cone-Rod Dystrophy 2
|
|
0.010 |
GeneticVariation |
BEFREE |
All subjects were genotyped for CRD-related variants in HSD11B1 (rs12086634) and H6PD (rs6688832).
|
16817821 |
2006 |
|
rs12086634
|
HSD11B1;HSD11B1-AS1
|
Cognitive changes
|
|
0.010 |
GeneticVariation |
BEFREE |
We tested the hypothesis that this and 2 other HSD11B1 polymorphisms (rs12086634-G/T and rs846910-A/G) were associated with lifetime cognitive change in humans.
|
16236446 |
2006 |
|
rs12565406
|
HSD11B1;HSD11B1-AS1
|
Non-alcoholic Fatty Liver Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Subjects homozygous for the major allele had an adjusted odds ratio of 2.16 (95% confidence interval [CI] 1.23-3.90) for rs2235543, 2.06 (95% CI 1.08-4.13) for rs12565406, and 1.95 (95% CI 1.13-3.49) for rs4844880 for having nonalcoholic fatty liver disease compared with carriers of the minor allele.
|
27715400 |
2016 |
|
rs2235543
|
HSD11B1;HSD11B1-AS1
|
Non-alcoholic Fatty Liver Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Subjects homozygous for the major allele had an adjusted odds ratio of 2.16 (95% confidence interval [CI] 1.23-3.90) for rs2235543, 2.06 (95% CI 1.08-4.13) for rs12565406, and 1.95 (95% CI 1.13-3.49) for rs4844880 for having nonalcoholic fatty liver disease compared with carriers of the minor allele.
|
27715400 |
2016 |
|
rs2235543
|
HSD11B1;HSD11B1-AS1
|
Hypertensive disease
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs4393158 was associated with the hypertension in log-additive model test (P = 0.037), and glucose abnormal and hypercholesteremia in dominant model test (P < 0.05, respectively), while the rs2235543 was associated with hypercholesteremia in overdominant model test (P = 0.017).
|
24729284 |
2014 |
|
rs2235543
|
HSD11B1;HSD11B1-AS1
|
Hypercholesterolemia
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs4393158 was associated with the hypertension in log-additive model test (P = 0.037), and glucose abnormal and hypercholesteremia in dominant model test (P < 0.05, respectively), while the rs2235543 was associated with hypercholesteremia in overdominant model test (P = 0.017).
|
24729284 |
2014 |