|
rs5072
|
APOA1;APOA1-AS
|
Hypertriglyceridemia
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analysis revealed that rs5072, rs5128 and rs651821 were associated with hypertriglyceridemia, rs5104 and rs651821 were associated with low-HDL cholesterolemia in overall group. rs651821 was associated with hypertriglyceridemia and low-HDL cholesterolemia in both the male and female group.
|
30631647 |
2019 |
|
rs5072
|
APOA1;APOA1-AS
|
Dyslipidemias
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the association of <i>APOA1</i> rs5072 in this gene cluster with dyslipidemia differed between genders; thus, additional studies are needed to confirm this conclusion, and the mechanisms underlying these results warrant further exploration.
|
30631647 |
2019 |
|
rs1217777010
|
APOA1;APOA1-AS
|
Amyloidosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Glu34Lys is the only known charge inversion mutation in apoA-I that causes human amyloidosis.
|
30184436 |
2018 |
|
rs5070
|
APOA1;APOA1-AS
|
Acute Chest Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs670, rs5070 and rs693 polymorphisms are not genetic susceptibility factors for ACS in Mexican population and had no effect on their apolipoprotein concentrations.
|
28992985 |
2018 |
|
rs5070
|
APOA1;APOA1-AS
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
Lipid metabolism alterations contribute to acute coronary syndrome (ACS). rs670, rs5070 and rs693 polymorphisms have shown to modify the risk of cardiovascular disease.
|
28992985 |
2018 |
|
rs5070
|
APOA1;APOA1-AS
|
Acute Coronary Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
Lipid metabolism alterations contribute to acute coronary syndrome (ACS). rs670, rs5070 and rs693 polymorphisms have shown to modify the risk of cardiovascular disease.
|
28992985 |
2018 |
|
rs670
|
APOA1;APOA1-AS
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
Lipid metabolism alterations contribute to acute coronary syndrome (ACS). rs670, rs5070 and rs693 polymorphisms have shown to modify the risk of cardiovascular disease.
|
28992985 |
2018 |
|
rs670
|
APOA1;APOA1-AS
|
Acute Coronary Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
Lipid metabolism alterations contribute to acute coronary syndrome (ACS). rs670, rs5070 and rs693 polymorphisms have shown to modify the risk of cardiovascular disease.
|
28992985 |
2018 |
|
rs670
|
APOA1;APOA1-AS
|
Acute Chest Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs670, rs5070 and rs693 polymorphisms are not genetic susceptibility factors for ACS in Mexican population and had no effect on their apolipoprotein concentrations.
|
28992985 |
2018 |
|
rs1799837
|
APOA1;APOA1-AS
|
Obesity
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers with rs670 G allele were more likely to get low HDL-C disease (OR = 1.46, OR95%CI: 1.118-1.915; P = 0.005); The genotypic and allelic frequencies of rs5069, rs5072, rs7116797, rs2070665, rs1799837 revealed no significant differences between cases and controls (P < 0.05); with reference to normal weight, Waist circumference (WC), Waist-to-hip ratio (WHR) individuals, respectively, general obesity measured by BMI had 2.686 times (OR95%CI: 1.695-4.256; P < 0.01), abdominal obesity measured by WC had 1.925 times (OR95%CI: 1.273-2.910; P = 0.002) and abdominal obesity measured by WHR had 1.640 times (OR95%CI: 1.114-2.416; P = 0.012) risk to get low HDL-C disease; APOA1 rs670 interacted with obesity (no matter general obesity or abdominal obesity) on low HDL-C disease.
|
28969676 |
2017 |
|
rs5069
|
APOA1;APOA1-AS
|
Obesity
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers with rs670 G allele were more likely to get low HDL-C disease (OR = 1.46, OR95%CI: 1.118-1.915; P = 0.005); The genotypic and allelic frequencies of rs5069, rs5072, rs7116797, rs2070665, rs1799837 revealed no significant differences between cases and controls (P < 0.05); with reference to normal weight, Waist circumference (WC), Waist-to-hip ratio (WHR) individuals, respectively, general obesity measured by BMI had 2.686 times (OR95%CI: 1.695-4.256; P < 0.01), abdominal obesity measured by WC had 1.925 times (OR95%CI: 1.273-2.910; P = 0.002) and abdominal obesity measured by WHR had 1.640 times (OR95%CI: 1.114-2.416; P = 0.012) risk to get low HDL-C disease; APOA1 rs670 interacted with obesity (no matter general obesity or abdominal obesity) on low HDL-C disease.
|
28969676 |
2017 |
|
rs5070
|
APOA1;APOA1-AS
|
Large-artery atherosclerosis (embolus/thrombosis)
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggested that genetic polymorphisms of ApoA1 rs5070 A/G may play a role in the susceptibility to LAA among male diabetic patients.
|
28238629 |
2017 |
|
rs5070
|
APOA1;APOA1-AS
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation |
BEFREE |
Apolipoprotein A1 rs5070 A/G polymorphism with stroke subtypes in Taiwan.
|
28238629 |
2017 |
|
rs632153
|
APOA1;APOA1-AS
|
Dyslipidemias
|
|
0.010 |
GeneticVariation |
BEFREE |
Most importantly, the variant rs632153 is involved in elevating TC, LDLC, TG and VLDLs and probably playing a crucial role in the manifestation of dyslipidemia.
|
28610615 |
2017 |
|
rs670
|
APOA1;APOA1-AS
|
Ischemic stroke
|
|
0.010 |
GeneticVariation |
BEFREE |
A significantly increased risk for ischemic stroke was also identified among high-risk haplotypes (C-C-T-A and T-T-C-A) for rs670-rs2854116-rs2854117-rs662799.
|
28635360 |
2017 |
|
rs2070665
|
APOA1;APOA1-AS
|
Dyslipidemias
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings indicate that the polymorphisms in the APOA1 gene (rs670, rs5069, and rs2070665) are not associated with dyslipidemia in the Kazakh population assessed in this study.
|
27173266 |
2016 |
|
rs5069
|
APOA1;APOA1-AS
|
Dyslipidemias
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings indicate that the polymorphisms in the APOA1 gene (rs670, rs5069, and rs2070665) are not associated with dyslipidemia in the Kazakh population assessed in this study.
|
27173266 |
2016 |
|
rs974389711
|
APOA1;APOA1-AS
|
Hyperlipidemia
|
|
0.010 |
GeneticVariation |
BEFREE |
The various genotypes of the ApoA1 G75A SNP influence the efficacy of lipid regulation by pravastatin and policosanol in patients with hyperlipidemia.
|
27323196 |
2016 |
|
rs1384889210
|
APOA1;APOA1-AS
|
Arteriosclerosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Expression of apoA-I(L141R)Pisa or apoA-I(L159R)FIN mutations in mice was associated with increased diet-induced atherosclerosis compared to either WT apoA-I transgenic or apoA-I(-/-) mice.
|
26363436 |
2015 |
|
rs1384889210
|
APOA1;APOA1-AS
|
Atherosclerosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Expression of apoA-I(L141R)Pisa or apoA-I(L159R)FIN mutations in mice was associated with increased diet-induced atherosclerosis compared to either WT apoA-I transgenic or apoA-I(-/-) mice.
|
26363436 |
2015 |
|
rs632153
|
APOA1;APOA1-AS
|
Avascular Necrosis of Femur Head
|
|
0.010 |
GeneticVariation |
BEFREE |
We also identified rs632153 in ApoA1 gene was associated with increased risk of alcohol-induced ONFH using allele model (OR, 1.83; 95% CI, 1.16-2.88; P = 0.008) and log-additive model (adjusted OR, 1.77; 95% CI, 1.00-3.14; P = 0.046), analysis respectively.
|
26617857 |
2015 |
|
rs670
|
APOA1;APOA1-AS
|
Parkinson Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, evaluating rs670 genotype frequencies in 1,930 PD cases versus 997 NCs, the rs670 GG genotype shows a trend toward association (odds ratio: 1.1; P = 0.10) with PD.
|
25227208 |
2015 |
|
rs670
|
APOA1;APOA1-AS
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest that APOA1 rs670 indicate a post-surgery risk of breast cancer disease progression, and that carriers of this SNP may benefit from more advanced disease monitoring and therapy regimens than the current regular standards.
|
23829168 |
2013 |
|
rs670
|
APOA1;APOA1-AS
|
Recurrent tumor
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, rs670 A/A carrying patients had higher risks in both tumor recurrence (HR=3.12, 95% CI=1.29-7.56, p=0.012) and mortality (HR=4.36, 95% CI=1.52-12.47, p=0.006) than patients with no A alleles after adjustments for associated baseline parameters.
|
23829168 |
2013 |
|
rs670
|
APOA1;APOA1-AS
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest that APOA1 rs670 indicate a post-surgery risk of breast cancer disease progression, and that carriers of this SNP may benefit from more advanced disease monitoring and therapy regimens than the current regular standards.
|
23829168 |
2013 |