HTR2A, 5-hydroxytryptamine receptor 2A, 3356

N. diseases: 289; N. variants: 34
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE A statistically significant association between a silent mutation (102T/C) in the serotonin-2A (5-HT2A) receptor gene and schizophrenia has recently been reported in a sample of Japanese patients and healthy controls. 8655141 1996
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. European Multicentre Association Study of Schizophrenia (EMASS) Group. 8622505 1996
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE Our findings are consistent with other recent association studies which argue against the involvement of the 5-HT2a/T102C polymorphism in predisposition to schizophrenia. 9259371 1997
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE Our data do not support an allelic association between the 102T/C polymorphism of the 5-HT2A receptor gene and schizophrenia in Chinese population. 9264136 1997
dbSNP: rs1805055
rs1805055
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease:
Schizophrenia
0.010 GeneticVariation BEFREE Four polymorphisms (two structural changes, Thr25Asn and His4 M52Tyr, and two silent polymorphisms, 102-T/C and 516-C/T) which had previously been found in patients with schizophrenia and control subjects were detected. 9086465 1997
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE Although association studies between MspI polymorphism (T102C) and the 5-HT2a receptor gene and schizophrenia have been reported, their results are still controversial. 9694252 1998
dbSNP: rs6314
rs6314
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease:
Schizophrenia
0.080 GeneticVariation BEFREE The authors examined the frequencies of gene polymorphisms in the 5-HT1A (Arg219Leu) and 5-HT2A (Thr25Asn and His452Tyr) receptor genes in 29 patients previously diagnosed with neuroleptic malignant syndrome, 94 neuroleptic-treated patients with schizophrenia who had no history of neuroleptic malignant syndrome, and 94 healthy comparison subjects. 9734554 1998
dbSNP: rs1805055
rs1805055
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0027849
Disease:
Neuroleptic Malignant Syndrome
0.010 GeneticVariation BEFREE The authors examined the frequencies of gene polymorphisms in the 5-HT1A (Arg219Leu) and 5-HT2A (Thr25Asn and His452Tyr) receptor genes in 29 patients previously diagnosed with neuroleptic malignant syndrome, 94 neuroleptic-treated patients with schizophrenia who had no history of neuroleptic malignant syndrome, and 94 healthy comparison subjects. 9734554 1998
dbSNP: rs6314
rs6314
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0027849
Disease:
Neuroleptic Malignant Syndrome
0.010 GeneticVariation BEFREE The authors examined the frequencies of gene polymorphisms in the 5-HT1A (Arg219Leu) and 5-HT2A (Thr25Asn and His452Tyr) receptor genes in 29 patients previously diagnosed with neuroleptic malignant syndrome, 94 neuroleptic-treated patients with schizophrenia who had no history of neuroleptic malignant syndrome, and 94 healthy comparison subjects. 9734554 1998
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0016053
Disease:
Fibromyalgia
0.050 GeneticVariation BEFREE However, the T102C polymorphism is not directly involved in the aetiology of FM but might be in linkage dysequilibrium with the true functional variant, which has to be unravelled. 10527809 1999
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0525045
Disease:
Mood Disorders
0.040 GeneticVariation BEFREE In the present study, we investigated the possible influence of the T102C polymorphism of the serotonin-2A receptor gene (5-HT2A, 13q14-21) on the symptomatology of mood disorders. 10482339 1999
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0394006
Disease:
Dysequilibrium syndrome
0.010 GeneticVariation BEFREE However, the T102C polymorphism is not directly involved in the aetiology of FM but might be in linkage dysequilibrium with the true functional variant, which has to be unravelled. 10527809 1999
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C1269683
Disease:
Major Depressive Disorder
0.100 GeneticVariation BEFREE Our results suggest that the 102T/C polymorphism in 5-HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:56-60, 2000. 10686553 2000
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE Recently, a 5-HT2A receptor gene T102C polymorphism has been reported to be associated with clinical response to 5-HT2A receptor antagonist in patients with schizophrenia, suggesting this polymorphism of the gene affects the 5-HT2A receptor function. 10781645 2000
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE In the present study, we investigated the potential influence of the T102C polymorphism on the psychopathology of schizophrenia. 10686558 2000
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0041696
Disease:
Unipolar Depression
0.100 GeneticVariation BEFREE Recent studies have shown an association of allele C of the 5-HT2A-T102C polymorphism with suicidal ideation in patients with major depression. 11121191 2000
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C1269683
Disease:
Major Depressive Disorder
0.100 GeneticVariation BEFREE Recent studies have shown an association of allele C of the 5-HT2A-T102C polymorphism with suicidal ideation in patients with major depression. 11121191 2000
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0041696
Disease:
Unipolar Depression
0.100 GeneticVariation BEFREE Our results suggest that the 102T/C polymorphism in 5-HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:56-60, 2000. 10686553 2000
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE Recent studies have also shown an association between the allele C of 102T/C polymorphism in the 5-HT2A receptor gene and schizophrenia. 10686553 2000
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0438696
Disease:
Suicidal
0.080 GeneticVariation BEFREE Recent studies have shown an association of allele C of the 5-HT2A-T102C polymorphism with suicidal ideation in patients with major depression. 11121191 2000
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0438696
Disease:
Suicidal
0.080 GeneticVariation BEFREE Our results suggest that the 102T/C polymorphism in 5-HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:56-60, 2000. 10686553 2000
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0525045
Disease:
Mood Disorders
0.040 GeneticVariation BEFREE Negative association between T102C polymorphism at the 5-HT2A receptor gene and bipolar affective disorders in Singaporean Chinese. 10802129 2000
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C1263846
Disease:
Attention deficit hyperactivity disorder
0.030 GeneticVariation BEFREE One hundred and fifteen families with a total of 143 children diagnosed with ADHD (DSM-IV) were genotyped for the His452 Tyr and the T102C polymorphisms in the serotonin HTR2A receptor gene. 11032388 2000
dbSNP: rs6314
rs6314
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C1263846
Disease:
Attention deficit hyperactivity disorder
0.030 GeneticVariation BEFREE One hundred and fifteen families with a total of 143 children diagnosed with ADHD (DSM-IV) were genotyped for the His452 Tyr and the T102C polymorphisms in the serotonin HTR2A receptor gene. 11032388 2000
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0155626
Disease:
Acute myocardial infarction
0.020 GeneticVariation BEFREE The association of T102C polymorphism of the 5-HT2A receptor gene with non-fatal AMI was statistically significant and independent of other risk factors in males. 10781645 2000