HTR2A, 5-hydroxytryptamine receptor 2A, 3356

N. diseases: 289; N. variants: 34
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1923886
rs1923886
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0239377
Disease:
Arm Pain
0.010 GeneticVariation BEFREE Compared with the no arm pain class, 3 single nucleotide polymorphisms and 1 haplotype, in 4 genes, were associated with membership in the mild arm pain class: COMT rs4633, HTR2A haplotype B02 (composed of rs1923886 and rs7330636), HTR3A rs1985242, and TH rs2070762. 30904518 2019
dbSNP: rs3125
rs3125
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0011581
Disease:
Depressive disorder
0.010 GeneticVariation BEFREE Moreover, the association of rs3125 with brooding could be replicated across the separate subsamples, and remained significant even when controlling for lifetime depression and the Brief Symptom Inventory depression score. 31258491 2019
dbSNP: rs3125
rs3125
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0344315
Disease:
Depressed mood
0.010 GeneticVariation BEFREE Moreover, the association of rs3125 with brooding could be replicated across the separate subsamples, and remained significant even when controlling for lifetime depression and the Brief Symptom Inventory depression score. 31258491 2019
dbSNP: rs3125
rs3125
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0011570
Disease:
Mental Depression
0.010 GeneticVariation BEFREE Moreover, the association of rs3125 with brooding could be replicated across the separate subsamples, and remained significant even when controlling for lifetime depression and the Brief Symptom Inventory depression score. 31258491 2019
dbSNP: rs3125
rs3125
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0154575
Disease:
Rumination Disorders
0.010 GeneticVariation BEFREE We revealed two significant models: both the association of methylation site rs6311 with rumination and that of miRNA binding site rs3125 (supposed to bind miR-1270, miR-1304, miR-202, miR-539 and miR-620) with brooding were a function of childhood adversity, and both interaction findings were significantly present both in the never-depressed and in the ever-depressed group. 31258491 2019
dbSNP: rs6311
rs6311
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0024117
Disease:
Chronic Obstructive Airway Disease
0.010 GeneticVariation BEFREE Our results point a possible role of the A allele of HTR2A (rs6311) in COPD pathogenesis, suggesting that this effect depends partly on tobacco consumption due to a gene-by-environment interaction. 30219683 2019
dbSNP: rs6311
rs6311
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0013473
Disease:
Eating Disorders
0.010 GeneticVariation BEFREE Our results showed an association of rs6311 (A1438G) polymorphism of 5-HTR2A gene with eating disorders, and these polymorphic variants could increase the risk of psychiatric comorbidities. 31199591 2019
dbSNP: rs6311
rs6311
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0002395
Disease:
Alzheimer's Disease
0.010 GeneticVariation BEFREE Homozygous short (SS) genotype-HTTLPR, GG genotype of HTR2A-rs6311 and CC genotype of HTR2A-rs6313 were associated with AD treatment-induced insomnia, while val/met genotype of BDNF-rs6265 and the TT genotype of GSK-3beta-rs5443 reduced it. 31111219 2019
dbSNP: rs6311
rs6311
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C1843013
Disease:
Alzheimer disease, familial, type 3
0.010 GeneticVariation BEFREE Homozygous short (SS) genotype-HTTLPR, GG genotype of HTR2A-rs6311 and CC genotype of HTR2A-rs6313 were associated with AD treatment-induced insomnia, while val/met genotype of BDNF-rs6265 and the TT genotype of GSK-3beta-rs5443 reduced it. 31111219 2019
dbSNP: rs6311
rs6311
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0030193
Disease:
Pain
0.010 GeneticVariation BEFREE The polymorphic allele of SNP rs6311 was more frequent in patients with severe pain (p:0.03). 30973927 2019
dbSNP: rs6311
rs6311
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0154575
Disease:
Rumination Disorders
0.010 GeneticVariation BEFREE We revealed two significant models: both the association of methylation site rs6311 with rumination and that of miRNA binding site rs3125 (supposed to bind miR-1270, miR-1304, miR-202, miR-539 and miR-620) with brooding were a function of childhood adversity, and both interaction findings were significantly present both in the never-depressed and in the ever-depressed group. 31258491 2019
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0013473
Disease:
Eating Disorders
0.010 GeneticVariation BEFREE The aim of the present study was to analyze the association of rs6311 and rs6313 polymorphisms of 5-HTR2A gene with eating disorders in Mexican population, and to evaluate if the polymorphisms of 5-HTR2A gene were associated with comorbidities in eating behavior. 31199591 2019
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C1843013
Disease:
Alzheimer disease, familial, type 3
0.010 GeneticVariation BEFREE Homozygous short (SS) genotype-HTTLPR, GG genotype of HTR2A-rs6311 and CC genotype of HTR2A-rs6313 were associated with AD treatment-induced insomnia, while val/met genotype of BDNF-rs6265 and the TT genotype of GSK-3beta-rs5443 reduced it. 31111219 2019
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0917801
Disease:
Sleeplessness
0.010 GeneticVariation BEFREE Homozygous short (SS) genotype-HTTLPR, GG genotype of HTR2A-rs6311 and CC genotype of HTR2A-rs6313 were associated with AD treatment-induced insomnia, while val/met genotype of BDNF-rs6265 and the TT genotype of GSK-3beta-rs5443 reduced it. 31111219 2019
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0549622
Disease:
Sexual Dysfunction
0.010 GeneticVariation BEFREE After all, according to these findings, -1438A/G, 102T/C, and 5-HTTLPR polymorphisms could be considered as promising pharmacogenetic biomarkers in CIT/SERT treatment in major depressive disorder (MDD) patients to avoid the occurrence of SD. 31792367 2019
dbSNP: rs7322347
rs7322347
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease:
Schizophrenia
0.010 GeneticVariation BEFREE Association of rs4680 <i>COMT</i>, rs6280 <i>DRD3</i>, and rs7322347 <i>5HT2A</i> With Clinical Features of Youth-Onset Schizophrenia. 31798476 2019
dbSNP: rs7330636
rs7330636
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0239377
Disease:
Arm Pain
0.010 GeneticVariation BEFREE Compared with the no arm pain class, 3 single nucleotide polymorphisms and 1 haplotype, in 4 genes, were associated with membership in the mild arm pain class: COMT rs4633, HTR2A haplotype B02 (composed of rs1923886 and rs7330636), HTR3A rs1985242, and TH rs2070762. 30904518 2019
dbSNP: rs7997012
rs7997012
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0041696
Disease:
Unipolar Depression
0.010 GeneticVariation BEFREE We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression. 31721892 2019
dbSNP: rs6311
rs6311
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0013170
Disease:
Drug habituation
0.010 GeneticVariation BEFREE While effects of 5-HTTLPR and of a serotonergic multi-marker score (5-HTTLPR, TPH1(rs1800532), TPH2(rs4570625), HTR1A(rs6295) and HTR2A(rs6311)) on amygdala activation did not withstand correction for multiple regions of interest, we observed a strong correlation of the multi-marker score and habituation in the amygdala, DLPFC, and ACC. 29358097 2018
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0027497
Disease:
Nausea
0.010 GeneticVariation BEFREE The relationship between the serotonin 2A receptor gene -1438A/G and 102T/C polymorphisms and citalopram/sertraline-induced nausea in major depressed patients. 30221791 2018
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0027498
Disease:
Nausea and vomiting
0.010 GeneticVariation BEFREE The 102T/C polymorphism in the HTR2A gene had no significant effect on the nausea/vomiting as a side effect among participants treated with either CIT or SERT. 30221791 2018
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0403823
Disease:
Asthenozoospermia
0.010 GeneticVariation BEFREE Men with HTR2A rs6313 had a higher risk of asthenozoospermia (OR = 2.14; P = 0.04). 29602729 2018
dbSNP: rs643627
rs643627
Entrez Id: 3356;100874082
Gene Symbol: HTR2A;HTR2A-AS1
HTR2A;HTR2A-AS1
CUI: C0005586
Disease:
Bipolar Disorder
0.010 GeneticVariation BEFREE In secondary analyses, HTR2A (rs643627, p = 0.002) and CHL1 (rs4003413, p = 0.002) were found associated with risk for BD, HOMER1 (rs6872497, p = 0.002) with lifetime history of suicide attempt in patients, and RORA with early onset and presence of psychotic features in BD. 30178121 2018
dbSNP: rs17069005
rs17069005
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0028754
Disease:
Obesity
0.010 GeneticVariation BEFREE Finally, we identified another two genetic variants, namely, rs17069005 in HTR2A gene and rs3776511 in SLC6A3A gene were associated with obesity at last follow-up. 27228958 2017
dbSNP: rs1923885
rs1923885
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C1269683
Disease:
Major Depressive Disorder
0.010 GeneticVariation BEFREE Younger age, alleles rs6296-C, rs6298-T and rs1923885-C, and haplotype CT were associated with a greater risk of MDD. 28007644 2017