HTR2A, 5-hydroxytryptamine receptor 2A, 3356

N. diseases: 289; N. variants: 34
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0011581
Disease:
Depressive disorder
0.050 GeneticVariation BEFREE Associations between suicidal ideation and 5-HTTLPR, STin2 VNTR, 5-HTR2a 1438A/G, and 5-HTR2a 102T/C genotypes were estimated using logistic regression models, and gene-gene interactions were investigated using the generalized multifactor dimensionality reduction method after adjustment for potential covariates, including depression. 23973249 2014
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0011581
Disease:
Depressive disorder
0.050 GeneticVariation BEFREE To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV. 23157339 2013
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0011581
Disease:
Depressive disorder
0.050 GeneticVariation BEFREE 5-HT2A receptor gene polymorphism rs6313 was associated with 5-HT2A receptor binding potential, with the ability of individuals to use environmental support in order to prevent depression, and with sleep improvement after antidepressant treatment with mirtazapine. 18801406 2008
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0011581
Disease:
Depressive disorder
0.050 GeneticVariation BEFREE Reports have shown an association of a serotonin-2A receptor (HTR2A) gene T102C polymorphism with AD + P and with depression during AD. 17525976 2007
dbSNP: rs6313
rs6313
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0011581
Disease:
Depressive disorder
0.050 GeneticVariation BEFREE The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5-HT2A and serotonin transporter linked polymorphic region -5-HTTLPR- of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E (ApoE) and between themselves, in a sample of 208 sporadic AD patients and 116 normal controls from Italy. 17183148 2006
dbSNP: rs6311
rs6311
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0011581
Disease:
Depressive disorder
0.030 GeneticVariation BEFREE Our results provide further evidence for the involvement of <i>SLC6A4</i> rs4795541 and <i>HTR2A</i> rs6311 polymorphisms in the pathophysiology of depressive disorders in IBS patients. 28951738 2017
dbSNP: rs6311
rs6311
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0011581
Disease:
Depressive disorder
0.030 GeneticVariation BEFREE Based on previous studies indicating that a single nucleotide polymorphism in the serotonin 2A receptor gene [<i>HTR2A</i> rs6311 guanine (G) vs. adenine (A)] is associated with sensitivity to emotional stimuli and several mental disorders such as depression, we predicted that the polymorphism might be associated with the effect of sharing happiness. 29311795 2017
dbSNP: rs6311
rs6311
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0011581
Disease:
Depressive disorder
0.030 GeneticVariation BEFREE The T allele of the promoter variant, rs6311 (C>T), of the 5-HT2A gene has been shown to increase the 5-HT2A expression in vitro and to be associated with anxiety and depressive disorders. 27912162 2017
dbSNP: rs3125
rs3125
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0011581
Disease:
Depressive disorder
0.010 GeneticVariation BEFREE Moreover, the association of rs3125 with brooding could be replicated across the separate subsamples, and remained significant even when controlling for lifetime depression and the Brief Symptom Inventory depression score. 31258491 2019
dbSNP: rs6314
rs6314
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0011581
Disease:
Depressive disorder
0.010 GeneticVariation BEFREE There was no significant association between rs6314 (C/C versus T carriers) and severity of depression. 24968012 2014
dbSNP: rs75634836
rs75634836
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0011581
Disease:
Depressive disorder
0.010 GeneticVariation BEFREE To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV. 23157339 2013
dbSNP: rs7997012
rs7997012
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0011581
Disease:
Depressive disorder
0.010 GeneticVariation BEFREE The HTR2A-rs7997012 is worthy of further investigation in studies examining factors that are related to depression course and outcome. 23537781 2013