HTR2B, 5-hydroxytryptamine receptor 2B, 3357

N. diseases: 61; N. variants: 4
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6736017
rs6736017
Entrez Id: 3357;5707
Gene Symbol: HTR2B;PSMD1
HTR2B;PSMD1
CUI: C0202236
Disease:
Triglycerides measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs6736017
rs6736017
Entrez Id: 3357;5707
Gene Symbol: HTR2B;PSMD1
HTR2B;PSMD1
CUI: C0428474
Disease:
Serum LDL cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs6736017
rs6736017
Entrez Id: 3357;5707
Gene Symbol: HTR2B;PSMD1
HTR2B;PSMD1
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs79874540
rs79874540
Entrez Id: 3357;5707
Gene Symbol: HTR2B;PSMD1
HTR2B;PSMD1
CUI: C0021125
Disease:
Impulsive Behavior 		0.020 GeneticVariation BEFREE No association between suicides and MAOA-uVNTR and HTR2B Q20*, which have been previously connected to violent and impulsive behavior, was detected. 28608626 2017
dbSNP: rs79874540
rs79874540
Entrez Id: 3357;5707
Gene Symbol: HTR2B;PSMD1
HTR2B;PSMD1
CUI: C0021125
Disease:
Impulsive Behavior 		0.020 GeneticVariation BEFREE Regression analyses showed that among the HTR2B Q20* carriers, temperamental traits resembled a passive-dependent personality profile, and the presence of the HTR2B Q20* predicted impulsive and aggressive behaviors particularly under the influence of alcohol. 26575222 2015
dbSNP: rs6736017
rs6736017
Entrez Id: 3357;5707
Gene Symbol: HTR2B;PSMD1
HTR2B;PSMD1
CUI: C0021125
Disease:
Impulsive Behavior 		0.010 GeneticVariation BEFREE In our population, the risk effect of HTR2B rs6736017 appeared to be specific to individuals with crack use disorders rather than being driven by impulsivity or ADHD alone. 30608182 2019
dbSNP: rs79874540
rs79874540
Entrez Id: 3357;5707
Gene Symbol: HTR2B;PSMD1
HTR2B;PSMD1
CUI: C0020459
Disease:
Hyperinsulinism 		0.010 GeneticVariation BEFREE The HTR2B Q20* allele and testosterone predicted lower BMI independently, but an interaction between HTR2B Q20* and testosterone lead to increased insulin sensitivity among HTR2B Q20* carriers with low testosterone levels. 27420381 2016
dbSNP: rs79874540
rs79874540
Entrez Id: 3357;5707
Gene Symbol: HTR2B;PSMD1
HTR2B;PSMD1
CUI: C0003431
Disease:
Antisocial Personality Disorder 		0.010 GeneticVariation BEFREE By contrast, being an ASPD HTR2B Q20* carrier appeared to be preventive of these pathophysiologies. 27420381 2016
dbSNP: rs79874540
rs79874540
Entrez Id: 3357;5707
Gene Symbol: HTR2B;PSMD1
HTR2B;PSMD1
CUI: C0564567
Disease:
Impulsive character (finding) 		0.010 GeneticVariation BEFREE Regression analyses showed that among the HTR2B Q20* carriers, temperamental traits resembled a passive-dependent personality profile, and the presence of the HTR2B Q20* predicted impulsive and aggressive behaviors particularly under the influence of alcohol. 26575222 2015
dbSNP: rs10194776
rs10194776
Entrez Id: 3357;5707
Gene Symbol: HTR2B;PSMD1
HTR2B;PSMD1
CUI: C3714756
Disease:
Intellectual Disability 		0.010 GeneticVariation BEFREE Two polymorphisms in the HTR2B gene, rs10194776 and rs16827801, were associated with IQ (P=0.0004 and 0.003, respectively), ID (P=0.02 and 0.03) and LD (P=0.04 and 0.004). 24887447 2014
dbSNP: rs16827801
rs16827801
Entrez Id: 3357;5707
Gene Symbol: HTR2B;PSMD1
HTR2B;PSMD1
CUI: C3714756
Disease:
Intellectual Disability 		0.010 GeneticVariation BEFREE Two polymorphisms in the HTR2B gene, rs10194776 and rs16827801, were associated with IQ (P=0.0004 and 0.003, respectively), ID (P=0.02 and 0.03) and LD (P=0.04 and 0.004). 24887447 2014