FFAR4, free fatty acid receptor 4, 338557

N. diseases: 67; N. variants: 20
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs116454156
rs116454156
Entrez Id: 338557
Gene Symbol: FFAR4
FFAR4
CUI: C0028754
Disease:
Obesity 		0.040 GeneticVariation BEFREE In humans, the loss of function p.R270H variant of the gene FFAR4 has been associated with a lower protein activity, an increased risk of obesity and higher fasting plasma glucose levels. 27212621 2016
dbSNP: rs116454156
rs116454156
Entrez Id: 338557
Gene Symbol: FFAR4
FFAR4
CUI: C0028754
Disease:
Obesity 		0.040 GeneticVariation BEFREE The p.R270H variant did not affect β-arrestin recruitment. p.R270H was not associated with increased risk of obesity nor increased fasting plasma glucose levels in the Danish study populations. 27068006 2016
dbSNP: rs116454156
rs116454156
Entrez Id: 338557
Gene Symbol: FFAR4
FFAR4
CUI: C0028754
Disease:
Obesity 		0.040 GeneticVariation BEFREE We investigated whether the R270H variant could play a role in determining liver injury in children and adolescents with obesity. 25250621 2014
dbSNP: rs116454156
rs116454156
Entrez Id: 338557
Gene Symbol: FFAR4
FFAR4
CUI: C0028754
Disease:
Obesity 		0.040 GeneticVariation BEFREE Furthermore, the p.R270H variant increases the risk of obesity in European populations. 22343897 2012
dbSNP: rs116454156
rs116454156
Entrez Id: 338557
Gene Symbol: FFAR4
FFAR4
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.020 GeneticVariation BEFREE Interaction between GPR120 p.R270H loss-of-function variant and dietary fat intake on incident type 2 diabetes risk in the D.E.S.I.R. study. 27212621 2016
dbSNP: rs3758539
rs3758539
Entrez Id: 5950;338557
Gene Symbol: RBP4;FFAR4
RBP4;FFAR4
CUI: C0085207
Disease:
Gestational Diabetes 		0.020 GeneticVariation BEFREE The association between RBP4 rs3758539 polymorphism and GDM risk was not confirmed. 26975349 2016
dbSNP: rs116454156
rs116454156
Entrez Id: 338557
Gene Symbol: FFAR4
FFAR4
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.020 GeneticVariation BEFREE This study does not exclude that other coding mutations in FFAR4 with stronger functional effect than p.R270H may be associated with T2D. 26025001 2015
dbSNP: rs3758539
rs3758539
Entrez Id: 5950;338557
Gene Symbol: RBP4;FFAR4
RBP4;FFAR4
CUI: C0085207
Disease:
Gestational Diabetes 		0.020 GeneticVariation BEFREE However, we identified two variants rs3758539 and rs34571439 associated with insulin levels and insulin resistance in women with previous GDM. 24665145 2014
dbSNP: rs370579379
rs370579379
Entrez Id: 5950;338557
Gene Symbol: RBP4;FFAR4
RBP4;FFAR4
CUI: C0007286
Disease:
Carpal Tunnel Syndrome 		0.010 GeneticVariation BEFREE Consistent results were observed for TTR disease-causing mutation Val122Ile (rs76992529) with respect to carpal tunnel syndrome (p = 6.41 × 10<sup>-6</sup>) and mononeuropathies of upper limbs (p = 1.22 × 10<sup>-5</sup>). 31659433 2019
dbSNP: rs370579379
rs370579379
Entrez Id: 5950;338557
Gene Symbol: RBP4;FFAR4
RBP4;FFAR4
CUI: C0494491
Disease:
Mononeuropathies 		0.010 GeneticVariation BEFREE Consistent results were observed for TTR disease-causing mutation Val122Ile (rs76992529) with respect to carpal tunnel syndrome (p = 6.41 × 10<sup>-6</sup>) and mononeuropathies of upper limbs (p = 1.22 × 10<sup>-5</sup>). 31659433 2019
dbSNP: rs7091052
rs7091052
Entrez Id: 5950;338557
Gene Symbol: RBP4;FFAR4
RBP4;FFAR4
CUI: C0085207
Disease:
Gestational Diabetes 		0.010 GeneticVariation BEFREE <i>RBP4</i> rs7091052 was significantly associated with GDM risk. 30805369 2019
dbSNP: rs3758539
rs3758539
Entrez Id: 5950;338557
Gene Symbol: RBP4;FFAR4
RBP4;FFAR4
CUI: C0242339
Disease:
Dyslipidemias 		0.010 GeneticVariation BEFREE Analysis of 1489 subjects (26.9% HDL-C dyslipidemia) identified rs3758539, a non-coding variant in the 5'UTR of RBP4, to be associated with HDL-C dyslipidemia (odds ratio = 1.45, 95% confidence interval = 1.08-1.97, p = 0.01). 30497399 2018
dbSNP: rs370579379
rs370579379
Entrez Id: 5950;338557
Gene Symbol: RBP4;FFAR4
RBP4;FFAR4
CUI: C0018802
Disease:
Congestive heart failure 		0.010 GeneticVariation BEFREE This clinical algorithm may be useful for identification of ATTR V122I amyloidosis in elderly African American patients with HF. 28196196 2017
dbSNP: rs370579379
rs370579379
Entrez Id: 5950;338557
Gene Symbol: RBP4;FFAR4
RBP4;FFAR4
CUI: C0002726
Disease:
Amyloidosis 		0.010 GeneticVariation BEFREE This clinical algorithm may be useful for identification of ATTR V122I amyloidosis in elderly African American patients with HF. 28196196 2017
dbSNP: rs370579379
rs370579379
Entrez Id: 5950;338557
Gene Symbol: RBP4;FFAR4
RBP4;FFAR4
CUI: C0018801
Disease:
Heart failure 		0.010 GeneticVariation BEFREE This clinical algorithm may be useful for identification of ATTR V122I amyloidosis in elderly African American patients with HF. 28196196 2017
dbSNP: rs370579379
rs370579379
Entrez Id: 5950;338557
Gene Symbol: RBP4;FFAR4
RBP4;FFAR4
CUI: C4531196
Disease:
Transthyretin cardiac amyloidosis 		0.010 GeneticVariation BEFREE This clinical algorithm may be useful for identification of ATTR V122I amyloidosis in elderly African American patients with HF. 28196196 2017
dbSNP: rs3758538
rs3758538
Entrez Id: 5950;338557
Gene Symbol: RBP4;FFAR4
RBP4;FFAR4
CUI: C0028754
Disease:
Obesity 		0.010 GeneticVariation BEFREE We found SNP rs3758538 to be associated with obesity (p = 0.007). 26611784 2016
dbSNP: rs10882272
rs10882272
Entrez Id: 338557
Gene Symbol: FFAR4
FFAR4
CUI: C3887461
Disease:
Head and Neck Carcinoma 		0.010 GeneticVariation BEFREE TTR rs1667255 was associated with serum retinol levels; however, neither TTR rs1667255 nor RBP4 rs10882272 was associated with HNC risk. 26131827 2015
dbSNP: rs10882272
rs10882272
Entrez Id: 338557
Gene Symbol: FFAR4
FFAR4
CUI: C0278996
Disease:
Malignant Head and Neck Neoplasm 		0.010 GeneticVariation BEFREE TTR rs1667255 was associated with serum retinol levels; however, neither TTR rs1667255 nor RBP4 rs10882272 was associated with HNC risk. 26131827 2015
dbSNP: rs34571439
rs34571439
Entrez Id: 5950;338557
Gene Symbol: RBP4;FFAR4
RBP4;FFAR4
CUI: C0085207
Disease:
Gestational Diabetes 		0.010 GeneticVariation BEFREE However, we identified two variants rs3758539 and rs34571439 associated with insulin levels and insulin resistance in women with previous GDM. 24665145 2014
dbSNP: rs7094671
rs7094671
Entrez Id: 5950;338557
Gene Symbol: RBP4;FFAR4
RBP4;FFAR4
CUI: C1956346
Disease:
Coronary Artery Disease 		0.010 GeneticVariation BEFREE Polymorphisms at r</span>s7094671 were found to associate with CAD using either a dominant or recessive model (OR, 95% CI: 1.97, 1.38-2.81; 3.81, 1.53-9.51, respectively). 25479076 2014
dbSNP: rs3758539
rs3758539
Entrez Id: 5950;338557
Gene Symbol: RBP4;FFAR4
RBP4;FFAR4
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.010 GeneticVariation BEFREE Studies in adults identified the -803 G>A promoter polymorphism (rs3758539) in the RBP4 gene (RBP4) as a functional variant conferring an increased risk for obesity and type 2 diabetes. 22068556 2011
dbSNP: rs3758539
rs3758539
Entrez Id: 5950;338557
Gene Symbol: RBP4;FFAR4
RBP4;FFAR4
CUI: C0028754
Disease:
Obesity 		0.010 GeneticVariation BEFREE Studies in adults identified the -803 G>A promoter polymorphism (rs3758539) in the RBP4 gene (RBP4) as a functional variant conferring an increased risk for obesity and type 2 diabetes. 22068556 2011
dbSNP: rs3758538
rs3758538
Entrez Id: 5950;338557
Gene Symbol: RBP4;FFAR4
RBP4;FFAR4
CUI: C0020557
Disease:
Hypertriglyceridemia 		0.010 GeneticVariation BEFREE In Mendelian randomization analysis, the observed effect size of association between rs3758538 and hypertriglyceridemia was different from the expected effect size (P = 0.0213). 19287041 2009
dbSNP: rs121918584
rs121918584
Entrez Id: 5950;338557
Gene Symbol: RBP4;FFAR4
RBP4;FFAR4
CUI: C0856901
Disease:
Retinol Deficiency 		0.010 GeneticVariation BEFREE Biochemical basis for retinol deficiency induced by the I41N and G75D mutations in human plasma retinol-binding protein. 16157297 2005