IDE, insulin degrading enzyme, 3416

N. diseases: 71; N. variants: 19
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs139550538
rs139550538
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C1862939
Disease:
AMYOTROPHIC LATERAL SCLEROSIS 1
0.700 GeneticVariation GWASCAT Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis. 27244217 2016
dbSNP: rs139550538
rs139550538
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C1862941
Disease:
Amyotrophic Lateral Sclerosis, Sporadic
0.700 GeneticVariation GWASCAT Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis. 27244217 2016
dbSNP: rs139550538
rs139550538
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C3542025
Disease:
AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE
0.700 GeneticVariation GWASCAT Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis. 27244217 2016
dbSNP: rs139550538
rs139550538
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C1842675
Disease:
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
0.700 GeneticVariation GWASCAT Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis. 27244217 2016
dbSNP: rs2421943
rs2421943
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASDB A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. 17460697 2007
dbSNP: rs2251101
rs2251101
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0002395
Disease:
Alzheimer's Disease
0.020 GeneticVariation BEFREE We found that weak connections existed between rs4646953 (TT vs. CC: z = 2.24, p = 0.025, OR = 1.536) and AD, but no significant associations have been found between other IDE gene single nucleotide polymorphisms of rs4646953, rs2251101 and rs1544210 with AD. 25105907 2015
dbSNP: rs4646953
rs4646953
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0002395
Disease:
Alzheimer's Disease
0.020 GeneticVariation BEFREE We found that weak connections existed between rs4646953 (TT vs. CC: z = 2.24, p = 0.025, OR = 1.536) and AD, but no significant associations have been found between other IDE gene single nucleotide polymorphisms of rs4646953, rs2251101 and rs1544210 with AD. 25105907 2015
dbSNP: rs1887922
rs1887922
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0002395
Disease:
Alzheimer's Disease
0.020 GeneticVariation BEFREE The C allele of rs1887922 conferred a higher risk of AD under the dominant genetics model (adjusted p=0.001, OR=2.719, 95% CI=1.472-5.022). 22502914 2012
dbSNP: rs1887922
rs1887922
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0002395
Disease:
Alzheimer's Disease
0.020 GeneticVariation BEFREE We examined associations of three IDE polymorphisms (IDE2, rs4646953; IDE7, rs2251101 and IDE9, rs1887922) with AD, Aβ42 plasma level and T2DM risk in the longitudinal Vienna Transdanube Aging (VITA) study cohort. 22107728 2011
dbSNP: rs1887922
rs1887922
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE We examined associations of three IDE polymorphisms (IDE2, rs4646953; IDE7, rs2251101 and IDE9, rs1887922) with AD, Aβ42 plasma level and T2DM risk in the longitudinal Vienna Transdanube Aging (VITA) study cohort. 22107728 2011
dbSNP: rs2251101
rs2251101
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0002395
Disease:
Alzheimer's Disease
0.020 GeneticVariation BEFREE We examined associations of three IDE polymorphisms (IDE2, rs4646953; IDE7, rs2251101 and IDE9, rs1887922) with AD, Aβ42 plasma level and T2DM risk in the longitudinal Vienna Transdanube Aging (VITA) study cohort. 22107728 2011
dbSNP: rs2251101
rs2251101
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE We examined associations of three IDE polymorphisms (IDE2, rs4646953; IDE7, rs2251101 and IDE9, rs1887922) with AD, Aβ42 plasma level and T2DM risk in the longitudinal Vienna Transdanube Aging (VITA) study cohort. 22107728 2011
dbSNP: rs4646953
rs4646953
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0002395
Disease:
Alzheimer's Disease
0.020 GeneticVariation BEFREE We examined associations of three IDE polymorphisms (IDE2, rs4646953; IDE7, rs2251101 and IDE9, rs1887922) with AD, Aβ42 plasma level and T2DM risk in the longitudinal Vienna Transdanube Aging (VITA) study cohort. 22107728 2011
dbSNP: rs1887922
rs1887922
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE We verified associations of two IDE polymorphisms (rs1887922 and rs2149632) with T2DM risk in two independent German cohorts and evaluated in detail the association of common variants with insulin metabolism and glycemic traits. 19809796 2009
dbSNP: rs2251101
rs2251101
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE Furthermore, the risk alleles from TCF7L2 rs7903146 polymorphism either with IDE rs2251101 polymorphism (p=0.0257, OR=1.398) or with HHEX rs1544210 polymorphism (p=0.0024, OR=1.514) were significantly associated with T2D. 19053027 2009
dbSNP: rs5786996
rs5786996
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0494463
Disease:
Alzheimer Disease, Late Onset
0.010 GeneticVariation BEFREE This strategy identified three 3'UTR SNPs, rs10876135, rs5848, and rs5786996 that may alter the respective binding sites for the miRNAs hsa-miR-197-5p, hsa-miR-185-5p, and hsa-miR-34a-5p, all of which are upregulated in LOAD. 28286146 2017
dbSNP: rs139550538
rs139550538
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.010 GeneticVariation BEFREE Among the 4256 patients included in the analysis (2589 male [60.8%] and 1667 female [39.2%]; mean [SD] age at onset, 59 [12] years), the following 2 novel loci were significantly associated with ALS survival: at 10q23 (rs139550538; P = 1.87 × 10-9) and in the CAMTA1 gene at 1p36 (rs2412208, P = 3.53 × 10-8). 27244217 2016
dbSNP: rs1887922
rs1887922
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0494463
Disease:
Alzheimer Disease, Late Onset
0.010 GeneticVariation BEFREE These results demonstrate that the polymorphisms rs1887922 and rs1999764 of the IDE gene are associated with LOAD susceptibility in the Xinjiang Han population. 25414272 2015
dbSNP: rs1999764
rs1999764
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0494463
Disease:
Alzheimer Disease, Late Onset
0.010 GeneticVariation BEFREE These results demonstrate that the polymorphisms rs1887922 and rs1999764</span> of the IDE gene are associated with LOAD susceptibility in the Xinjiang Han population. 25414272 2015
dbSNP: rs1832196
rs1832196
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0002395
Disease:
Alzheimer's Disease
0.010 GeneticVariation BEFREE However, for the rs1832196 polymorphism, significant association with AD was found by the dominant model in overall and subgroup analysis. 23416320 2013
dbSNP: rs3758505
rs3758505
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0002395
Disease:
Alzheimer's Disease
0.010 GeneticVariation BEFREE Results suggested that rs3758505 polymorphism was unlikely to be associated with genetic susceptibility of AD based on the current published studies. 23416320 2013
dbSNP: rs6583817
rs6583817
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE IDE (rs6583817) polymorphism and type 2 diabetes differentially modify executive function in older adults. 23597493 2013
dbSNP: rs7100623
rs7100623
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE Notably, rs7100623 in HHEX/IDE was associated with HbA1c (β = 0.03; P < 0.0001) and type 2 diabetes (β = 0.326; P = 0.0002), underscoring substantial impact on glucose control. 23512735 2013
dbSNP: rs3781239
rs3781239
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0002395
Disease:
Alzheimer's Disease
0.010 GeneticVariation BEFREE A single nucleotide polymorphism (SNP) in the insulin degrading enzyme gene (IDE), rs3781239, showed a significant association with AD. 20880607 2012
dbSNP: rs4646958
rs4646958
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0002395
Disease:
Alzheimer's Disease
0.010 GeneticVariation BEFREE We investigated the association between two polymorphisms of IDE with AD in the Chinese population and found that the T/A genotype of rs4646958 had an important role in AD (adjusted p=0.007, odds ratio [OR]=2.796, 95% confidence interval [CI]=1.330-5.878), under the co-dominant genetic model. 22502914 2012