rs63750264
×
Entrez Id:
351
Gene Symbol:
APP
APP
Abnormal behavior
0.020
GeneticVariation
BEFREE
These transgenic mice showed the same early behavioral disturbances and defects and increased premature death as the APP/London (APP V717I ), APP/Swedish (K670N, M671L), and other APP transgenic mice described previously.
10671319
2000
rs63750264
×
Entrez Id:
351
Gene Symbol:
APP
APP
Abnormal behavior
0.020
GeneticVariation
BEFREE
The London APP mutation (Val717Ile ) associated with early shifting abilities and behavioral changes in two Italian families with early-onset Alzheimer's disease.
20523046
2010
rs63750847
×
Entrez Id:
351
Gene Symbol:
APP
APP
Age-related cognitive decline
0.020
GeneticVariation
BEFREE
A673T , a rare variant in the amyloid-β precursor protein gene, shows a protective potential against Alzheimer's disease (AD) and age-related cognitive decline in an Icelandic population.
24126161
2014
rs63750847
×
Entrez Id:
351
Gene Symbol:
APP
APP
Age-related cognitive decline
0.020
GeneticVariation
BEFREE
This effect closely mimics the phenotype of APP A673T , a recently discovered mutation that protects carriers against AD and age-related cognitive decline .
28115709
2017
rs281865161
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer disease type 1
GA
0.700
CausalMutation
CLINVAR
rs63749964
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer disease type 1
C
0.700
CausalMutation
CLINVAR
rs63750066
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer disease type 1
T
0.700
CausalMutation
CLINVAR
rs63750264
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer disease type 1
A
0.700
CausalMutation
CLINVAR
rs63750264
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer disease type 1
T
0.700
CausalMutation
CLINVAR
rs63750264
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer disease type 1
G
0.700
CausalMutation
CLINVAR
rs63750399
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer disease type 1
C
0.700
CausalMutation
CLINVAR
rs63750643
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer disease type 1
C
0.700
CausalMutation
CLINVAR
rs63750671
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer disease type 1
C
0.700
CausalMutation
CLINVAR
rs63750734
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer disease type 1
T
0.700
CausalMutation
CLINVAR
rs63750973
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer disease type 1
A
0.700
CausalMutation
CLINVAR
rs63751039
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer disease type 1
C
0.700
CausalMutation
CLINVAR
rs63750066
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer Disease, Early Onset
T
0.700
GeneticVariation
CLINVAR
AbetaPP A713T mutation in late onset Alzheimer's disease with cerebrovascular lesions.
19363265
2009
rs63750066
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer Disease, Early Onset
T
0.700
GeneticVariation
CLINVAR
Familial Alzheimer disease associated with A713T mutation in APP.
15488330
2004
rs63750066
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer Disease, Early Onset
T
0.700
GeneticVariation
CLINVAR
APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases.
28350801
2017
rs63750066
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer Disease, Early Onset
T
0.700
GeneticVariation
CLINVAR
Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease.
23224319
2013
rs63750066
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer Disease, Early Onset
T
0.700
GeneticVariation
CLINVAR
Homozygous carriers of APP A713T mutation in an autosomal dominant Alzheimer disease family.
25948718
2015
rs63750066
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer Disease, Early Onset
T
0.700
GeneticVariation
CLINVAR
A family with Alzheimer disease and strokes associated with A713T mutation of the APP gene.
15365148
2004
rs63750066
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer Disease, Early Onset
T
0.700
GeneticVariation
CLINVAR
Predictors for a dementia gene mutation based on gene-panel next-generation sequencing of a large dementia referral series.
30279455
2018
rs63750066
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer Disease, Early Onset
T
0.700
GeneticVariation
CLINVAR
More missense in amyloid gene.
1303275
1992
rs63750066
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer Disease, Early Onset
T
0.700
GeneticVariation
CLINVAR
Modeling the Aggregation Propensity and Toxicity of Amyloid-β Variants.
26402770
2015