KLK3, kallikrein related peptidase 3, 354

N. diseases: 358; N. variants: 19
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs17632542
rs17632542
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0201544
Disease:
Prostate specific antigen measurement
A 0.800 GeneticVariation GWASCAT Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer. 28139693 2017
dbSNP: rs17632542
rs17632542
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0201544
Disease:
Prostate specific antigen measurement
G 0.800 GeneticVariation GWASCAT Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer. 28139693 2017
dbSNP: rs17632542
rs17632542
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0201544
Disease:
Prostate specific antigen measurement
T 0.800 GeneticVariation GWASCAT Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer. 28139693 2017
dbSNP: rs1058205
rs1058205
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0201544
Disease:
Prostate specific antigen measurement
0.800 GeneticVariation GWASCAT Rs16856139 in SLC45A3, the same region as the previous Chinese study, showed an overall significant association with PSA levels (p=2.4×10(-11)) along with rs1058205 in KLK3. 24919509 2014
dbSNP: rs1058205
rs1058205
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0201544
Disease:
Prostate specific antigen measurement
0.800 GeneticVariation GWASDB Rs16856139 in SLC45A3, the same region as the previous Chinese study, showed an overall significant association with PSA levels (p=2.4×10(-11)) along with rs1058205 in KLK3. 24919509 2014
dbSNP: rs1058205
rs1058205
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0201544
Disease:
Prostate specific antigen measurement
0.800 GeneticVariation GWASDB Genetic correction of PSA values using sequence variants associated with PSA levels. 21160077 2010
dbSNP: rs17632542
rs17632542
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0201544
Disease:
Prostate specific antigen measurement
T 0.800 GeneticVariation GWASDB Overall, we detected a genome-wide significant association between PSA levels and single-nucleotide polymorphisms (SNPs) at six loci: 5p15.33 (rs2736098), 10q11 (rs10993994), 10q26 (rs10788160), 12q24 (rs11067228), 17q12 (rs4430796), and 19q13.33 [rs17632542 (KLK3: I179T)], each with P(combined) <3 × 10(-10). 21160077 2010
dbSNP: rs17632542
rs17632542
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0201544
Disease:
Prostate specific antigen measurement
T 0.800 GeneticVariation GWASCAT Overall, we detected a genome-wide significant association between PSA levels and single-nucleotide polymorphisms (SNPs) at six loci: 5p15.33 (rs2736098), 10q11 (rs10993994), 10q26 (rs10788160), 12q24 (rs11067228), 17q12 (rs4430796), and 19q13.33 [rs17632542 (KLK3: I179T)], each with P(combined) <3 × 10(-10). 21160077 2010
dbSNP: rs17632542
rs17632542
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0600139
Disease:
Prostate carcinoma
0.750 GeneticVariation BEFREE Previous research identified four single nucleotide polymorphisms (SNPs) principally associated with circulating PSA levels rather than with prostate cancer risk (TERT rs2736098, FGFR2 rs10788160, TBX3 rs11067228, KLK3 rs17632542). 26431041 2015
dbSNP: rs17632542
rs17632542
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.750 GeneticVariation BEFREE Previous research identified four single nucleotide polymorphisms (SNPs) principally associated with circulating PSA levels rather than with prostate cancer risk (TERT rs2736098, FGFR2 rs10788160, TBX3 rs11067228, KLK3 rs17632542). 26431041 2015
dbSNP: rs17632542
rs17632542
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0600139
Disease:
Prostate carcinoma
T 0.750 GeneticVariation GWASCAT When comparing prostate cancer cases with low PSA controls, alleles at genetic markers rs1512268, rs445114, rs10788160, rs11199874, rs17632542, rs266849, and rs2735839 were associated with an increased risk of prostate cancer, but the effect-estimates were attenuated to the null when using high PSA controls (Pheterogeneity in effect-estimates < 0.04). 24753544 2014
dbSNP: rs17632542
rs17632542
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0600139
Disease:
Prostate carcinoma
T 0.750 GeneticVariation GWASCAT Genome-wide association scan for variants associated with early-onset prostate cancer. 24740154 2014
dbSNP: rs17632542
rs17632542
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0376358
Disease:
Malignant neoplasm of prostate
T 0.750 GeneticVariation GWASDB When comparing prostate cancer cases with low PSA controls, alleles at genetic markers rs1512268, rs445114, rs10788160, rs11199874, rs17632542, rs266849, and rs2735839 were associated with an increased risk of prostate cancer, but the effect-estimates were attenuated to the null when using high PSA controls (Pheterogeneity in effect-estimates < 0.04). 24753544 2014
dbSNP: rs17632542
rs17632542
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.750 GeneticVariation BEFREE The genotypes of 4 single nucleotide polymorphisms previously associated with serum prostate specific antigen levels (rs2736098, rs10788160, rs11067228 and rs17632542) were determined in 964 healthy Caucasian volunteers without prostate cancer. 23246478 2013
dbSNP: rs17632542
rs17632542
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0600139
Disease:
Prostate carcinoma
0.750 GeneticVariation BEFREE The second locus was rs1354774 (P = 1.25 x 10(-12)), near KLK2 at 19q13, which was not associated with tPSA levels, and is separate from the rs17632542 locus at KLK3 that was previously associated with tPSA levels and prostate cancer risk. 23359319 2013
dbSNP: rs17632542
rs17632542
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0600139
Disease:
Prostate carcinoma
0.750 GeneticVariation BEFREE The genotypes of 4 single nucleotide polymorphisms previously associated with serum prostate specific antigen levels (rs2736098, rs10788160, rs11067228 and rs17632542) were determined in 964 healthy Caucasian volunteers without prostate cancer. 23246478 2013
dbSNP: rs17632542
rs17632542
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.750 GeneticVariation BEFREE The second locus was rs1354774 (P = 1.25 x 10(-12)), near KLK2 at 19q13, which was not associated with tPSA levels, and is separate from the rs17632542 locus at KLK3 that was previously associated with tPSA levels and prostate cancer risk. 23359319 2013
dbSNP: rs17632542
rs17632542
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.750 GeneticVariation BEFREE We did not observe a strong association with the KLK3 variant, reported in previous studies to confer risk for prostate cancer (rs2735839; P = 0.20) but did observe three highly correlated SNPs (rs17632542, rs62113212 and rs62113214) associated with prostate cancer [P = 3.41 × 10(-4), per-allele trend odds ratio (OR) = 0.77, 95% CI = 0.67-0.89]. 21318478 2011
dbSNP: rs17632542
rs17632542
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.750 GeneticVariation BEFREE We propose that rs17632542 may directly influence PrCa risk. 21465221 2011
dbSNP: rs17632542
rs17632542
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0600139
Disease:
Prostate carcinoma
0.750 GeneticVariation BEFREE We did not observe a strong association with the KLK3 variant, reported in previous studies to confer risk for prostate cancer (rs2735839; P = 0.20) but did observe three highly correlated SNPs (rs17632542, rs62113212 and rs62113214) associated with prostate cancer [P = 3.41 × 10(-4), per-allele trend odds ratio (OR) = 0.77, 95% CI = 0.67-0.89]. 21318478 2011
dbSNP: rs17632542
rs17632542
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0600139
Disease:
Prostate carcinoma
0.750 GeneticVariation BEFREE We propose that rs17632542 may directly influence PrCa risk. 21465221 2011
dbSNP: rs1058205
rs1058205
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.720 GeneticVariation BEFREE The overall results indicated that polymorphism T>C of rs1058</span>205 was associated with decreased risk of PCa</span> (allele contrast: OR = 0.75, 95% CI = 0.64-0.88, <i>P</i><sub>heterogeneity</sub> < 0.001; homozygote comparison: OR = 0.58, 95% CI = 0.42-0.81, <i>P</i><sub>heterogeneity</sub> < 0.001), particularly in Caucasian population (allele contrast: OR = 0.77, 95% CI = 0.65-0.91, <i>P</i><sub>heterogeneity</sub> < 0.001; homozygote comparison: OR = 0.58, 95% CI = 0.41-0.82, <i>P</i><sub>heterogeneity</sub> < 0.001). 30413614 2018
dbSNP: rs1058205
rs1058205
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.720 GeneticVariation BEFREE The frequency of the TC genotype of rs1058205 in the PCa group was significantly lower than that in the control group (P = 0.049). 28272245 2017
dbSNP: rs1058205
rs1058205
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.720 GeneticVariation GWASDB Multiple newly identified loci associated with prostate cancer susceptibility. 18264097 2008
dbSNP: rs62113212
rs62113212
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0600139
Disease:
Prostate carcinoma
T 0.710 GeneticVariation GWASCAT Two susceptibility loci identified for prostate cancer aggressiveness. 25939597 2015