FAS, Fas cell surface death receptor, 355

N. diseases: 754; N. variants: 47
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0678222
Disease:
Breast Carcinoma 		0.030 GeneticVariation BEFREE Studies on the association between the FAS/FASL polymorphisms (FAS-1377G/A rs2234767, FAS-670A/G rs1800682, and FASL-844C/T rs763110) and breast cancer risk have reported inconsistent results. 24248546 2014
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0678222
Disease:
Breast Carcinoma 		0.030 GeneticVariation BEFREE A statistically significant association was found between Fas rs1800682 and increased breast cancer risk (AG vs AA: OR =1.37, 95% CI =1.06-1.78; AA+AG vs GG: OR =1.32, 95% CI =1.04-1.66), and also it was found that the FasL rs763110 polymorphism may decrease the risk. 27524883 2016
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.030 GeneticVariation BEFREE The present study investigated the association between -1377 G/A (rs2234767) and -670 A/G (rs1800682) polymorphisms in Fas as well as single nucleotide polymorphisms INV2nt -124 A/G (rs5030772) and -844 C/T (rs763110) in FasL in a sample of Iranian patients with breast cancer. 23326385 2013
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.030 GeneticVariation BEFREE A statistically significant association was found between Fas rs1800682 and increased breast cancer risk (AG vs AA: OR =1.37, 95% CI =1.06-1.78; AA+AG vs GG: OR =1.32, 95% CI =1.04-1.66), and also it was found that the FasL rs763110 polymorphism may decrease the risk. 27524883 2016
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.030 GeneticVariation BEFREE Studies on the association between the FAS/FASL polymorphisms (FAS-1377G/A rs2234767, FAS-670A/G rs1800682, and FASL-844C/T rs763110) and breast cancer risk have reported inconsistent results. 24248546 2014
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0678222
Disease:
Breast Carcinoma 		0.030 GeneticVariation BEFREE The present study investigated the association between -1377 G/A (rs2234767) and -670 A/G (rs1800682) polymorphisms in Fas as well as single nucleotide polymorphisms INV2nt -124 A/G (rs5030772) and -844 C/T (rs763110) in FasL in a sample of Iranian patients with breast cancer. 23326385 2013
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0152018
Disease:
Esophageal carcinoma 		0.020 GeneticVariation BEFREE Significant association among the Fas -670 A/G (rs1800682) polymorphism and esophageal cancer, hepatocellular carcinoma, and prostate cancer susceptibility: a meta-analysis. 25085585 2014
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0302592
Disease:
Cervix carcinoma 		0.020 GeneticVariation BEFREE Subgroup analysis by ethnicity suggested that there was no association between CD95 rs1800682 p</span>olymorphism and cervical cancer risk in Asians, Caucasians, and Africans. 24114012 2014
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.020 GeneticVariation BEFREE Fas (rs1800682) and FasL (rs763110) polymorphism were associated with the risk of IVDD and Fas (rs2234767) was correlated to the susceptibility of OA and RA. 29734947 2018
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C4048328
Disease:
cervical cancer 		0.020 GeneticVariation BEFREE However, we did not observe any association between the cervical cancer risk and the rs2234767 and rs1800682 polymorphisms. 27790710 2017
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0302592
Disease:
Cervix carcinoma 		0.020 GeneticVariation BEFREE However, we did not observe any association between the cervical cancer risk and the rs2234767 and rs1800682 polymorphisms. 27790710 2017
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0007847
Disease:
Malignant tumor of cervix 		0.020 GeneticVariation BEFREE Subgroup analysis by ethnicity suggested that there was no association between CD95 rs1800682 p</span>olymorphism and cervical cancer risk in Asians, Caucasians, and Africans. 24114012 2014
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0152018
Disease:
Esophageal carcinoma 		0.020 GeneticVariation BEFREE The case-control study aims to investigate the association of Fas and FasL genetic polymorphisms (Fas-670A/G (rs1800682), Fas-1377G/A (rs2234767) and FasL-844T/C (rs763110)) with esophageal carcinoma susceptibility in a north Chinese population. 26819081 2016
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C4048328
Disease:
cervical cancer 		0.020 GeneticVariation BEFREE Subgroup analysis by ethnicity suggested that there was no association between CD95 rs1800682 p</span>olymorphism and cervical cancer risk in Asians, Caucasians, and Africans. 24114012 2014
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0007847
Disease:
Malignant tumor of cervix 		0.020 GeneticVariation BEFREE However, we did not observe any association between the cervical cancer risk and the rs2234767 and rs1800682 polymorphisms. 27790710 2017
dbSNP: rs1800682
rs1800682
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.020 GeneticVariation BEFREE Meta-analysis showed no association between RA and the FAS rs1800682 G/A polymorphism. 25645050 2015
dbSNP: rs2234767
rs2234767
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0678222
Disease:
Breast Carcinoma 		0.020 GeneticVariation BEFREE Studies on the association between the FAS/FASL polymorphisms (FAS-1377G/A rs2234767, FAS-670A/G rs1800682, and FASL-844C/T rs763110) and breast cancer risk have reported inconsistent results. 24248546 2014
dbSNP: rs2234767
rs2234767
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.020 GeneticVariation BEFREE Studies on the association between the FAS/FASL polymorphisms (FAS-1377G/A rs2234767, FAS-670A/G rs1800682, and FASL-844C/T rs763110) and breast cancer risk have reported inconsistent results. 24248546 2014
dbSNP: rs2234767
rs2234767
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0006826
Disease:
Malignant Neoplasms 		0.020 GeneticVariation BEFREE FAS-1377 G/A (rs2234767) polymorphism and cancer susceptibility: a meta-analysis of 17,858 cases and 24,311 controls. 24014103 2013
dbSNP: rs2234767
rs2234767
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0006826
Disease:
Malignant Neoplasms 		0.020 GeneticVariation BEFREE Further studies on a larger sample size and considering gene-environment interactions should be conducted to confirm the role of FAS polymorphisms, especially rs2234767G/A, in cancer risk. 24568648 2014
dbSNP: rs2234767
rs2234767
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.020 GeneticVariation BEFREE In conclusion, this study demonstrated that Fas rs2234767 G/A and Bcl2 rs17757541 T/C polymorphisms might be associated with an increased risk of RA. 26905515 2016
dbSNP: rs2234767
rs2234767
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0006826
Disease:
Malignant Neoplasms 		0.020 GeneticVariation BEFREE We found that the rs2234767 G-allele was a protective factor for cancer risk (GG vs. AA: OR=0.88, 95% CI=0.79-0.98; GG+GA vs. AA: OR=0.87, 95% CI=0.79-0.96). 24568648 2014
dbSNP: rs2234767
rs2234767
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		0.020 GeneticVariation BEFREE Fas−1377G>A (rs2234767), −670T>C (rs1800682), and FasL−844T>C (rs763110) polymorphisms in 592 AML patients and 858 healthy controls were genotyped and tested for associations between polymorphisms and AML risk. 20438363 2010
dbSNP: rs2234767
rs2234767
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		0.020 GeneticVariation BEFREE We investigated a common G > A polymorphism at position -1377 (rs2234767) in the core promoter of the CD95 cell death receptor gene in 708 subjects with acute myeloid leukemia, including 231 patients with APL. 22084312 2012
dbSNP: rs2234767
rs2234767
Entrez Id: 59;355
Gene Symbol: ACTA2;FAS
ACTA2;FAS
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.020 GeneticVariation BEFREE Fas (rs1800682) and FasL (rs763110) polymorphism were associated with the risk of IVDD and Fas (rs2234767) was correlated to the susceptibility of OA and RA. 29734947 2018