|
rs40401
|
IL3;LOC105379174
|
Asthma
|
|
0.040 |
GeneticVariation |
BEFREE |
This study suggests that IL3 SNP rs40401 is significantly associated with the risk of a</span>sthma in young adult Japanese women and reveals that the combination of ever smoking and having the CC genotype of IL3 SNP rs40401 is significantly positively associated with asthma.
|
24684517 |
2014 |
|
rs40401
|
IL3;LOC105379174
|
Asthma
|
|
0.040 |
GeneticVariation |
BEFREE |
In the initial sample, three SNPs, rs320995 in the cysteinyl leukotriene receptor 1 gene, rs1047266 in the tumour necrosis factor receptor superfamily, member 10b, gene and rs40401 in the interleukin-3 gene, were associated with risk of asthma.
|
18829683 |
2009 |
|
rs40401
|
IL3;LOC105379174
|
Asthma
|
|
0.040 |
GeneticVariation |
BEFREE |
In two large study populations of children, the German part of the International Study of Asthma and Allergy in Childhood (ISAAC II) and the German Multicentre Atopy Study (MAS), 3099 and 824 children, seven polymorphisms previously associated with the development of atopic diseases were genotyped: two in and around the GM-CSF gene (Ile117Thr and T3085G), one in IL-3 (Pro27Ser), in IL-5 (C-746T), and in the IL-5 high affinity receptor chain IL-5R (G-80A) and two in the common receptor chain CSFR2b for IL-3, IL-5, and GM-CSF (Asp312Asn and Glu249Gln).
|
17362254 |
2007 |
|
rs40401
|
IL3;LOC105379174
|
Asthma
|
|
0.040 |
GeneticVariation |
BEFREE |
Genetic association analysis of polymorphisms revealed that one exonic (exon 1), IL3 + 79T > C ( Ser27Pro), showed significant association with the risk of asthma and atopy.
|
15372320 |
2004 |
|
rs40401
|
IL3;LOC105379174
|
Asthma
|
|
0.040 |
GeneticVariation |
BEFREE |
Genetic association analysis of polymorphisms revealed that one exonic (exon 1), IL3 + 79T > C ( Ser27Pro), showed significant association with the risk of asthma and atopy.
|
15372320 |
2004 |
|
rs40401
|
IL3;LOC105379174
|
Graves Disease
|
|
0.020 |
GeneticVariation |
BEFREE |
The results suggested that the polymorphism of IL-3 (rs40401) and IL-5 (rs2069812) were associated with GD and GO susceptibility in Chinese population.
|
20332709 |
2010 |
|
rs40401
|
IL3;LOC105379174
|
Graves Disease
|
|
0.020 |
GeneticVariation |
BEFREE |
We replicated significant association of rs40401 with GD in </span>an independent sample collection of 839 north Han Chinese subjects.
|
19262575 |
2009 |
|
rs40401
|
IL3;LOC105379174
|
Ventricular Fibrillation, Paroxysmal Familial, 1
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our results indicated that the IL-3 rs40401 polymorphism is associated with increased risk of abortion of IVF patients.
|
30893922 |
2019 |
|
rs2073506
|
IL3;LOC105379174
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicated that the IL-3 rs2073506 G/A, IL-3 rs40401 C/T, and IL-13 rs1800925 C/T polymorphisms were not associated with RA.
|
27323078 |
2016 |
|
rs40401
|
IL3;LOC105379174
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicated that the IL-3 rs2073506 G/A, IL-3 rs40401 C/T, and IL-13 rs1800925 C/T polymorphisms were not associated with RA.
|
27323078 |
2016 |
|
rs2073506
|
IL3;LOC105379174
|
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation |
BEFREE |
IL3 rs2073506 G>A polymorphism was associated with an increased risk for ESCC higher TNM stages.
|
23726808 |
2013 |
|
rs2073506
|
IL3;LOC105379174
|
Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
IL3 rs2073506 G>A polymorphism was associated with an increased risk for ESCC higher tumor, nodal, and metastatic (TNM) stages.
|
23726808 |
2013 |
|
rs40401
|
IL3;LOC105379174
|
Allergic rhinitis (disorder)
|
|
0.010 |
GeneticVariation |
BEFREE |
No studies have investigated the relationship between IL3 single nucleotide polymorphism (SNP) rs40401 and allergic rhinitis.
|
23953855 |
2013 |
|
rs40401
|
IL3;LOC105379174
|
Rhinoconjunctivitis
|
|
0.010 |
GeneticVariation |
BEFREE |
This is the first study to show a significant positive association between IL3 SNP rs40401 variant and the risk of rhinoconjunctivitis.
|
23953855 |
2013 |
|
rs40401
|
IL3;LOC105379174
|
Malaria
|
|
0.010 |
GeneticVariation |
BEFREE |
The IL3 genotypes rs40401(CT) and rs40401(TT) were found to exert a protective effect of 25% [incidence rate ratio (IRR) 0.75, P = 4.1 × 10(-5)] and 33% (IRR 0.67, P = 3.2 × 10(-8)), respectively, against malaria attacks.
|
21224257 |
2011 |
|
rs31480
|
IL3;LOC105379174
|
Graves Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Recently, two studies have reported association of single-nucleotide polymorphism (SNP) rs31480 in interleukin 3 (IL-3) and the rs1368408 and SNP75 (-623 approximately -622 AG/-T) SNPs in secretoglobulin family 3a member 2 (SCGB3A2) with GD and suggested that this may account for linkage to the 5q31-33 region in Oriental GD datasets.
|
20210668 |
2010 |
|
rs40401
|
IL3;LOC105379174
|
Thyroid associated opthalmopathies
|
|
0.010 |
GeneticVariation |
BEFREE |
The results suggested that the polymorphism of IL-3 (rs40401) and IL-5 (rs2069812) were associated with GD and GO susceptibility in Chinese population.
|
20332709 |
2010 |