|
rs2069837
|
IL6;IL6-AS1
|
Hypertensive disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Hypertension significantly modified the association between rs2069837 polymorphisms and the risk of LOAD (pinteraction = 0.03).
|
22272811 |
2012 |
|
rs1800796
|
IL6;STEAP1B;IL6-AS1
|
Tuberculosis
|
|
0.020 |
GeneticVariation |
BEFREE |
rs1800796 of the IL6 gene is associated with increased risk for anti-tuberculosis drug-induced hepatotoxicity in Chinese Han children.
|
30029918 |
2018 |
|
rs1800796
|
IL6;STEAP1B;IL6-AS1
|
Drug-Induced Liver Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
rs1800796 of the IL6 gene is associated with increased risk for anti-tuberculosis drug-induced hepatotoxicity in Chinese Han children.
|
30029918 |
2018 |
|
rs2069837
|
IL6;IL6-AS1
|
Longevity
|
A |
0.700 |
GeneticVariation |
GWASCAT |
A meta-analysis of genome-wide association studies identifies multiple longevity genes.
|
31413261 |
2019 |
|
rs1800795
|
IL6;STEAP1B;IL6-AS1
|
Alzheimer's Disease
|
|
0.720 |
GeneticVariation |
GWASCAT |
A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin.
|
26545630 |
2016 |
|
rs1800797
|
IL6;STEAP1B;IL6-AS1
|
cervical cancer
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association of CxCa with various polymorphisms was observed: rs1800797 in the IL-6 gene (odds ratio [OR] = 0.88, 95% confidence intervals [CI]: 0.79-0.99); rs1041981 in the LTA gene (OR = 0.87, 95% CI: 0.78-0.98), and rs9344 in the CCND1 gene (OR = 1.14, 95% CI: 1.02-1.27), for those individuals carrying the rare allele.
|
19585495 |
2009 |
|
rs1800797
|
IL6;STEAP1B;IL6-AS1
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association of CxCa with various polymorphisms was observed: rs1800797 in the IL-6 gene (odds ratio [OR] = 0.88, 95% confidence intervals [CI]: 0.79-0.99); rs1041981 in the LTA gene (OR = 0.87, 95% CI: 0.78-0.98), and rs9344 in the CCND1 gene (OR = 1.14, 95% CI: 1.02-1.27), for those individuals carrying the rare allele.
|
19585495 |
2009 |
|
rs1800797
|
IL6;STEAP1B;IL6-AS1
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association of CxCa with various polymorphisms was observed: rs1800797 in the IL-6 gene (odds ratio [OR] = 0.88, 95% confidence intervals [CI]: 0.79-0.99); rs1041981 in the LTA gene (OR = 0.87, 95% CI: 0.78-0.98), and rs9344 in the CCND1 gene (OR = 1.14, 95% CI: 1.02-1.27), for those individuals carrying the rare allele.
|
19585495 |
2009 |
|
rs1800795
|
IL6;STEAP1B;IL6-AS1
|
Cerebral Palsy
|
|
0.020 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (SNP), rs1800795, in the promoter region of the interleukin-6 (IL6) gene has been implicated in the pathogenesis of CP by mediating IL-6 protein levels in amniotic fluid and cord plasma and within brain lesions.
|
24314052 |
2013 |
|
rs1800795
|
IL6;STEAP1B;IL6-AS1
|
Lesion of brain
|
|
0.010 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (SNP), rs1800795, in the promoter region of the interleukin-6 (IL6) gene has been implicated in the pathogenesis of CP by mediating IL-6 protein levels in amniotic fluid and cord plasma and within brain lesions.
|
24314052 |
2013 |
|
rs1800797
|
IL6;STEAP1B;IL6-AS1
|
Allergic rhinitis (disorder)
|
|
0.010 |
GeneticVariation |
BEFREE |
AA genotype in rs1800797 of IL-6 was associated with the increased risk of developing AR.
|
24974143 |
2014 |
|
rs777906302
|
IL6;IL6-AS1
|
Urinary tract infection
|
|
0.010 |
GeneticVariation |
BEFREE |
Abbreviations: 3-PEHPC: 3-pyridinyl ethylidene hydroxyl phosphonocarboxylate; ATG: autophagy; ATG16L1: autophagy related 16 like 1; BECs: bladder epithelial cells; dpi: days post infection; hpi: hours post infection; IF: immunofluorescence; IL1B: interleukin 1 beta; IL6: interleukin 6; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MVB: multivesicular bodies; T300A: Thr300Ala; TNF: tumor necrosis factor; QIR(s): quiescent intracellular reservoir(s); siRNA: short interfering RNA; UPEC: uropathogenic Escherichia coli; UTI(s): urinary tract infection(s); TEM: transmission electron microscopy; WT: wild type.
|
30335568 |
2019 |
|
rs777906302
|
IL6;IL6-AS1
|
Recurrent urinary tract infection
|
|
0.010 |
GeneticVariation |
BEFREE |
Abbreviations: 3-PEHPC: 3-pyridinyl ethylidene hydroxyl phosphonocarboxylate; ATG: autophagy; ATG16L1: autophagy related 16 like 1; BECs: bladder epithelial cells; dpi: days post infection; hpi: hours post infection; IF: immunofluorescence; IL1B: interleukin 1 beta; IL6: interleukin 6; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MVB: multivesicular bodies; T300A: Thr300Ala; TNF: tumor necrosis factor; QIR(s): quiescent intracellular reservoir(s); siRNA: short interfering RNA; UPEC: uropathogenic Escherichia coli; UTI(s): urinary tract infection(s); TEM: transmission electron microscopy; WT: wild type.
|
30335568 |
2019 |
|
rs1800797
|
IL6;STEAP1B;IL6-AS1
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer.
|
29552316 |
2018 |
|
rs1800797
|
IL6;STEAP1B;IL6-AS1
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation |
BEFREE |
Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer.
|
29552316 |
2018 |
|
rs1800797
|
IL6;STEAP1B;IL6-AS1
|
Adult Diffuse Large B-Cell Lymphoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer.
|
29552316 |
2018 |
|
rs1800797
|
IL6;STEAP1B;IL6-AS1
|
Diffuse Large B-Cell Lymphoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer.
|
29552316 |
2018 |
|
rs2069837
|
IL6;IL6-AS1
|
Papillary thyroid carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, rs2069837 variant elevated the PTC risk based on dominant model (p = 0.041).
|
31288714 |
2019 |
|
rs1800795
|
IL6;STEAP1B;IL6-AS1
|
Coronary Artery Disease
|
|
0.040 |
GeneticVariation |
BEFREE |
Additionally, we found that carriers of the <i>C</i> allele of 174<i>G>C</i> (rs1800795) polymorphism have an increase in the risk of coronary artery disease under the hereditary models assessed in the study.
|
31338006 |
2019 |
|
rs1800795
|
IL6;STEAP1B;IL6-AS1
|
Coronary heart disease
|
|
0.020 |
GeneticVariation |
BEFREE |
Additionally, we found that carriers of the <i>C</i> allele of 174<i>G>C</i> (rs1800795) polymorphism have an increase in the risk of coronary artery disease under the hereditary models assessed in the study.
|
31338006 |
2019 |
|
rs1800795
|
IL6;STEAP1B;IL6-AS1
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, we found that carriers of the <i>C</i> allele of 174<i>G>C</i> (rs1800795) polymorphism have an increase in the risk of coronary artery disease under the hereditary models assessed in the study.
|
31338006 |
2019 |
|
rs1800796
|
IL6;STEAP1B;IL6-AS1
|
Osteoporosis
|
|
0.040 |
GeneticVariation |
BEFREE |
After adjusting for age, the IL6 -634G > C (rs1800796) allele showed association with osteoporosis (odds ratio (OR) for CC + CG = 2.51, p = 0.0047)), independent of statin use or smoking status.
|
19506792 |
2010 |
|
rs1800795
|
IL6;STEAP1B;IL6-AS1
|
Post-Traumatic Stress Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
Although our nominally significant results did not withstand correction for multiple tests they may support a relevance of the COMT (Val158Met) and IL6 rs1800795 polymorphism for aspects of PTSD in war traumatized individuals.
|
31291232 |
2019 |
|
rs2069832
|
IL6;IL6-AS1
|
Systemic Inflammatory Response Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
Among Caucasian subjects with SIRS (n = 750), we identified a nominal association between rs2069832 in IL6 and ALI susceptibility (OR(adj) 1.61; 95% confidence interval [CI], 1.04-2.48, P = 0.03).
|
23251429 |
2012 |
|
rs1800797
|
IL6;STEAP1B;IL6-AS1
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation |
BEFREE |
Among postmenopausal women not recently exposed to hormones, the AG/GG genotypes of rs1800797 (-596A>G) and the GC/CC genotypes of rs1800795 (-174G>C) significantly reduced risk of breast cancer among non-Hispanic white women [odds ratio (OR), 0.69; 95% confidence interval (95% CI), 0.48-1.00 and OR, 0.68; 95% CI, 0.47-0.99, respectively] and Hispanic/Native American women (OR, 0.48; 95% CI, 0.28-0.83 and OR, 0.44; 95% CI, 0.26-0.99, respectively).
|
17416766 |
2007 |