IL10, interleukin 10, 3586

N. diseases: 1679; N. variants: 21
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3024493
rs3024493
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.720 GeneticVariation BEFREE Significant interactions were observed between <i>CD40</i> variant rs48100485 and VCA IgG levels and <i>IL10</i> variant rs3024493 and VCA IgA levels in transitioning to SLE. 31217170 2019
dbSNP: rs3024493
rs3024493
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
T 0.720 GeneticVariation GWASCAT Transancestral mapping and genetic load in systemic lupus erythematosus. 28714469 2017
dbSNP: rs3024493
rs3024493
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
A 0.720 GeneticVariation GWASCAT Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. 26502338 2015
dbSNP: rs3024493
rs3024493
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.720 GeneticVariation BEFREE SNP imputation conducted in EA dataset identified three additional SLE-associated SNPs tagged by rs3024505 (rs3122605, rs3024493 and rs3024495 located at 9.2 kb upstream, intron 3 and 4 of IL10, respectively), and SLE-risk alleles of these SNPs were dose-dependently associated with elevated levels of IL10 mRNA in PBMCs and circulating IL-10 protein in SLE patients and controls. 24130510 2013
dbSNP: rs1800896
rs1800896
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.030 GeneticVariation BEFREE Interleukin 10 gene promoter polymorphisms (rs1800896, rs1800871 and rs1800872) and haplotypes are associated with the activity of systemic lupus erythematosus and IL10 levels in an Iranian population. 30430731 2019
dbSNP: rs1800896
rs1800896
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.030 GeneticVariation BEFREE There was no association between rs1800896 and SLE, although a tendency for genetic predisposition to SLE was observed for the IL10 -1082 GG genotype under the recessive genetic model (OR = 1.454). 29298134 2018
dbSNP: rs1800896
rs1800896
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.030 GeneticVariation BEFREE In addition, we found IL-10 rs1800896 GG homozygote might be associated with increased susceptibility to SLE (GG vs AA, P = 4.65 × 10<sup>-3</sup>, OR 1.539, 95% CI 1.142-2.072). 30171347 2018
dbSNP: rs1800871
rs1800871
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.010 GeneticVariation BEFREE Interleukin 10 gene promoter polymorphisms (rs1800896, rs1800871 and rs1800872) and haplotypes are associated with the activity of systemic lupus erythematosus and IL10 levels in an Iranian population. 30430731 2019
dbSNP: rs1800872
rs1800872
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.010 GeneticVariation BEFREE Interleukin 10 gene promoter polymorphisms (rs1800896, rs1800871 and rs1800872) and haplotypes are associated with the activity of systemic lupus erythematosus and IL10 levels in an Iranian population. 30430731 2019
dbSNP: rs1518110
rs1518110
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.010 GeneticVariation BEFREE Meanwhile, significant difference in genotype frequency at rs1518110 and rs1518111 were found in patients with and without lupus headache (P=0.025, P=0.038, respectively). 29199038 2018
dbSNP: rs1518111
rs1518111
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.010 GeneticVariation BEFREE Meanwhile, significant difference in genotype frequency at rs1518110 and rs1518111 were found in patients with and without lupus headache (P=0.025, P=0.038, respectively). 29199038 2018
dbSNP: rs3024498
rs3024498
Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.010 GeneticVariation BEFREE And, there was significant difference in allele frequency at rs3024498 between SLE patients with and without anti-double-stranded DNA (P=0.032). 29199038 2018
dbSNP: rs3024495
rs3024495
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.010 GeneticVariation BEFREE SNP imputation conducted in EA dataset identified three additional SLE-associated SNPs tagged by rs3024505 (rs3122605, rs3024493 and rs3024495 located at 9.2 kb upstream, intron 3 and 4 of IL10, respectively), and SLE-risk alleles of these SNPs were dose-dependently associated with elevated levels of IL10 mRNA in PBMCs and circulating IL-10 protein in SLE patients and controls. 24130510 2013