IL10, interleukin 10, 3586

N. diseases: 1679; N. variants: 21
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800871
rs1800871
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0004943
Disease:
Behcet Syndrome
0.830 GeneticVariation BEFREE Our findings not only confirmed the association of IL10/rs1800871 and IL23R-IL12RB2/rs924080 with BD but also identified 2 susceptibility single nucleotide polymorphisms in IL10 and IL23R-IL12RB2 (rs3024490 and rs12141431) with BD in Han Chinese. 27464962 2017
dbSNP: rs1518111
rs1518111
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0004943
Disease:
Behcet Syndrome
0.830 GeneticVariation BEFREE Interestingly, we have found, majority of the tribal populations have low frequency of VL ('A' of rs3024498); and high frequency of leprosy ('T' of rs1554286), and Behcet's ('A' of rs1518111) associated alleles, whereas these were vice versa in castes. 25941808 2015
dbSNP: rs1800871
rs1800871
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0004943
Disease:
Behcet Syndrome
0.830 GeneticVariation BEFREE Compared to the controls, an increased frequency of the rs1800871 T allele was observed in BD patients with extraocular findings, including genital ulcers, skin lesions, and a positive pathergy test. 26015771 2015
dbSNP: rs1518111
rs1518111
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0004943
Disease:
Behcet Syndrome
0.830 GeneticVariation BEFREE Similarly, rs1518111, which showed strong linkage disequilibrium (r(2)=1) with allele rs1800871, was also associated with BD (pc=0.026). 24269690 2014
dbSNP: rs1800871
rs1800871
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0004943
Disease:
Behcet Syndrome
0.830 GeneticVariation BEFREE Similarly, rs1518111, which showed strong</span> linkage disequilibrium (r(2)=1) with allele rs1800871, was also associated with BD (pc=0.026). 24269690 2014
dbSNP: rs1800871
rs1800871
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0004943
Disease:
Behcet Syndrome
0.830 GeneticVariation GWASDB Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. 23291587 2013
dbSNP: rs1518111
rs1518111
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0004943
Disease:
Behcet Syndrome
0.830 GeneticVariation BEFREE In IL10, rs1518111 was nominally associated with BD before and after adjustment for population stratification (odds ratio [OR] for T allele 1.20, 95% confidence interval [95% CI] 1.02-1.40, unadjusted P [P(unadj) ] = 2.53 × 10(-2) ; adjusted P [P(adj) ] = 1.43 × 10(-2) ), and rs1554286 demonstrated a trend toward association (P(unadj) = 6.14 × 10(-2) ; P(adj) = 3.21 × 10(-2) ). 22378604 2012
dbSNP: rs1518111
rs1518111
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0004943
Disease:
Behcet Syndrome
0.830 GeneticVariation GWASDB Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. 20622878 2010
dbSNP: rs1518111
rs1518111
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0004943
Disease:
Behcet Syndrome
0.830 GeneticVariation GWASCAT Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. 20622878 2010
dbSNP: rs1800871
rs1800871
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0004943
Disease:
Behcet Syndrome
T 0.830 GeneticVariation GWASDB Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci. 20622879 2010
dbSNP: rs1800871
rs1800871
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0004943
Disease:
Behcet Syndrome
T 0.830 GeneticVariation GWASCAT Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci. 20622879 2010
dbSNP: rs3024493
rs3024493
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0009324
Disease:
Ulcerative Colitis
0.800 GeneticVariation GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
dbSNP: rs3024493
rs3024493
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0009324
Disease:
Ulcerative Colitis
T 0.800 GeneticVariation GWASCAT Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). 20228798 2010
dbSNP: rs3024493
rs3024493
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0009324
Disease:
Ulcerative Colitis
T 0.800 GeneticVariation GWASDB Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). 20228798 2010
dbSNP: rs3024493
rs3024493
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0009324
Disease:
Ulcerative Colitis
0.800 GeneticVariation GWASCAT Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. 19915572 2009
dbSNP: rs3024493
rs3024493
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0009324
Disease:
Ulcerative Colitis
0.800 GeneticVariation GWASDB Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. 19915572 2009
dbSNP: rs3024493
rs3024493
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.720 GeneticVariation BEFREE Significant interactions were observed between <i>CD40</i> variant rs48100485 and VCA IgG levels and <i>IL10</i> variant rs3024493 and VCA IgA levels in transitioning to SLE. 31217170 2019
dbSNP: rs3024493
rs3024493
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
T 0.720 GeneticVariation GWASCAT Transancestral mapping and genetic load in systemic lupus erythematosus. 28714469 2017
dbSNP: rs3024493
rs3024493
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
A 0.720 GeneticVariation GWASCAT Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. 26502338 2015
dbSNP: rs3024493
rs3024493
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.720 GeneticVariation BEFREE SNP imputation conducted in EA dataset identified three additional SLE-associated SNPs tagged by rs3024505 (rs3122605, rs3024493 and rs3024495 located at 9.2 kb upstream, intron 3 and 4 of IL10, respectively), and SLE-risk alleles of these SNPs were dose-dependently associated with elevated levels of IL10 mRNA in PBMCs and circulating IL-10 protein in SLE patients and controls. 24130510 2013
dbSNP: rs3024490
rs3024490
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0004943
Disease:
Behcet Syndrome
0.710 GeneticVariation BEFREE Our findings not only confirmed the association of IL10/rs1800871 and IL23R-IL12RB2/rs924080 with BD but also identified 2 susceptibility single nucleotide polymorphisms in IL10 and IL23R-IL12RB2 (rs3024490 and rs12141431) with BD in Han Chinese. 27464962 2017
dbSNP: rs3024490
rs3024490
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0004943
Disease:
Behcet Syndrome
0.710 GeneticVariation GWASDB Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. 23291587 2013
dbSNP: rs1800871
rs1800871
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0149745
Disease:
Oral Ulcer
G 0.700 GeneticVariation GWASCAT Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci. 30837455 2019
dbSNP: rs3024493
rs3024493
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0033860
Disease:
Psoriasis
0.700 GeneticVariation GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
dbSNP: rs3024493
rs3024493
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0010346
Disease:
Crohn Disease
0.700 GeneticVariation GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016