IL18, interleukin 18, 3606

N. diseases: 750; N. variants: 18
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1834481
rs1834481
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C2697766
Disease:
Interleukin 18 Measurement
G 0.800 GeneticVariation GWASCAT Forward selection analysis indicated that SNPs rs2115763 and rs1834481 were independently associated with IL-18 levels (P=0.0002 and 0.0006, respectively). 20150558 2010
dbSNP: rs1834481
rs1834481
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C2697766
Disease:
Interleukin 18 Measurement
G 0.800 GeneticVariation GWASDB Forward selection analysis indicated that SNPs rs2115763 and rs1834481 were independently associated with IL-18 levels (P=0.0002 and 0.0006, respectively). 20150558 2010
dbSNP: rs1834481
rs1834481
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0201657
Disease:
C-reactive protein measurement
C 0.700 GeneticVariation GWASDB Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults. 24182552 2014
dbSNP: rs5744256
rs5744256
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0201657
Disease:
C-reactive protein measurement
C 0.700 GeneticVariation GWASDB Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults. 24182552 2014
dbSNP: rs1946518
rs1946518
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0041296
Disease:
Tuberculosis
0.050 GeneticVariation BEFREE Collectively, this meta-analysis proved that IL-6 rs1800795, IL-18 rs1946518 and IL-18 rs187238 polymorphisms may confer susceptibility to TB, especially for Asians. 31676365 2020
dbSNP: rs1946518
rs1946518
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0041296
Disease:
Tuberculosis
0.050 GeneticVariation BEFREE A case-control study was performed to investigate whether two promoter polymorphisms of the IL-18 gene at positions -137G/A (rs187238) and -607A/C (rs1946518) affect the serum level of IL-18 and might be associated with genetic susceptibility to tuberculosis (TB) in the Polish population. 31301271 2019
dbSNP: rs549908
rs549908
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0004096
Disease:
Asthma
0.050 GeneticVariation BEFREE Growing evidence indicated conflicting results that Interleukin-18 (IL-18) promoter polymorphisms rs1946518 (A-607C), rs187238 (G-137C) and rs549908 (A-105C) were associated with asthma risk. 31522432 2019
dbSNP: rs1946518
rs1946518
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0041296
Disease:
Tuberculosis
0.050 GeneticVariation BEFREE Numerous studies have evaluated the association between interleukin-18 (IL-18) promoter gene -607C/ A (rs1946518) polymorphism and tuberculosis (TB) risk. 24033965 2013
dbSNP: rs1946518
rs1946518
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0041296
Disease:
Tuberculosis
0.050 GeneticVariation BEFREE Susceptibility to TB-IRD associated with carriage of TNFA-1031*T (rs1799964; P=0.05) and SLC11A1 D543N*G (rs17235409; P=0.04) in Cambodian patients and carriage of IL18-607*G (rs1946518; P=0.02) and VDR FokI (F/f)*T (rs10735810; P=0.05) in Indian patients. 23594560 2013
dbSNP: rs1946518
rs1946518
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0041296
Disease:
Tuberculosis
0.050 GeneticVariation BEFREE It also revealed that allele A of rs1946518 confers a 1.47-fold increased risk of developing tuberculosis (TB) (P = 0.0001, OR [95%CI] = 1.47 [1.21-1.78]), and that the C allele of rs5744247 confers a 0.77-fold decreased risk of disease (P = 0.01, R [95%CI] = 0.77 [0.632-0.937]). 21395662 2011
dbSNP: rs549908
rs549908
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0004096
Disease:
Asthma
0.050 GeneticVariation BEFREE An IL-18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma, rheumatoid, and systemic lupus erythematosus. 19288449 2009
dbSNP: rs549908
rs549908
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0004096
Disease:
Asthma
0.050 GeneticVariation BEFREE An IL-18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma and rheumatoid arthritis. 18250135 2008
dbSNP: rs549908
rs549908
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0004096
Disease:
Asthma
0.050 GeneticVariation BEFREE We previously demonstrated a significant association between IL-18 gene polymorphism 105A/C and asthma. 16516851 2006
dbSNP: rs549908
rs549908
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0004096
Disease:
Asthma
0.050 GeneticVariation BEFREE The 105A/C polymorphism of the IL-18 gene may be associated with the pathogenesis of asthma. 12911784 2003
dbSNP: rs187238
rs187238
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0010346
Disease:
Crohn Disease
0.030 GeneticVariation BEFREE The results demonstrated that IL‑18 (rs187238, ‑137G/C) increased the incidence rate of colon cancer in patients, while IL‑18 (rs187238, ‑137G/C) decreased the incidence rate of ulcerative colitis or Crohn's disease in patients. 31017261 2019
dbSNP: rs1946518
rs1946518
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C2239176
Disease:
Liver carcinoma
0.030 GeneticVariation BEFREE Collectively, this meta-analysis proved that VDR rs7975232, VDR rs2228570, VEGF rs699947, VEGF rs3025039, IL-18 rs1946518, and MBL rs7096206 polymorphisms may confer susceptibility to HCC in certain populations. 31830994 2019
dbSNP: rs549908
rs549908
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.030 GeneticVariation BEFREE We therefore investigated for the influence of interleukin-18 (-1297T/C, -607A/C, -137G/C; + 105A/C) polymorphisms on genetic susceptibility and clinical expression of the disease in Indian systemic lupus erythematosus patients. 30857465 2019
dbSNP: rs1946518
rs1946518
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C2239176
Disease:
Liver carcinoma
0.030 GeneticVariation BEFREE However, we failed to uncover any significant association between other polymorphisms in genes of IL-12 signaling pathway and HCC risk, including <i>IL18</i>-rs1946518 and -rs187238, <i>IFN-γ</i>-rs2430561, <i>IL12A</i>-rs568408, <i>IL12B</i>-rs3212227 and <i>STAT4</i>-rs7574865. 30310516 2018
dbSNP: rs187238
rs187238
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0011854
Disease:
Diabetes Mellitus, Insulin-Dependent
0.030 GeneticVariation BEFREE The polymorphisms rs187238 and rs5435 were not associated with T1D in the studied population. 28973736 2017
dbSNP: rs1946518
rs1946518
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C2239176
Disease:
Liver carcinoma
0.030 GeneticVariation BEFREE Genetic polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 promoter may not be associated with development of hepatocellular carcinoma. 28000712 2016
dbSNP: rs187238
rs187238
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0010346
Disease:
Crohn Disease
0.030 GeneticVariation BEFREE This meta-analysis indicated that the IL-18 rs1946518 A>C, rs187238 G>C and rs360718 A>C polymorphisms may contribute to susceptibility to CD, especially among Asians and Africans. 26229413 2015
dbSNP: rs187238
rs187238
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0010346
Disease:
Crohn Disease
0.030 GeneticVariation BEFREE The polymorphisms TLR5 (rs5744174) and IL12B (rs6887695) were associated with risk of CD, and TLR1 (rs4833095) and IL18 (rs187238) were associated with risk of both CD and UC (p<0.05). 26698117 2015
dbSNP: rs187238
rs187238
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0011854
Disease:
Diabetes Mellitus, Insulin-Dependent
0.030 GeneticVariation BEFREE The aim of this study was to determine whether the functional interleukin-18 (IL-18) promoter -607 C/A (rs1946518) and -137 G/C (rs187238) polymorphisms are associated with susceptibility to type 1 diabetes (TID). 26116895 2015
dbSNP: rs187238
rs187238
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.030 GeneticVariation BEFREE The third SNP, rs187238, was not significantly associated with SLE in any of the populations examined. 26026656 2015
dbSNP: rs1946518
rs1946518
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.030 GeneticVariation BEFREE In summary, this study identified a significant association between SLE and two SNPs within the IL-18 gene promoter region (rs360719 and rs1946518</span>) in a European population, but not in populations of Asian origin. 26026656 2015