rs137852783
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
Diabetes Mellitus, Non-Insulin-Dependent
0.760
GeneticVariation
BEFREE
The T-allele of the SNP rs12255372 of TCF7L2 (OR = 2.70, 95% CI = 1.12-6.49, P = 0.027 ) and the A-allele of PDX-1 D76N (OR = 3.93, 95% CI = 1.60-7.68, P = 0.002) were significantly associated with an increased risk of T2DM .
26058934
2015
rs137852783
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
Diabetes Mellitus, Non-Insulin-Dependent
0.760
GeneticVariation
BEFREE
So far, this is the l argest association study regardi ng the effect of D76N IPF1 on T2D .
17592437
2007
rs137852783
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
Diabetes Mellitus, Non-Insulin-Dependent
0.760
GeneticVariation
BEFREE
The D76N variant of PDX1 does not significantly alter insulin secretion or act as a high-risk susceptibility allele for late-onset type 2 diabetes as proposed previously, although we cannot exclude a minor role in increasing risk of diabetes.
15277425
2004
rs137852783
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
Diabetes Mellitus, Non-Insulin-Dependent
0.760
GeneticVariation
BEFREE
We genotyped U.S. Caucasians with (n = 217) and without (n = 176) Type 2 diabetes to determine if three previously identified variants (Cys18Arg, Asp76Asn , Arg197His) in the IPF-1 gene play a role in the development of Type 2 diabetes .
11914043
2002
rs137852783
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
Diabetes Mellitus, Non-Insulin-Dependent
0.760
GeneticVariation
BEFREE
The D76N variant was found in one MODY3 family (S315fsinsA of HNF1alpha) and also in two families with late-onset Type II diabetes .
11270685
2001
rs137852783
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
Diabetes Mellitus, Non-Insulin-Dependent
0.760
GeneticVariation
BEFREE
In the patients with late-onset type 2 diabetes we identified a noncoding G insertion/deletion polymorphism at nucleotide -108, a silent G54G, and a rare missense D76N variant.
10720084
2000
rs137852783
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
Diabetes Mellitus, Non-Insulin-Dependent
A
0.760
SusceptibilityMutation
CLINVAR
rs137852786
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
Diabetes Mellitus, Non-Insulin-Dependent
0.720
GeneticVariation
BEFREE
We genotyped U.S. Caucasians with (n = 217) and without (n = 176) Type 2 diabetes to determine if three previously identified variants (Cys18Arg, Asp76Asn, Arg197His ) in the IPF-1 gene play a role in the development of Type 2 diabetes .
11914043
2002
rs137852786
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
Diabetes Mellitus, Non-Insulin-Dependent
0.720
GeneticVariation
BEFREE
Three novel IPF-1 missense mutations (C18R, D76N, and R197H ) were identified in patients with type 2 diabetes .
10545530
1999
rs137852786
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
Diabetes Mellitus, Non-Insulin-Dependent
A
0.720
SusceptibilityMutation
CLINVAR
rs137852785
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
Diabetes Mellitus, Non-Insulin-Dependent
0.710
GeneticVariation
BEFREE
We genotyped U.S. Caucasians with (n = 217) and without (n = 176) Type 2 diabetes to determine if three previously identified variants (Cys18Arg , Asp76Asn, Arg197His) in the IPF-1 gene play a role in the development of Type 2 diabetes.
11914043
2002
rs137852785
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
Diabetes Mellitus, Non-Insulin-Dependent
C
0.710
SusceptibilityMutation
CLINVAR
rs9581943
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
Pancreatic carcinoma
A
0.700
GeneticVariation
GWASCAT
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
29422604
2018
rs7981781
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
Fasting blood glucose measurement
A
0.700
GeneticVariation
GWASCAT
Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.
28270201
2017
rs9581943
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
Pancreatic carcinoma
0.700
GeneticVariation
GWASCAT
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
26098869
2015
rs9581943
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
Pancreatic carcinoma
A
0.700
GeneticVariation
GWASCAT
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
25086665
2014
rs7993724
×
Entrez Id:
3651;100861550
Gene Symbol:
PDX1;PLUT
PDX1;PLUT
High density lipoprotein measurement
0.700
GeneticVariation
GWASDB
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
23063622
2012
rs7993724
×
Entrez Id:
3651;100861550
Gene Symbol:
PDX1;PLUT
PDX1;PLUT
Serum total cholesterol measurement
0.700
GeneticVariation
GWASDB
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
23063622
2012
rs7993724
×
Entrez Id:
3651;100861550
Gene Symbol:
PDX1;PLUT
PDX1;PLUT
Low density lipoprotein cholesterol measurement
0.700
GeneticVariation
GWASDB
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
23063622
2012
rs7993724
×
Entrez Id:
3651;100861550
Gene Symbol:
PDX1;PLUT
PDX1;PLUT
Serum LDL cholesterol measurement
0.700
GeneticVariation
GWASDB
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
23063622
2012
rs7993724
×
Entrez Id:
3651;100861550
Gene Symbol:
PDX1;PLUT
PDX1;PLUT
Triglycerides measurement
0.700
GeneticVariation
GWASDB
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
23063622
2012
rs7993724
×
Entrez Id:
3651;100861550
Gene Symbol:
PDX1;PLUT
PDX1;PLUT
Serum HDL cholesterol measurement
0.700
GeneticVariation
GWASDB
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
23063622
2012
rs387906777
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
DIABETES MELLITUS, PERMANENT NEONATAL
G
0.700
CausalMutation
CLINVAR
A novel hypomorphic PDX1 mutation responsible for permanent neonatal diabetes with subclinical exocrine deficiency.
20009086
2010
rs387906777
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
DIABETES MELLITUS, PERMANENT NEONATAL
G
0.700
CausalMutation
CLINVAR
Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1.
12970316
2003
rs137852783
×
Entrez Id:
3651
Gene Symbol:
PDX1
PDX1
Maturity onset diabetes mellitus in young
A
0.700
GeneticVariation
CLINVAR