PDX1, pancreatic and duodenal homeobox 1, 3651

N. diseases: 185; N. variants: 22
Disease: Diabetes ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs137852784
rs137852784
Entrez Id: 3651
Gene Symbol: PDX1
PDX1
CUI: C0011847
Disease:
Diabetes 		0.020 GeneticVariation BEFREE Three variants (C18R, Q59L and D76N) were screened by PCR-RFLP in a group of 296 unrelated French late-onset type 2 diabetic subjects consecutively recruited in a diabetes department of a university hospital, regardless of family history of diabetes. 11022198 2000
dbSNP: rs137852784
rs137852784
Entrez Id: 3651
Gene Symbol: PDX1
PDX1
CUI: C0011847
Disease:
Diabetes 		0.020 GeneticVariation BEFREE The lower penetrance D76N and Q59L mutations were more prevalent and were associated with a relative risk of 12.6 for diabetes and with decreased glucose-stimulated insulin-secretion in nondiabetic subjects. 10545531 1999