Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1801276
rs1801276
Entrez Id: 3667
Gene Symbol: IRS1
IRS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.060 GeneticVariation BEFREE The IRS1 gene variants Gly972Arg and Ala513Pro are not associated with type 2 diabetes in this south Indian population. 21612394 2011
dbSNP: rs1801276
rs1801276
Entrez Id: 3667
Gene Symbol: IRS1
IRS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.060 GeneticVariation BEFREE Insulin resistance and glucose dysmetabolism in polycystic ovary syndrome (PCOS) are related with the polymorphisms in the genes encoding the insulin receptor substrate (IRS) proteins, especially Gly972Arg/Ala513Pro polymorphism being reported to be associated with type-2 diabetes and PCOS. 16603055 2006
dbSNP: rs1801276
rs1801276
Entrez Id: 3667
Gene Symbol: IRS1
IRS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.060 GeneticVariation BEFREE Five variant sequences of IRS-1 were identified with the NIDDM subjects; 2 silent polymorphisms at codons 235 (GGG to GGA) and 893 (CCG to CCC): 2 non-conservative mutations (Ala513Pro; Gly972Arg) and a codon deletion (Ser681-7 to Ser681-6). 8641117 1996
dbSNP: rs1801276
rs1801276
Entrez Id: 3667
Gene Symbol: IRS1
IRS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.060 GeneticVariation BEFREE Two mutations of the IRS-1 gene (Gly(972)Arg and Ala(513)Pro) have been described, although their roles in the development of insulin resistance and non-insulin-dependent diabetes mellitus (NIDDM) remain controversial. 9162610 1996
dbSNP: rs1801276
rs1801276
Entrez Id: 3667
Gene Symbol: IRS1
IRS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.060 GeneticVariation BEFREE The purpose of this study was to examine the role of the IRS-1 missense mutations at codons 972 (glycine to arginine) and 513 (alanine to proline) in two diverse populations from South India and Finland at high risk for NIDDM. 7796990 1995
dbSNP: rs1801276
rs1801276
Entrez Id: 3667
Gene Symbol: IRS1
IRS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.060 GeneticVariation BEFREE We studied a simple tandem repeat DNA polymorphism in the glycogen synthase gene and polymorphisms at codon 513 (Ala-->Pro) and 972 (Gly-->Arg) in the insulin receptor substrate-1 (IRS-1) gene in 197 non-insulin-dependent diabetes mellitus (NIDDM) and 178 control subjects in Japan. 8037748 1994