rs1057519710
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
T
0.710
CausalMutation
CLINVAR
Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin.
23775962
2013
rs1057519710
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
T
0.710
CausalMutation
CLINVAR
KIT as a therapeutic target in metastatic melanoma.
21642685
2011
rs1057519710
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
C
0.710
CausalMutation
CLINVAR
Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification.
21690468
2011
rs1057519710
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
C
0.710
CausalMutation
CLINVAR
KIT as a therapeutic target in metastatic melanoma.
21642685
2011
rs1057519710
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
T
0.710
CausalMutation
CLINVAR
Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure.
20088873
2010
rs1057519710
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.710
GeneticVariation
BEFREE
Finally, we found significant growth suppressive effects of sunitinib in two acral melanoma cell lines; one harboring the D820Y mutation and one showing SCF-dependent KIT activation.
19035443
2009
rs1057519710
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
C
0.710
CausalMutation
CLINVAR
Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor.
18955458
2008
rs1057519710
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
C
0.710
CausalMutation
CLINVAR
Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412.
15790786
2005
rs1057519710
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
C
0.710
CausalMutation
CLINVAR
Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumours.
11276010
2001
rs1057519710
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
C
0.710
CausalMutation
CLINVAR
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.
9438854
1998
rs1057519710
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
C
0.710
CausalMutation
CLINVAR
Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines.
7530509
1995