KRAS, KRAS proto-oncogene, GTPase, 3845

N. diseases: 1213; N. variants: 54
Disease: ovarian neoplasm ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs61764370
rs61764370
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		0.030 GeneticVariation BEFREE Recently, a variant allele in the 3'UTR of the KRAS gene (rs61764370 T>G) was shown to be associated with an increased risk for developing non-small cell lung cancer, as well as ovarian cancer, and was most enriched in ovarian cancer patients from hereditary breast and ovarian cancer families. 20676756 2011
dbSNP: rs61764370
rs61764370
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		0.030 GeneticVariation BEFREE These data exclude the possibility of an association between rs61764370 and a clinically significant risk of ovarian cancer or of familial ovarian cancer. 21385923 2011
dbSNP: rs61764370
rs61764370
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease:
ovarian neoplasm 		0.030 GeneticVariation BEFREE In this study, we investigated a hypothesized association between an increased risk of OC and a variant allele of KRAS at rs61764370, referred to as the KRAS-variant, which disrupts a let-7 miRNA binding site in this oncogene. 20647319 2010