KRAS, KRAS proto-oncogene, GTPase, 3845

N. diseases: 1213; N. variants: 54
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913530
rs121913530
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0684249
Disease:
Carcinoma of lung
0.880 GeneticVariation BEFREE Although this mutation in KRAS accounts for 11% of all KRAS mutations in cancer, it is the most prominent KRAS mutant in lung cancer suggesting that G12C-specific inhibitors may provide a new approach for treating the subset of lung cancer patients harboring this mutant allele. 30366101 2019
dbSNP: rs121913530
rs121913530
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0684249
Disease:
Carcinoma of lung
0.880 GeneticVariation BEFREE We developed an integrative pharmacogenomics analysis to identify potential drug targets to overcome MEK/ERK inhibitor resistance in lung cancer cell lines with KRAS(G12C) mutation (n = 12). 31668570 2019
dbSNP: rs121913530
rs121913530
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0684249
Disease:
Carcinoma of lung
0.880 GeneticVariation BEFREE Adding mTOR and IGF1R inhibitors to ARS-1620 greatly improves its effectiveness on KRAS-G12C mutant lung cancer cells in vitro and in mouse models. 31534020 2019
dbSNP: rs121913530
rs121913530
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0684249
Disease:
Carcinoma of lung
0.880 GeneticVariation BEFREE To substantiate these results, an allitinib-sensitive lung cancer-derived cell line (H292) was transfected with plasmids carrying the two most common activating KRAS mutations (p.G12D and p.G12S). 26920031 2016
dbSNP: rs121913530
rs121913530
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0684249
Disease:
Carcinoma of lung
0.880 GeneticVariation BEFREE Since hypoxic microenvironments select for tumor cells with diminished therapeutic response, we investigated whether hypoxia unequally increases resistance to 3-BrPA in wt p53 MelJuso melanoma harbouring (Q61L)-mutant NRAS and wt BRAF, C8161 melanoma with (G12D)-mutant KRAS (G464E)-mutant BRAF, and A549 lung carcinoma with a KRAS (G12S)-mutation. 27863474 2016
dbSNP: rs121913530
rs121913530
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0684249
Disease:
Carcinoma of lung
0.880 GeneticVariation BEFREE Next generation sequencing performed on the Ion Torrent platforms by the Ion Ampliseq Colon and Lung Cancer panel showed a similar genomic profile in both neoplastic sites with a concurrent KRAS G12C mutation. 25900221 2015
dbSNP: rs121913530
rs121913530
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0684249
Disease:
Carcinoma of lung
0.880 GeneticVariation BEFREE Gene-expression profiles in lung cancer cell lines and surgically resected lung AC revealed that KRAS-G12C mutants had an epithelial to mesenchymal transition and a KRAS-independent phenotype. 25170638 2014
dbSNP: rs121913530
rs121913530
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0684249
Disease:
Carcinoma of lung
0.880 GeneticVariation BEFREE Our study demonstrated that TRAIL significantly suppressed cell survival, by inducing apoptosis in a dose-dependent manner, in the pancreatic cancer BxPC-3 (wild type G12) and lung cancer A549 (G12S) cell lines. 20848283 2011
dbSNP: rs121913530
rs121913530
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0684249
Disease:
Carcinoma of lung
0.880 GeneticVariation UNIPROT
dbSNP: rs121913530
rs121913530
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0684249
Disease:
Carcinoma of lung
A 0.880 CausalMutation CLINVAR
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia
0.820 GeneticVariation BEFREE We report on an infant with JMML with somatic KRAS G12A mutation and monosomy 7 who achieved sustained remission following azacitidine monotherapy. 31250550 2019
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia
0.820 GeneticVariation BEFREE In the present study, we report 2 patients with somatic mosaicism for oncogenic NRAS mutations (G12D and G12S) associated with the development of JMML. 22753870 2012
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia
A 0.820 CausalMutation CLINVAR KRAS(G12V) enhances proliferation and initiates myelomonocytic differentiation in human stem/progenitor cells via intrinsic and extrinsic pathways. 21169357 2011
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia
T 0.820 CausalMutation CLINVAR KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay. 19358724 2009
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia
A 0.820 CausalMutation CLINVAR KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay. 19358724 2009
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia
A 0.820 CausalMutation CLINVAR Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. 19047918 2009
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia
T 0.820 CausalMutation CLINVAR Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. 19047918 2009
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia
T 0.820 CausalMutation CLINVAR Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. 17910045 2008
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia
0.820 GeneticVariation UNIPROT Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. 17332249 2007
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia
A 0.820 CausalMutation CLINVAR Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. 17332249 2007
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia
A 0.820 CausalMutation CLINVAR Cardio-facio-cutaneous and Noonan syndromes due to mutations in the RAS/MAPK signalling pathway: genotype-phenotype relationships and overlap with Costello syndrome. 17704260 2007
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia
T 0.820 CausalMutation CLINVAR Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. 17332249 2007
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia
T 0.820 CausalMutation CLINVAR KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. 15696205 2005
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia
A 0.820 CausalMutation CLINVAR KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. 15696205 2005
dbSNP: rs121913529
rs121913529
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0349639
Disease:
Juvenile Myelomonocytic Leukemia
T 0.820 CausalMutation CLINVAR Somatic PTPN11 mutations in childhood acute myeloid leukaemia. 15842656 2005