LEPR, leptin receptor, 3953

N. diseases: 416; N. variants: 57
Disease: Diabetes Mellitus, Non-Insulin-Dependent ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1137100
rs1137100
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.040 GeneticVariation BEFREE Interactions among moderate/severe periodontitis, rs1501299-GG, and rs1137100-GG were associated with an increased risk of T2DM. 31128439 2019
dbSNP: rs1137100
rs1137100
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.040 GeneticVariation BEFREE The present meta-analysis did not detect significant genetic associations between LEPR Q223R and K109R polymorphisms and T2D risk. 29293570 2018
dbSNP: rs1137100
rs1137100
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.040 GeneticVariation BEFREE In the present study, we examined whether common single nucleotide polymorphisms (SNPs) in the leptin (LEP; 19G>A) gene and its receptor (LEPR; Q223R and K109R) are associated with birth weight and adult metabolic risk factors for type 2 diabetes in twins. 18490929 2008
dbSNP: rs1137100
rs1137100
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.040 GeneticVariation BEFREE Two polymorphisms (Lys109Arg, Gln223Arg) in the extracellular domain of the leptin receptor predicted the conversion to type 2 diabetes in high-risk individuals with IGT. 15997246 2005