LEPR, leptin receptor, 3953

N. diseases: 416; N. variants: 57
Disease: Polycystic Ovary Syndrome ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1137101
rs1137101
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0032460
Disease:
Polycystic Ovary Syndrome 		0.040 GeneticVariation BEFREE Our meta-analysis suggested that LEPR rs1137101, PPARG rs1801282, and rs3856806 polymorphisms were all significantly associated with individual susceptibility to PCOS in certain populations. 31412346 2019
dbSNP: rs1137101
rs1137101
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0032460
Disease:
Polycystic Ovary Syndrome 		0.040 GeneticVariation BEFREE Despite previous suggestion about a relationship between rs1137101, serum leptin levels, and PCOS, our studies do not show any statistical association and further investigations; possibly by also evaluating obese patients should be needed to elucidate this issue better. 30635060 2019
dbSNP: rs1137101
rs1137101
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0032460
Disease:
Polycystic Ovary Syndrome 		0.040 GeneticVariation BEFREE LEPR Lys109Arg (rs1137100) and Gln223Arg (rs1137101) polymorphisms of PCOS patients and the controls were genotyped. 29749830 2017
dbSNP: rs1137101
rs1137101
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0032460
Disease:
Polycystic Ovary Syndrome 		0.040 GeneticVariation BEFREE Moreover, genotype combination and haplotype analyses indicate that Gln223Arg and Pro1019Pro polymorphisms of LEPR are significantly associated with the risk of PCOS</span>. 23769971 2013