LPA, lipoprotein(a), 4018

N. diseases: 340; N. variants: 49
Disease: Aortic Valve Stenosis ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10455872
rs10455872
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0003507
Disease:
Aortic Valve Stenosis 		0.030 GeneticVariation BEFREE We genotyped the CAD-associated variants at the LPA (rs10455872) and 9p21 loci (rs1333049) in the GeneCAST (Genetics of Calcific Aortic STenosis) Consortium and conducted a meta-analysis for their association with AVS. 30482443 2019
dbSNP: rs10455872
rs10455872
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0003507
Disease:
Aortic Valve Stenosis 		0.030 GeneticVariation BEFREE Both LPA variants were associated with AS, with a per risk allele odds ratio of 1.34 (95% CI, 1.23-1.47; P = 1.7 × 10-10) for rs1</span>0455872 and 1.31 (95% CI, 1.09-1.58; P = 3.6 × 10-3) for rs3798220 after adjusting for age, age2, and sex. 29128868 2018
dbSNP: rs10455872
rs10455872
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0003507
Disease:
Aortic Valve Stenosis 		0.030 GeneticVariation BEFREE The rs10455872 variant, which is associated with higher lipoprotein(a) levels, is also associated with increased risk of AVS, suggesting that this association may be causal. 24704946 2014