LRP1, LDL receptor related protein 1, 4035

N. diseases: 252; N. variants: 23
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11172113
rs11172113
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0149931
Disease:
Migraine Disorders
0.850 GeneticVariation BEFREE To further check if these variants differ by ethnicity, three single nucleotide polymorphisms (SNPs) (rs4379368, rs10504861and rs11172113) were genotyped here to find association with migraine susceptibility from North Indian population. 31505242 2019
dbSNP: rs11172113
rs11172113
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0149931
Disease:
Migraine Disorders
0.850 GeneticVariation GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
dbSNP: rs11172113
rs11172113
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0149931
Disease:
Migraine Disorders
T 0.850 GeneticVariation GWASCAT Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. 27322543 2016
dbSNP: rs11172113
rs11172113
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0149931
Disease:
Migraine Disorders
0.850 GeneticVariation BEFREE To further replicate the GWAS findings, we investigated the 3 variants rs2651899 (1p36.32, PRDM16), rs10166942 (2q37.1, TRPM8), and rs11172113 (12q13.3, LRP1) for their association with migraine in the Chinese Han population. 24666033 2014
dbSNP: rs11172113
rs11172113
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0149931
Disease:
Migraine Disorders
0.850 GeneticVariation BEFREE We report significant influence of rs1835740, LRP1 rs11172113 and PRDM16 rs2651899 polymorphisms on migraine susceptibility in the North Indian population. 24266335 2014
dbSNP: rs11172113
rs11172113
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0149931
Disease:
Migraine Disorders
0.850 GeneticVariation BEFREE The meta-analysis confirmed the previous three genome-wide significant associated SNPs (rs2651899, rs10166942 and rs11172113</span>) to confer risk of migraine. 23294458 2013
dbSNP: rs11172113
rs11172113
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0149931
Disease:
Migraine Disorders
0.850 GeneticVariation GWASCAT Genome-wide meta-analysis identifies new susceptibility loci for migraine. 23793025 2013
dbSNP: rs11172113
rs11172113
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0149931
Disease:
Migraine Disorders
0.850 GeneticVariation GWASDB Genome-wide meta-analysis identifies new susceptibility loci for migraine. 23793025 2013
dbSNP: rs11172113
rs11172113
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0149931
Disease:
Migraine Disorders
0.850 GeneticVariation GWASCAT Genome-wide association analysis identifies susceptibility loci for migraine without aura. 22683712 2012
dbSNP: rs11172113
rs11172113
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0149931
Disease:
Migraine Disorders
0.850 GeneticVariation GWASDB Genome-wide association analysis identifies susceptibility loci for migraine without aura. 22683712 2012
dbSNP: rs11172113
rs11172113
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0149931
Disease:
Migraine Disorders
0.850 GeneticVariation BEFREE In a population-based genome-wide analysis including 5,122 migraineurs and 18,108 non-migraineurs, rs2651899 (1p36.32, PRDM16), rs10166942 (2q37.1, TRPM8) and rs11172113 (12q13.3, LRP1) were among the top seven associations (P < 5 × 10(-6)) with migraine. 21666692 2011
dbSNP: rs11172113
rs11172113
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0149931
Disease:
Migraine Disorders
T 0.850 GeneticVariation GWASCAT In a population-based genome-wide analysis including 5,122 migraineurs and 18,108 non-migraineurs, rs2651899 (1p36.32, PRDM16), rs10166942 (2q37.1, TRPM8) and rs11172113 (12q13.3, LRP1) were among the top seven associations (P < 5 × 10(-6)) with migraine. 21666692 2011
dbSNP: rs11172113
rs11172113
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0149931
Disease:
Migraine Disorders
T 0.850 GeneticVariation GWASDB In a population-based genome-wide analysis including 5,122 migraineurs and 18,108 non-migraineurs, rs2651899 (1p36.32, PRDM16), rs10166942 (2q37.1, TRPM8) and rs11172113 (12q13.3, LRP1) were among the top seven associations (P < 5 × 10(-6)) with migraine. 21666692 2011
dbSNP: rs1466535
rs1466535
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0162871
Disease:
Aortic Aneurysm, Abdominal
0.840 GeneticVariation BEFREE Our work supports the evidence that the T allele of the rs1466535 LRP1 polymorphism is an independent risk factor for abdominal aortic aneurysm. 24423473 2015
dbSNP: rs1466535
rs1466535
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0162871
Disease:
Aortic Aneurysm, Abdominal
0.840 GeneticVariation BEFREE Genetic polymorphisms all previously reported as showing a significant correlation with AAA with functional effects on the expression or function were determined by analysis of the genomic DNA, including angiotensin 1 receptor (rs5186), interleukin-10 (IL-10; rs1800896), methyl-tetrahydrofolate reductase (rs1801133), low-density lipoprotein receptor-related protein 1 (LRP1; rs1466535), angiotensin-converting enzyme (rs1799752), and several matrix metalloproteinase 9 (MMP-9) single nucleotide polymorphisms. 24801553 2014
dbSNP: rs1466535
rs1466535
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0162871
Disease:
Aortic Aneurysm, Abdominal
0.840 GeneticVariation BEFREE An association between rs1466535 low density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism and abdominal aortic aneurysm (AAA) was recently demonstrated. 25238221 2014
dbSNP: rs1466535
rs1466535
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0162871
Disease:
Aortic Aneurysm, Abdominal
C 0.840 GeneticVariation GWASDB No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA. 22055160 2011
dbSNP: rs1466535
rs1466535
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0162871
Disease:
Aortic Aneurysm, Abdominal
0.840 GeneticVariation BEFREE No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA. 22055160 2011
dbSNP: rs1466535
rs1466535
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0162871
Disease:
Aortic Aneurysm, Abdominal
C 0.840 GeneticVariation GWASCAT No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA. 22055160 2011
dbSNP: rs11172113
rs11172113
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0338480
Disease:
Common Migraine
T 0.800 GeneticVariation GWASCAT Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. 27322543 2016
dbSNP: rs11172113
rs11172113
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0338480
Disease:
Common Migraine
0.800 GeneticVariation GWASDB Genome-wide meta-analysis identifies new susceptibility loci for migraine. 23793025 2013
dbSNP: rs11172113
rs11172113
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C1518922
Disease:
peak expiratory flow (procedure)
T 0.700 GeneticVariation GWASCAT New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. 30804560 2019
dbSNP: rs4759277
rs4759277
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0346629
Disease:
Malignant neoplasm of large intestine
A 0.700 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
dbSNP: rs4759277
rs4759277
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C2677123
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
A 0.700 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
dbSNP: rs4759277
rs4759277
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C3554460
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
A 0.700 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019