MIR146A, microRNA 146a, 406938

N. diseases: 505; N. variants: 3
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE In summary, miR-146a rs2910164 GC is significantly associated with BC in the Pakistani population. 30963551 2019
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C2239176
Disease:
Liver carcinoma
0.100 GeneticVariation BEFREE Previous studies have shown that miRNA-146a rs2910164 polymorphism can be associated with the pathogenesis of liver diseases such as hepatocellular carcinoma. 30624803 2019
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C0678222
Disease:
Breast Carcinoma
0.100 GeneticVariation BEFREE In summary, miR-146a rs2910164 GC is significantly associated with BC in the Pakistani population. 30963551 2019
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.100 GeneticVariation BEFREE <b>Conclusions:</b> The association of miR-146a rs2910164 (G/C) with RA was not found. 31235484 2019
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C1956346
Disease:
Coronary Artery Disease
0.100 GeneticVariation BEFREE In the subgroups, rs2910164 and rs3746444 were only associated with CVDs, especially CAD. 30642078 2019
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C2239176
Disease:
Liver carcinoma
0.100 GeneticVariation BEFREE We evaluated the associations of <i>miR-499A</i>>G (rs3746444), <i>miR-149C</i>>T (rs2292832), <i>miR-196a2T</i>>C (rs11614913), and <i>miR-146aG</i>>C (rs2910164) with HCC susceptibility in 100 HCC patients (70 males and 30 females) and 120 healthy controls (70 males and 50 females), using the PCR-restriction fragment length polymorphism method. 30215231 2019
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C0684249
Disease:
Carcinoma of lung
0.100 GeneticVariation BEFREE MiR-146a rs2910164 polymorphism might be associated with the susceptibility to lung cancer and nasopharyngeal carcinoma. 29127520 2018
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE miRNA 196a2(rs11614913) & 146a(rs2910164) polymorphisms & breast cancer risk for women in an Iranian population. 29965793 2018
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C0678222
Disease:
Breast Carcinoma
0.100 GeneticVariation BEFREE Conclusion Our data indicate that miR-146a (rs2910164</span>) and miR-27a (rs895819) variants contribute to breast cancer. 29521182 2018
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C1306460
Disease:
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE These findings suggested that SNPs rs71428439 (miR-149), rs2910164 (miR-146a), rs928508 (mir-30c-1) and rs629367 (let-7a-2) were associated with the lung cancer prevalence, polymorphisms of rs11614913 (miR-196a-2) and rs9280508 (miR-30c-1) significantly influenced the patients' response to platinum-based chemotherapy, which may serve as potential clinical biomarkers to predict lung cancer risk and platinum-based chemotherapy response. 30069329 2018
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Analysis of the data based on race revealed that rs2910164 (miR-146a) polymorphism may decrease the risk of CRC among Europeans, in a co dominant model [OR = 0.81, 95% CI 0.66-0.99, p = 0.04], but not among Asians. 30447914 2018
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE Subgroup analyses based on ethnicity, source of control group, and country indicated that there were strong associations between miRNA-146a rs2910164 and cancer risk. 29750042 2018
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE Thus, the present study explored the association between five common functional polymorphisms in miRNAs (i.e., miRNA-196a2C>T, rs11614913; miRNA-146aG>C, rs2910164; miRNA-423C>A, rs6505162; miRNA-608G>C, rs4919510; miRNA-27aC>T, rs895819) and the risk of BC. 29782194 2018
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C0242379
Disease:
Malignant neoplasm of lung
0.100 GeneticVariation BEFREE The results indicated that lung cancer risk was significantly associated with miRNA-196a2 rs11614913 and miRNA-146a rs2910164. 29750042 2018
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C1306460
Disease:
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE The results indicated that lung cancer risk was significantly associated with miRNA-196a2 rs11614913 and miRNA-146a rs2910164. 29750042 2018
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE MiR-146a rs2910164 polymorphism and overall cancer susceptibility were significantly uncorrelated in all genetic models. 29127520 2018
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C1956346
Disease:
Coronary Artery Disease
0.100 GeneticVariation BEFREE In addition, the presence of a minor allele of the rs2910164 polymorphism was significantly associated with risk of depression in patients with CAD. 29749487 2018
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE Conclusion Our data indicate that miR-146a (rs2910164</span>) and miR-27a (rs895819) variants contribute to breast cancer. 29521182 2018
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C0684249
Disease:
Carcinoma of lung
0.100 GeneticVariation BEFREE The results indicated that lung cancer risk was significantly associated with miRNA-196a2 rs11614913 and miRNA-146a rs2910164. 29750042 2018
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C1306459
Disease:
Primary malignant neoplasm
0.100 GeneticVariation BEFREE The miRNA-146a rs2910164 C>G polymorphism may contribute to the development of cancer. 29983589 2018
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE It was shown that 6 miRNAs SNPs (miR-608 rs4919510, miR-492 rs2289030, miR-378 rs1076064, miR-499 rs4919510, miR-149 rs2292832, miR-196a2 rs11614913) were associated with better cancer overall survival (OS) while let-7i rs10877887 was associated with poor OS; the homozygous and heterozygote genotype of miR-423 were related to poor cancer relapse-free survival (RFS) when compared with the wild genotype; miR-146 rs2910164 was linked to favorable cancer DFS while miR-196a2 rs11614913 was associated with poor DFS. 30619739 2018
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C1306459
Disease:
Primary malignant neoplasm
0.100 GeneticVariation BEFREE It was shown that 6 miRNAs SNPs (miR-608 rs4919510, miR-492 rs2289030, miR-378 rs1076064, miR-499 rs4919510, miR-149 rs2292832, miR-196a2 rs11614913) were associated with better cancer overall survival (OS) while let-7i rs10877887 was associated with poor OS; the homozygous and heterozygote genotype of miR-423 were related to poor cancer relapse-free survival (RFS) when compared with the wild genotype; miR-146 rs2910164 was linked to favorable cancer DFS while miR-196a2 rs11614913 was associated with poor DFS. 30619739 2018
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE The miRNA-146a rs2910164 C>G polymorphism may contribute to the development of cancer. 29983589 2018
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C1306459
Disease:
Primary malignant neoplasm
0.100 GeneticVariation BEFREE Subgroup analyses based on ethnicity, source of control group, and country indicated that there were strong associations between miRNA-146a rs2910164 and cancer risk. 29750042 2018
dbSNP: rs2910164
rs2910164
Entrez Id: 406938;107075116
Gene Symbol: MIR146A;MIR3142HG
MIR146A;MIR3142HG
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.100 GeneticVariation BEFREE Serum miRNA-146a was negatively correlated with anti-nuclear antibodies (ANA). miRNA-146a (rs2910164) genotyping revealed that the GG genotype and the frequency of the G allele were significantly higher in RA patients compared to the controls. miRNA-499 (rs3746444), genotyping revealed that the CC genotype and the frequency of the C allele were significantly higher. 29700729 2018