MAPT, microtubule associated protein tau, 4137

N. diseases: 469; N. variants: 292
Disease: Parkinson Disease ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs9468
rs9468
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0030567
Disease:
Parkinson Disease 		0.030 GeneticVariation BEFREE In addition, rs9468 (MAPT) was associated with a decreased risk of PD (P-value = 5.70E-7). 31430546 2019
dbSNP: rs9468
rs9468
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0030567
Disease:
Parkinson Disease 		0.030 GeneticVariation BEFREE Patients were also genotyped for three polymorphisms associated with cognitive change in Parkinson's disease and related disorders: (i) rs4680 for COMT Val158Met polymorphism; (ii) rs9468 for MAPT H1 versus H2 haplotype; and (iii) rs429358 for APOE-ε2, 3, 4. 25080285 2014
dbSNP: rs9468
rs9468
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0030567
Disease:
Parkinson Disease 		0.030 GeneticVariation BEFREE We also observed suggestive association between AD and the marker rs9468, which defines the H1 haplotype, an extended haplotype that spans the MAPT gene and has previously been implicated in other neurodegenerative disorders including Parkinson's disease, progressive supranuclear palsy, and corticobasal degeneration. 22027014 2012