MDM2, MDM2 proto-oncogene, 4193

N. diseases: 702; N. variants: 30
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1353702185
rs1353702185
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0025202
Disease:
melanoma
0.050 GeneticVariation BEFREE The data suggest for the first time that P53 Arg72Pro, MDM2 c.+309T>G, BAX c.-248G>A, and BCL2 c.-717C>A polymorphisms, enrolled in apoptosis pathways, constitute distinct determinants of CM in women and men. 24461648 2014
dbSNP: rs1353702185
rs1353702185
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0025202
Disease:
melanoma
0.050 GeneticVariation BEFREE In melanoma, the effects for SNP309 and the related tumor protein p53 (TP53) Arg72Pro are inconsistent among published reports. 22336942 2012
dbSNP: rs1353702185
rs1353702185
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0025202
Disease:
melanoma
0.050 GeneticVariation BEFREE No associations were found among the SNP309, Arg72Pro, risk of CM, age at diagnosis and presence of metastasis in total subjects and when stratified according to the gender. 20535124 2010
dbSNP: rs1353702185
rs1353702185
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0025202
Disease:
melanoma
0.050 GeneticVariation BEFREE We evaluated the effect of MDM2 SNP309 and its interaction with the p53 Arg72Pro polymorphism on pigmentary phenotypes and skin cancer risk in a nested case-control study within the Nurses' Health Study (NHS) among 219 melanoma cases, 286 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 873 controls, and among controls from other studies. 18814047 2009
dbSNP: rs1353702185
rs1353702185
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0025202
Disease:
melanoma
0.050 GeneticVariation BEFREE Prospectively enrolled melanoma patients (N = 227) were evaluated for MDM2 SNP309 and the related polymorphism, p53 Arg72Pro. 19318491 2009