rs1353702185
×
Entrez Id:
4193
Gene Symbol:
MDM2
MDM2
Neoplasms
0.100
GeneticVariation
BEFREE
ERCC1 Lys259Thr (rs735482), ERCC2 Lys751Gln (rs13181), ERCC5 His46His C>T (rs1047768), XRCC1 Arg399Gln (rs25487), TP53 Arg72Pro (rs1042522) and MDM2 309T>G (rs2279744) were analyzed on tumor DNA.
28351583
2017
rs1353702185
×
Entrez Id:
4193
Gene Symbol:
MDM2
MDM2
Neoplasms
0.100
GeneticVariation
BEFREE
Single nucleotide polymorphisms (SNP) in codon Arg72Pro of P53 results in impairment of the tumor suppressor activity of the gene.
23167335
2012
rs1353702185
×
Entrez Id:
4193
Gene Symbol:
MDM2
MDM2
Neoplasms
0.100
GeneticVariation
BEFREE
The Arg72Pro genotype has no significant effects in patients with TP53 mutated tumors , in which p53 is non-functional.
23071787
2012
rs1353702185
×
Entrez Id:
4193
Gene Symbol:
MDM2
MDM2
Neoplasms
0.100
GeneticVariation
BEFREE
The analyses indicate that MDM2 SNP309 serves as a tumor susceptibility marker, and that there is an association between MDM2 SNP309 and p53 Arg72Pro regarding tumor susceptibility.
21619694
2011
rs1353702185
×
Entrez Id:
4193
Gene Symbol:
MDM2
MDM2
Neoplasms
0.100
GeneticVariation
BEFREE
There was no evidence of such an effect on survival within the TP53-mutated tumor group for TP53 R72P carriers but a suggestion of an effect for MDM2 SNP309 c arriers (GG vs. TT-genotype HR 2.99, P = 0.06).
21667122
2011
rs1353702185
×
Entrez Id:
4193
Gene Symbol:
MDM2
MDM2
Neoplasms
0.100
GeneticVariation
BEFREE
MDM2 SNP309 and p53 Arg72Pro in cutaneous melanoma: association between SNP309 GG genotype and tumor Breslow thickness.
20535124
2010
rs1353702185
×
Entrez Id:
4193
Gene Symbol:
MDM2
MDM2
Neoplasms
0.100
GeneticVariation
BEFREE
The germ-line polymorphisms TP53 Arg72Pro and MDM2 SNP309 T>G are risk factors for tumor development and affect response to chemotherapy and survival in several cancers, but their prognostic and predictive value in patients with high-grade osteosarcomas is not yet defined.
19451596
2009
rs1353702185
×
Entrez Id:
4193
Gene Symbol:
MDM2
MDM2
Neoplasms
0.100
GeneticVariation
BEFREE
Polymorphisms were identified within the TP53 (R72P and Ins16) and MDM2 (SNP309) genes that may further diminish TP53 tumor suppressor activity.
19046423
2008
rs1353702185
×
Entrez Id:
4193
Gene Symbol:
MDM2
MDM2
Neoplasms
0.100
GeneticVariation
BEFREE
In addition, the TP53 R72P polymorphism and chromosome 1p/19 q status, a major biomarker in oligodendroglial t</span>umors , were investigated.
18262501
2008
rs1353702185
×
Entrez Id:
4193
Gene Symbol:
MDM2
MDM2
Neoplasms
0.100
GeneticVariation
BEFREE
Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li-Fraumeni syndrome.
16258005
2006