Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs12917
rs12917
Entrez Id: 4255;105378560
Gene Symbol: MGMT;LOC105378560
MGMT;LOC105378560
CUI: C0017638
Disease:
Glioma
0.040 GeneticVariation BEFREE In summary, the T/T <i>genotype of MGMT</i> rs12917 is likely to be linked to an enhanced susceptibility to cancer overall, especially glioma, in the Caucasian population. 30232235 2018
dbSNP: rs12917
rs12917
Entrez Id: 4255;105378560
Gene Symbol: MGMT;LOC105378560
MGMT;LOC105378560
CUI: C0017638
Disease:
Glioma
0.040 GeneticVariation BEFREE This meta-analysis suggests that glioma susceptibility is associated with rs1799782 and rs25487 of X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), rs1805377 of XRCC4, rs1800067 of excision repair cross-complementing rodent repair deficiency complementation group 4 (ERCC4) and rs3212986 of ERCC1 in Asian population, and rs12917 of O-6-methylguanine-DNA methyltransferase (MGMT) and rs1136410 of poly(ADP-ribose) polymerase 1 (PARP1) in Caucasian population. 27055523 2017
dbSNP: rs12917
rs12917
Entrez Id: 4255;105378560
Gene Symbol: MGMT;LOC105378560
MGMT;LOC105378560
CUI: C0017638
Disease:
Glioma
0.040 GeneticVariation BEFREE We found that SNPs rs3212986 (odds ratio [OR] = 1.35 (1.08-1.68), P = .008), rs13181 (OR = 1.18 (1.06-1.31), P = .002), and rs25487 (OR = 1.12 (1.03-1.22), P = .007) in DNA repair genes ERCC1, ERCC2 (XPD), and XRCC1 may increase the risk of glioma, while polymorphisms rs1136410 (OR = 0.78 (0.68-0.89), P = .0004) and rs12917 (OR = 0.84 (0.73-0.96), P = .01) in PARP1(ADPRT) and MGMT are associated with decreased susceptibility to glioma. 24500421 2014
dbSNP: rs12917
rs12917
Entrez Id: 4255;105378560
Gene Symbol: MGMT;LOC105378560
MGMT;LOC105378560
CUI: C0017638
Disease:
Glioma
0.040 GeneticVariation BEFREE Furthermore, the multifactor dimensionality reduction and classification and regression tree analyses identified MGMT F84L as the predominant risk factor for glioma and revealed strong interactions among ionizing radiation exposure, PARP1 A762V, MGMT F84L, and APEX1 E148D. 19124499 2009