|
rs9653226
|
MYCN;MYCNOS
|
Childhood Neuroblastoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that only rs57961569 G>A was associated with neuroblastoma risk (GA vs GG: adjusted odds ratio =0.76, 95% confidence interval =0.60-0.98, <i>P</i>=0.033), while the other 3 SNPs were not (rs9653226 T>C, rs13034994 A>G, and rs60226897 G>A).
|
29997440 |
2018 |
|
rs9653226
|
MYCN;MYCNOS
|
Neuroblastoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that only rs57961569 G>A was associated with neuroblastoma risk (GA vs GG: adjusted odds ratio =0.76, 95% confidence interval =0.60-0.98, <i>P</i>=0.033), while the other 3 SNPs were not (rs9653226 T>C, rs13034994 A>G, and rs60226897 G>A).
|
29997440 |
2018 |
|
rs772399455
|
MYCN;MYCNOS
|
Carcinogenesis
|
|
0.010 |
GeneticVariation |
BEFREE |
Foxm1 transcription factor is required for the initiation of lung tumorigenesis by oncogenic Kras(G12D.).
|
24213573 |
2014 |
|
rs772399455
|
MYCN;MYCNOS
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Transgenic expression of activated Kras(G12D) in mouse respiratory epithelium is sufficient to induce lung adenocarcinomas; however, transcriptional mechanisms regulated by K-Ras during the initiation of lung cancer remain poorly understood.
|
24213573 |
2014 |
|
rs772399455
|
MYCN;MYCNOS
|
Lung Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
Conditional deletion of Foxm1 from Kras(G12D)-expressing respiratory epithelium prevented the initiation of lung tumors in vivo.
|
24213573 |
2014 |
|
rs772399455
|
MYCN;MYCNOS
|
Adenocarcinoma of lung (disorder)
|
|
0.010 |
GeneticVariation |
BEFREE |
Transgenic expression of activated Kras(G12D) in mouse respiratory epithelium is sufficient to induce lung adenocarcinomas; however, transcriptional mechanisms regulated by K-Ras during the initiation of lung cancer remain poorly understood.
|
24213573 |
2014 |
|
rs772399455
|
MYCN;MYCNOS
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Transgenic expression of activated Kras(G12D) in mouse respiratory epithelium is sufficient to induce lung adenocarcinomas; however, transcriptional mechanisms regulated by K-Ras during the initiation of lung cancer remain poorly understood.
|
24213573 |
2014 |
|
rs772399455
|
MYCN;MYCNOS
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Transgenic expression of activated Kras(G12D) in mouse respiratory epithelium is sufficient to induce lung adenocarcinomas; however, transcriptional mechanisms regulated by K-Ras during the initiation of lung cancer remain poorly understood.
|
24213573 |
2014 |
|
rs1200941109
|
MYCN;MYCNOS
|
Neuroectodermal Tumor, Primitive
|
|
0.010 |
GeneticVariation |
BEFREE |
H3.3 G34R mutations in pediatric primitive neuroectodermal tumors of central nervous system (CNS-PNET) and pediatric glioblastomas: possible diagnostic and therapeutic implications?
|
23354654 |
2013 |
|
rs1200941109
|
MYCN;MYCNOS
|
Central Nervous System Embryonal Tumor, Not Otherwise Specified
|
|
0.010 |
GeneticVariation |
BEFREE |
Multiplex ligation-dependent probe amplification analysis revealed PDGFR-alpha amplification and EGFR gain in two cases and N-Myc amplification in one case of H3.3 G34R mutated CNS-PNET.
|
23354654 |
2013 |
|
rs1200941109
|
MYCN;MYCNOS
|
Glioblastoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The K27M (AAG → ATG, lysine → methionine) mutation was found in 33 glioblastomas (26 %); the G34R (GGG → AGG, glycine → arginine) was observed in 6 glioblastomas (5.5 %).
|
23354654 |
2013 |
|
rs1200941109
|
MYCN;MYCNOS
|
Brain Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, because pediatric patients with glioblastoma and CNS-PNET are treated according to different therapeutic protocols, these findings may raise further concerns about the reliability of the histological diagnosis in the case of an undifferentiated brain tumor harbouring G34R H3.3 mutation.
|
23354654 |
2013 |
|
rs922324159
|
MYCN;MYCNOS
|
Diffuse Glioma
|
|
0.010 |
GeneticVariation |
BEFREE |
N-myc(T58A) cerebellar and brain stem NSCs generated medulloblastoma/primitive neuroectodermal tumors, whereas forebrain NSCs developed diffuse glioma.
|
22624711 |
2012 |
|
rs922324159
|
MYCN;MYCNOS
|
Medulloblastoma
|
|
0.010 |
GeneticVariation |
BEFREE |
N-myc(T58A) cerebellar and brain stem NSCs generated medulloblastoma/primitive neuroectodermal tumors, whereas forebrain NSCs developed diffuse glioma.
|
22624711 |
2012 |
|
rs922324159
|
MYCN;MYCNOS
|
Childhood Medulloblastoma
|
|
0.010 |
GeneticVariation |
BEFREE |
N-myc(T58A) cerebellar and brain stem NSCs generated medulloblastoma/primitive neuroectodermal tumors, whereas forebrain NSCs developed diffuse glioma.
|
22624711 |
2012 |
|
rs922324159
|
MYCN;MYCNOS
|
Neuroectodermal Tumor, Primitive
|
|
0.010 |
GeneticVariation |
BEFREE |
N-myc(T58A) cerebellar and brain stem NSCs generated medulloblastoma/primitive neuroectodermal tumors, whereas forebrain NSCs developed diffuse glioma.
|
22624711 |
2012 |
|
rs922324159
|
MYCN;MYCNOS
|
Adult Medulloblastoma
|
|
0.010 |
GeneticVariation |
BEFREE |
N-myc(T58A) cerebellar and brain stem NSCs generated medulloblastoma/primitive neuroectodermal tumors, whereas forebrain NSCs developed diffuse glioma.
|
22624711 |
2012 |
|
rs779000620
|
MYCN;MYCNOS
|
Esophageal Atresia
|
|
0.010 |
GeneticVariation |
BEFREE |
A previously unreported case with severe bilateral microphthalmia and oesophageal atresia has a de novo missense mutation, R74P, that alters a highly evolutionarily conserved residue within the high mobility group domain, which is critical for DNA-binding of SOX2.
|
16543359 |
2006 |