rs121917887
|
NME1;NME1-NME2
|
Childhood Neuroblastoma
|
|
0.080 |
GeneticVariation |
BEFREE |
We summarize and discuss nm23-H1 genetics and the prognosis of neuroblastoma, structural and functional changes associated with the S120G mutation of NDPK-A, as well as the evidence supporting the role of NDPK-A as a metastasis promoter.
|
28991262 |
2018 |
rs121917887
|
NME1;NME1-NME2
|
Childhood Neuroblastoma
|
|
0.080 |
GeneticVariation |
BEFREE |
Aggregation of the neuroblastoma-associated mutant (S120G) of the human nucleoside diphosphate kinase-A/NM23-H1 into amyloid fibrils.
|
21484438 |
2011 |
rs121917887
|
NME1;NME1-NME2
|
Childhood Neuroblastoma
|
|
0.080 |
GeneticVariation |
BEFREE |
The point mutation S120G in human nucleoside diphosphate kinase A, identified in patients with neuroblastoma, causes a protein folding defect.
|
19186179 |
2009 |
rs121917887
|
NME1;NME1-NME2
|
Childhood Neuroblastoma
|
|
0.080 |
GeneticVariation |
BEFREE |
Compared with its wild-type, NDPK-A(S120G) appears more effective in promoting neuroblastoma metastasis.
|
15280446 |
2004 |
rs121917887
|
NME1;NME1-NME2
|
Childhood Neuroblastoma
|
|
0.080 |
GeneticVariation |
BEFREE |
However, the k-pn type proline-96 to serine (P96S) and neuroblastoma type serine-120 to glycine (S120G) mutations of Nm23-H1 abrogated its inhibitory activity on colonization and invasion.
|
12859952 |
2003 |
rs121917887
|
NME1;NME1-NME2
|
Childhood Neuroblastoma
|
|
0.080 |
GeneticVariation |
BEFREE |
Prune protein interacts with the metastasis suppressor nm23-H1, but shows impaired affinity towards the nm23-H1 S120G mutant associated with advanced neuroblastoma.
|
11687967 |
2001 |
rs121917887
|
NME1;NME1-NME2
|
Childhood Neuroblastoma
|
|
0.080 |
GeneticVariation |
BEFREE |
Moreover, like the Killer-of-prune mutation in Drosophila NDK and the neuroblastoma Ser120 --> Gly mutation in human NDK-A/Nm23-H1, the Ser122 --> Pro substitution in NDK-B affects the stability of the protein toward heat and urea.
|
10400630 |
1999 |
rs121917887
|
NME1;NME1-NME2
|
Childhood Neuroblastoma
|
|
0.080 |
GeneticVariation |
BEFREE |
A similar ser120-gly mutation in NME1 has been found in human neuroblastoma, suggesting that mutation in this region may be a general phenomenon related to tumor progression.
|
7794272 |
1995 |