|
rs202102042
|
CLCN6;NPPA;NPPA-AS1
|
ATRIAL STANDSTILL 2
|
T |
0.800 |
CausalMutation |
CLINVAR |
|
|
|
|
rs202102042
|
CLCN6;NPPA;NPPA-AS1
|
ATRIAL STANDSTILL 2
|
|
0.800 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs202102042
|
CLCN6;NPPA;NPPA-AS1
|
Systolic Pressure
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
|
30578418 |
2019 |
|
rs5068
|
CLCN6;NPPA;NPPA-AS1
|
Diastolic blood pressure
|
|
0.700 |
GeneticVariation |
GWASCAT |
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
|
29455858 |
2018 |
|
rs5068
|
CLCN6;NPPA;NPPA-AS1
|
Systolic Pressure
|
|
0.700 |
GeneticVariation |
GWASCAT |
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
|
29455858 |
2018 |
|
rs12744757
|
CLCN6;NPPA;NPPA-AS1
|
Systolic Pressure
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.
|
28739976 |
2017 |
|
rs5063
|
CLCN6;NPPA;NPPA-AS1
|
Psoriasis
|
|
0.700 |
GeneticVariation |
GWASCAT |
Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis.
|
25854761 |
2015 |
|
rs587776851
|
CLCN6;NPPA;NPPA-AS1
|
Atrial Fibrillation, Familial, 6
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs61757261
|
CLCN6;NPPA;NPPA-AS1
|
Atrial Fibrillation, Familial, 6
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs5063
|
CLCN6;NPPA;NPPA-AS1
|
Hypertensive disease
|
|
0.060 |
GeneticVariation |
BEFREE |
The findings suggested that a common NPPA SNPs rs5063 was associated with serum ANP levels and ANP was prospectively associated with hypertension in the Chinese Han population.
|
31341238 |
2019 |
|
rs5063
|
CLCN6;NPPA;NPPA-AS1
|
Hypertensive disease
|
|
0.060 |
GeneticVariation |
BEFREE |
This study examined the SNPs AGT rs699 (Met235Thr), ADD1 rs4961 (Gly460Trp), NPPA rs5063 (Val32Met), GPX1 rs1050450 (Pro198Leu), and AGTR1 rs5186 (A1166C) in relation to hypertension and salt sensitivity.
|
27480094 |
2017 |
|
rs5063
|
CLCN6;NPPA;NPPA-AS1
|
Hypertensive disease
|
|
0.060 |
GeneticVariation |
BEFREE |
Carriers of rs5063 had lower NT-proANP levels (1427 versus 2291 pmol/L; P<0.001) and higher diastolic blood pressures (75 versus 73 mm Hg; P=0.009) and were at an increased risk of stroke when compared with wild-type subjects independent of age, sex, diabetes mellitus, hypertension, atrial fibrillation, and cholesterol levels (hazard ratio, 1.6; P=0.004).
|
25452597 |
2015 |
|
rs5063
|
CLCN6;NPPA;NPPA-AS1
|
Hypertensive disease
|
|
0.060 |
GeneticVariation |
BEFREE |
After adjusting for age, sex, BMI and hypertension status by logistic regression analysis, we found that NPPA rs5063 was significantly associated with both ischemic stroke (odds ratio [OR] 0.69; 95% confidence interval [CI], 0.52 to 0.90; P = 0.006) and cerebral hemorrhage(OR = 0.39; 95%CI, 0.19 to 0.78; P = 0.007).
|
25144711 |
2014 |
|
rs5063
|
CLCN6;NPPA;NPPA-AS1
|
Hypertensive disease
|
|
0.060 |
GeneticVariation |
BEFREE |
Two common single nucleotide polymorphisms (SNPs) in NPPA, rs5063 and rs5065, result in amino acid changes of the primary peptide and have been previously implicated in conditions associated with AF, including stroke and hypertension.
|
20543198 |
2010 |
|
rs5063
|
CLCN6;NPPA;NPPA-AS1
|
Hypertensive disease
|
|
0.060 |
GeneticVariation |
BEFREE |
Hazard ratios (95% CIs) for incident hypertension were 0.88 (0.80 to 0.96; P=0.005) for the rs5063 variant and 0.95 (0.90 to 1.00; P=0.068) for the rs5065 variant.
|
17984371 |
2007 |
|
rs5068
|
CLCN6;NPPA;NPPA-AS1
|
Hypertensive disease
|
|
0.030 |
GeneticVariation |
BEFREE |
In whites, the minor G allele of the atrial natriuretic peptide (ANP) genetic variant rs5068 is associated with higher circulating levels of ANP and B-type natriuretic peptide (BNP), lower risk of hypertension, higher high-density lipoprotein (HDL) cholesterol plasma levels, and lower prevalence of obesity and metabolic syndrome.
|
29253899 |
2017 |
|
rs5063
|
CLCN6;NPPA;NPPA-AS1
|
Atrial Fibrillation
|
|
0.030 |
GeneticVariation |
BEFREE |
Carriers of rs5063 had lower NT-proANP levels (1427 versus 2291 pmol/L; P<0.001) and higher diastolic blood pressures (75 versus 73 mm Hg; P=0.009) and were at an increased risk of stroke when compared with wild-type subjects independent of age, sex, diabetes mellitus, hypertension, atrial fibrillation, and cholesterol levels (hazard ratio, 1.6; P=0.004).
|
25452597 |
2015 |
|
rs5065
|
CLCN6;NPPA;NPPA-AS1
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation |
BEFREE |
The presence of the rs5065 ANP polymorphism is potentially associated with a reduced risk of CAD as well as with reduced severity of CAD independent of the general risk factors of CAD.
|
24487939 |
2014 |
|
rs5065
|
CLCN6;NPPA;NPPA-AS1
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation |
BEFREE |
The ANP rs5065 (2238T>C) C allele seems to exert a protective effect against CAD in T2D patients of African descent.
|
22170009 |
2012 |
|
rs5065
|
CLCN6;NPPA;NPPA-AS1
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation |
BEFREE |
The MA of rs5065 ANP gene variant associates with increased susceptibility to ACS and has unfavorable prognostic value in CAD.
|
22575314 |
2012 |
|
rs5065
|
CLCN6;NPPA;NPPA-AS1
|
Hypertensive disease
|
|
0.030 |
GeneticVariation |
BEFREE |
Minor alleles of NPPA rs5068, rs5065 and rs198358 were associated with less history of hypertension; minor alleles of NPPA rs5068 and rs198358 was also associated with higher circulating natriuretic peptide levels (p=0.003 to p=0.04).
|
21276798 |
2011 |
|
rs5068
|
CLCN6;NPPA;NPPA-AS1
|
Hypertensive disease
|
|
0.030 |
GeneticVariation |
BEFREE |
Minor alleles of NPPA rs5068, rs5065 and rs198358 were associated with less history of hypertension; minor alleles of NPPA rs5068 and rs198358 was also associated with higher circulating natriuretic peptide levels (p=0.003 to p=0.04).
|
21276798 |
2011 |
|
rs5063
|
CLCN6;NPPA;NPPA-AS1
|
Atrial Fibrillation
|
|
0.030 |
GeneticVariation |
BEFREE |
Significant allelic association was detected between single nucleotide polymorphism (SNP) rs5063 and lone AF (p=0.015, OR=1.63; adjusted p=0.003).
|
20064500 |
2010 |
|
rs5063
|
CLCN6;NPPA;NPPA-AS1
|
Atrial Fibrillation
|
|
0.030 |
GeneticVariation |
BEFREE |
Recently, the rs5063 SNP has been reported to confer an increased risk of AF development in a Chinese population.
|
20543198 |
2010 |
|
rs5065
|
CLCN6;NPPA;NPPA-AS1
|
Hypertensive disease
|
|
0.030 |
GeneticVariation |
BEFREE |
Two common single nucleotide polymorphisms (SNPs) in NPPA, rs5063 and rs5065, result in amino acid changes of the primary peptide and have been previously implicated in conditions associated with AF, including stroke and hypertension.
|
20543198 |
2010 |